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Biomedical subjects

M Mathan

Publications and source records attributed to M Mathan.

7 recordsLinked to original sources
PubMed1978

Jejunal microbial flora of southern indian infants in health and with acute gastroenteritis.

The microbial flora of the jejunal lumen of 28 infants with acute gastroenteritis was compared with that of a group of 10 normal infants. The jejunum of control subjects harboured an "oral" type of flora and in a few instances enterobacteria in small numbers. The concentrations of all but one of the groups of organism were higher in the patients than in controls, and the differences were of statistical significance for enterobacteria and lactobacilli. In eight subjects, the same pathogen was identified in the jejunum and the stool. In six subjects with rotavirus infection, there were almost no Gram-negative aerobic rods in the jejunum. The possible role of other Gram-negative aerobic rods in producing gastroenteritis is discussed. It is suggested that studies of jejunal flora are of considerable importance in assigning an aetiological role to bacteria in the causation of acute gastroenteritis.

Acute Disease↗
PubMed1978

Villoglandular adenoma of the duodenum.

Two cases of villoglandular adenoma of the duodenum presenting with features of peptic ulcer are reported. At surgery both patients had intussusception of the duodenum. One of them had carcinoma in situ. The literature is briefly reviewed, and the importance of keeping in mind this rather rare condition, even in areas where duodenal ulcer is widely prevalent, is emphasized.

Adenoma↗
PubMed1977

An antigenic subunit present in rotavirus infected faeces.

It has been found by immune electron microscopy that rotavirus-infected faeces, calf or human, contain an antigenic subunit associated with the inner of the two virus capsids. This internal component represents the group specific antigen for the rotavirus group and the subunit reacts with both homologous and heterologous antiserum. It can therefore be used in diagnostic tests and in this paper its use as a reagent for immunodiffusion is described.

Animals↗
PubMed1977

Aetiology of acute gastroenteritis in infancy and early childhood in southern India.

The aetiology of acute gastroenteritis was studied in 50 infants and young children. Bacterial pathogens were isolated in 33, enteropathogenic E. coli (EPEC), Salmonella, and Shigella being the commonest isolates. Rotaviruses were detected in the stools of 13 of the cases. All children with gastroenteritis in whom rotavirus was detected were seen during the months July to December. In 30 children who served as controls, EPEC were isolated in 6, but rotavirus was detected in none. It is concluded that infection with rotaviruses is a significant cause of morbidity in children with gastroenteritis in southern India.

Acute Disease↗
PubMed1976

Morphogenesis of fetal rat duodenal villi.

To study the structural features of fetal rat duodenal mucosa associated with histogenesis of villi, duodena from 15- to 19-day fetuses were examined by light and electron microscopy. The duodenal epithelium of 15- to 18-day fetuses was stratified. Distinctive junctional complexes associated with membrane-bounded vesicles and cilia-like structures were seen in the deeper epithelial layers at 15 and 16 days. Small lumina, designated "secondary lumina," lined with a variable number of microvilli developed between epithelial cells at these junctional complexes during the sixteenth through eighteenth days. Degenerative changes and exfoliation of superficial epithelial cells were obvious in 17- and 18-day fetuses. In 18-day fetuses, aggregates of mesenchyme had invaginated the basal aspect of the stratified epithelium. Concomitantly, the number of epithelial layers overlying these mesenchymal projections was decreased. In 19-day fetuses, well formed, short duodenal villi lined by a simple columnar epithelium which included goblet and endocrine cells were evident. Injection of ferritin into the main duodenal lumen of 17-day fetuses failed to reveal continuity between the main lumen and the secondary lumina. However, continuity between many secondary lumina and the main lumen was demonstrated in 18-day fetuses. Thus, major morphological features associated with villus formation in fetal rat duodenum include: (1) formation of many secondary lumina in primitive stratified epithelium, (2) eventual fusion of these lumina with the main duodenal lumen, by their continued growth coupled with exfoliation of degenerating superficial layers and (3) upward growth of mesenchyme towards the lumen as cell exfoliation and expansion of secondary lumina take place.

Animals↗
PubMed1975

Pleomorphic virus-like particles in human faeces.

Pleomorphic fringed particles bearing some resemblance to orthomyxoviruses and coronaviruses were seen in 90 percent of stools from south Indian children and adults but not in stools from neonates. This finding may be related to the abnormalities of intestinal structure and function common in this region of India.

Adult↗