[Comparative study of the effect of cimetidine 800 mg once a day and 400 mg twice a day in the treatment of duodenal ulcer].
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Biomedical subjects
Publications and source records attributed to M Matos.
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We studied patients undergoing hemodialysis awaiting renal transplantation who had routine endoscopy as preoperative evaluation. Medical histories of 71 patients transplanted between 1982-1989 were reviewed retrospectively in order to determine the results of the upper gastrointestinal lesions. At the time of the endoscopy the predictive variables studied were: age, sex, BUN, creatinine, hemoglobin, hematocrit, calcium and time on hemodialysis. The patients were divided in two groups: those with lesions and a control group without lesions. The comparison between the two groups was done using unpaired t-test for continual variables, X2 for dichotomous variables and p < 0.05 was considered as statistically significant. Thirty two patients (45%) had lesions in the upper gastrointestinal tract, in the esophagus: 17%, stomach 30% and duodenum: 23%. Age was the only predictive variables statistically significant for gastric lesions. We conclude that gastrointestinal lesions are frequent in patients with end stage renal failure. The gastric lesions were the most frequent and appeared in older patients. We recommend endoscopic studies in all end stage renal failure patients as part of the pre transplant evaluation. We also suggest endoscopy as follow up after transplantation.
We present the humoral immunological findings in 18 patients with ulcerative colitis and two with Crohn's disease. All of them had the disease for 3 months to five years. Fifteen were hispanics and five from European origin. There were ten males and ten females, and an average age of 38 years. All patients had active disease from clinical and endoscopy points of view. Thirteen patients had abnormal values in one of the immunoglobulins and normal in seven patients. IgA was increased in eleven, normal in seven and decreased in two. IgG increased in two, decreased in one and normal in seventeen cases. IgM was found to be increased in five and normal in the rest. IgA secretory determination in saliva, was performed twelve patients and was positive in all of them. Antinuclear antibodies were negative in eight. Anti-smooth muscle were positive in three of fifteen. Anti-mitochondrial were present in one and negative in thirteen. Values of C3 and C4 were lower than normal in 3 and 2 cases respectively from 4 cases studied. CH50 was decreased in 2 of 11 cases studied. In the patients, no correlation was found between low complement values, the positivity of auto antibodies and the clinical parameters previously mentioned. We conclude that there is quantitative alterations of the humoral response and it is necessary the immunological study in persons with inflammatory bowel disease others studies are needed to establish the real value of these findings.
The range of magnification factors in 40'' and 72'' radiographs were calibrated using three simple mathods. The relationship between X-ray source to cassette distance, object to cassette distance and magnification factors was determined experimentally for both 40'' and 72'' radiographs. The resulting nomogram showed that: (1) there was no significant magnification difference between centered (AP-hip) and offset (AP-pelvis) radiographs; (2) magnification factors of 40'' films were twice those of 72'' films for the same object to cassette distances; and (3) due to the smaller magnification range of 72'' films (1 to 13%) compared to 40'' films (1 to 26%) there was less chance of error in determining magnification factors for the larger film distances. The skin radiation dosage for the patient was similar in both procedures. Magnification factors were also calculated from 414 A-P radiogrphs of total-hip prosthesis, using the femoral ball as a calibration standard. This provided magnifications of 20 per cent +/- 6(2SD) for 40'' films and by extrapolation on the nomogram gave corresponding values of 10 per cent +/- 3 for the 72'' films. The associated hip to cassette distances (L), also obtained from the nomogram, varied from 125 to 205 mm, average 165 mm. In subsequent clinical trials using 72'' films, it was possible to represent the patients as either small (L less than 145 mm) medium (145 less than or equal to L less than or equal to 185 mm) or large (L greater than 185 mm) with corresponding magnification factors of 8, 10 and 12 per cent, respectively. The error with this simplification was still within +/-21/2 per cent. For 40'' films the corresponding magnification factors for small, medium or large patient categories were 16, 20 and 24 per cent respectively with likely errors within +/-5 per cent. Magnification factors were also calculated from the radiographic image of a 100 mm long rod which had been attached to the patien's thigh. The overall accuracy with this method was comparable to the techniques described above and had the advantage that every radiograph featured its own scale, a particularly important feature for preoperative films which have no implant for calibration purposes. As a result of such simple calibration procedures, it was possible to identify the overall magnification variations and specify particular magnification factors within +/-21/2 per cent (72'' films) or +/-5 per cent (40'' films).