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Biomedical subjects

M Massetti

Publications and source records attributed to M Massetti.

65 records · Page 4Linked to original sources
PubMed1996

Operation for atrial septal defect through a right anterolateral thoracotomy: current outcome.

BACKGROUND: Operative closure of atrial septal defect is today considered a high-benefit and low-risk operation. Patients are often young and sensitive to the cosmetic results of the procedure. The midline scar of median sternotomy may be unsightly and can provoke dissatisfaction and psychological distress. For cosmetic reasons, an alternative operative approach, such as right anterolateral thoracotomy, can be proposed, with better aesthetic results and without increasing operative risks. METHODS: Our study reviews retrospectively the long-term results of a consecutive series of 56 young patients in whom the atrial septal defect was closed through a right submammary approach. The indication for this approach was isolated atrial septal defect in female patients with complete development of the breasts. RESULTS: In-hospital morbidity included three postpericardiotomy syndromes with one operative drainage for a moderate pericardial effusion (subxiphoid approach); 6 patients had supraventricular tachycardia in the early postoperative period. One patient presented with a symptomatic supraventricular arrhythmia and was treated medically for atrial flutter or fibrillation. Follow-up ranged from 12 to 240 months and included 41 of 57 patients. There were no early or late deaths. All patients were in normal sinus rhythm and free of symptoms, in New York Heart Association functional class I. Electrocardiography results showed 4 patients with first-degree atrioventricular block and 5 with complete right bundle branch block. Echocardiographic study results showed 3 patients with a trivial residual shunt. There were no other late complications. Breast volume and symmetry and the character of the scar were evaluated objectively by a physician and subjectively by a multiple-choice questionnaire completed by the same patients. The answers suggested that the patients' subjective impressions were at least commensurate with the objective findings. Most of the patients perceived the cosmetic results as good or excellent. No serious psychological problems related to the scar were found. CONCLUSIONS: Right thoracotomy incision is a safe alternative approach to median sternotomy to repair isolated atrial septal defect in young female patients.

Adolescent↗
PubMed1996

Transpericardial inferior vena caval cannulation in thoracic aorta operations.

Surgical treatment of thoracic aneurysms is frequently performed with the aid of partial cardiopulmonary bypass. When profound hypothermia and circulatory arrest are employed, inadequate venous drainage may represent a major problem. We herein describe a technique of inferior vena caval cannulation that allows steady performance when high pump flows are imposed.

Aorta, Thoracic↗
PubMed1996

[Cardiac transplantation. Evaluation of a consecutive series of 75 grafts].

OBJECTIVES: The global results of various series of heart transplantation (HT) are essential to assess the life expectancy provided by this technique. Due to the increasing graft shortage, it appears essential to very strictly candidates for HT. METHODS: From March 8, 1989 to December 7, 1994, 75 orthotopic Hts were performed in 62 men and 12 women (1 case of retransplantation). The mean age was 47.46 +/- 15.02 years (range: 2.5-66 years). Four patients were younger than 10 years and 22 were older than 60 years. Our series included more cases of ischaemic heart disease (36) than dilated cardiomyopathies (33), with a history of cardiac surgery in almost one quarter (20) of patients with ischaemic heart disease. RESULTS: The immediate postoperative survival rate was 94.7% with 3 deaths attributable to refractory pulmonary hypertension associated with graft failure and one death related to postoperative tamponade. Five other patients died during the following 3 months, increasing the mean global survival to 88%. After a mean follow-up of 2.1 years (maximum 5.8 years), the actuarial 5-year survival rate was 56.8%. Eleven patients died between 4 and 38 months (mean: 18.2 months). Two deaths were due to cancers, 4 were due to septicaemia, another 4 were due to rejection and finally 1 was due to meningeal haemorrhage. The frequency (19) of reoperations for clot removal was due to the large number of patients with a history of previous heart surgery (20). CONCLUSION: Strict recipient selection, possibly based on 123I-MIBG scintigraphy, the use of pulsatile circulatory assistance systems, improved CMV, morphometry and donor-recipient age matching, should optimize the results of a technique, whose efficacy is confirmed in this series.

Adolescent↗
PubMed1996

[Value of percutaneous carotid angioplasty before cardiac surgery].

Transluminal angioplasty (TLA) of asymptomatic carotid stenoses (> 85%) in patients candidates for coronary artery bypass graft for stable angina appears to be an interesting technique to evaluate in a population whose management is controversial. Between January 1993 and January 1995, 10 patients underwent Carotid TLA (CTLA) prior to coronary artery bypass grafts (mean: 17.4 days). The mean age was 71 +/- 4.3 years. Eight patients were classified as NYHA class II and two were classified as class III. The mean number of bypass grafts per patient was 2.7. Four patients presented contralateral thrombosis of the internal carotid artery. CTLA was performed under cerebral protection by means of a triple coaxial catheter. Six CTLA required a Strecker stent. The mean follow-up was 11.4 months, with no mortality. One patient presented with transient hemianopsia. All patients were reviewed at 4 months by follow-up angiography, followed by Doppler. Only one of the 10 patients reviewed required redilatation with complementary stenting and another patient required dilatation of the stent. Although the follow-up of this short series is brief, the results of CTLA are encouraging in this population with a high risk of morbidity and mortality (elderly patients, frequently bilateral carotid lesions, coronary bypass grafts with multiple arterial grafts.

Aged↗
PubMed1995

Aortopulmonary fistula: an uncommon complication in dystrophic aortic aneurysm.

Wall dissection is a typical complication in the evolution of Marfan aortic aneurysm and usually is associated with valve regurgitation. Formation of a fistula with adjacent structures is very uncommon. We report the case of a 32-year-old man who presented with the typical features of Marfan's syndrome, with chronic aneurysm of the ascending aorta and acute aortopulmonary fistula. Diagnosis was made preoperatively by aortography; operation was performed successfully. A review of the literature only shows a few cases of aortopulmonary fistula in atherosclerotic, syphilitic, or postendocarditis disease.

Acute Disease↗
PubMed1994

An animal model for the evaluation of graft thrombosis in the acute phase on carbon-lined PTFE prosthesis.

Forty-five carbon-lined (CL) and 45 standard (ST) 4 mm internal diameter polytetra-fluoroethylene (PTFE) grafts were implanted as aortic interposition in 90 rabbits. A pilot study of 20 animals: 10 CL and 10 ST grafts were used to develop microsurgical techniques, then 60 grafts were placed in 60 New Zealand rabbits with lower morbidity. The two hours graft patency (Doppler and angiographic studies) showed better patency rate in CL group (93% versus 80%). In 10 animals, platelet accumulation was investigated in vivo using gammacamera imaging after injection of autologous platelets labeled with Indium111. In vitro, radioactivity counting of the explanted midgraft sections at 2 hours revealed 6 times greater activity in ST grafts (6.60 +/- 1.98 x 10(3) platelets/mm2 versus 0.82 +/- 0.25 x 10(3) platelets/mm2; p < 0.05). Light microscopy found platelet and fibrin deposition (PFD) in nearly all ST grafts whereas PFD were found in only 13% of the CL grafts corresponding to those thrombosed (chi 2: 61.117, p < 0.001). Carbon-lining decreases platelet accumulation on PTFE grafts in the acute phase of a new experimental model.

Angiography↗
PubMed1993

[Value of the posterior route in the surgical treatment of popliteal aneurysm].

The authors report about 4 cases of surgical treatment of popliteal aneurysms through a strictly posterior approach. In all cases, the aneurysm was asymptomatic and diagnosed during the assessment of a controlateral symptomatic popliteal aneurysm that was treated in a conventional manner (exclusion and interposition of a femoropopliteal prosthetic tube through a medial approach). The procedure is carried out with the patient in ventral decubitus, and it consists in a debridement and graft with direct anatomical interposition of a straight PTFE tube. The posterior approach has limitations as it does not allow craniad extension and applies only to sacciform or short fusiform aneurysms the upper pole of which does not extend beyond Hunter's canal. The graft was an 8-mm PTFE straight tube in all 4 cases. All patients had a dynamic bilateral control angiography made and none of them presented with symptoms. Three conventional restorations required later embolectomy for thrombosis of the prosthesis. In our opinion, the use of the posterior approach for the surgery of popliteal aneurysm is appealing-provided strict criteria (aneurysm size, scheduled surgery, prosthesis) are complied with--as it reduces morbidity, restores the anatomical course and allows reducing the rate of postoperative thrombosis, thus ensuring better long-term patency.

Aneurysm↗
PubMedDate not supplied

Aortic balloon entrapment complicating intra-aortic balloon counterpulsation.

Short-term balloon counterpulsation may be complicated by aortic balloon entrapment. We report a patient in whom video-coronary surgery was performed using beating heart anastomosis. This patient developed intra-aortic balloon (IAB) entrapment 4 days after initiation of the counterpulsation previously implanted for a preoperative low ejection fraction. No limb ischaemia was detected, but urgent removal of the balloon catheter is mandatory if blood is detected in the tubing connecting the balloon to the console, even in the presence of adequate function of the IAB assistance.

Aged↗
PubMedDate not supplied

[Leiomyosarcoma of the heart and great vessels].

Leiomyosarcomas (LMS) of the heart are exceptional primary malignant tumours with a catastrophic prognosis and a mean survival measured in months. Extensive radical surgical resection clearly remains the most appropriate treatment. We report three cases observed over a 3-year period, consisting of an LMS of the inferior vena cava, an LMS of the pulmonary artery trunk and an LMS of the left atrium. The first case was treated by radical resection and reconstruction by autologous vein graft of the cavorenal junction, the second case was treated by extensive resection and prosthetic reconstruction of the pulmonary artery bifurcation and the third case was treated by a first radical resection of the left atrium, requiring total cardiectomy and orthotopic heart transplantation for local recurrence at the sixth month. The survical was significantly improved compared to other treatment options (chemotherapy, radiotherapy). The first patient is still alive without recurrence at two years; the second died 12.5 months after the surgical procedure and the medium-term follow-up of the transplanted patient revealed cerebral and hepatic metastases nine months after transplantation. The authors review the literature concerning these extremely rare malignant tumours. Recent progress of diagnostic investigations, such as spiral CT with reconstruction, MRI, positron emission tomography (PET), are now able to establish the diagnosis more rapidly and therefore allow more radical surgical resection. This resection, possibly combined with venous reconstruction, must be associated with adjuvant therapies. Heart transplantation should be considered among the treatment options for leiomyosarcomas of the heart, in order to improve the poor prognosis of these lesions affections a young population.

Brain Neoplasms↗