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Biomedical subjects

M Matsuki

Publications and source records attributed to M Matsuki.

At least 19 recordsLinked to original sources
PubMed1991

Effects of changes in angiotensin converting enzyme activity on renin release: pretreatment with dexamethasone enhances a plasma renin activity response to captopril in normal subjects.

Healthy adults were given captopril (25 mg and 75 mg) po with or without dexamethasone (DXM) pretreatment (1 mg po 2 h before and simultaneously with the captopril). We determined the serum potassium and sodium concentrations, plasma prostaglandin E2 level, PRA, serum angiotensin converting enzyme (ACE) activity, and aldosterone level from 20 min before to 120 min after administration of captopril. DXM pretreatment stimulated the PRA response to captopril. This stimulation was suppressed by indomethacin. However, the administration of DXM did not induce a consistent rise in the prostaglandin E2 level. The administration of DXM induced a significant rise in the potassium concentration, but since simultaneous administration of indomethacin with captopril induced the suppression of PRA without affecting the potassium level, the PRA increase in response to captopril with DXM was not caused directly by the potassium increase. There were no significant differences in the PRA increase between 25 mg captopril and 75 mg captopril, or between DXM-25 mg captopril and DXM-75 mg captopril, though the inhibitions of ACE activity by captopril differed according to dose. The PRA increases, but not the captopril-induced inhibition of ACE activity, were significantly different between captopril alone and captopril with DXM pretreatment at either dose of captopril. Thus, the inhibition of ACE activity perhaps allows PRA to increase in response to captopril. These results suggest that the DXM stimulation of PRA may have been dependent on the inhibition of ACE activity by captopril.

Adult↗
PubMed1991

Relationship between insertion torque and removal torque analyzed in fresh temporal bone.

Insertion torque and removal torque of fixtures were measured using human cadaver temporal bone and human living bone. The torque level for fracturing the threads of the bone was also measured. The maximum insertion torque exerted without causing a break in bone threads was 70.0 Ncm in bicortical bone and 50.0 Ncm in unicortical bone. The relationship between insertion torque and removal torque indicated a positive correlation between both sites. However, removal torque was lower than insertion torque in all measurements. The fracture points of bone threads were 77.0 Ncm in bicortical bone and 57.7 Ncm in unicortical bone by mean. Microfractures were observed mainly in the thread bases and were directed upward in the histologic specimens examined.

Aged↗
PubMed1990

[The effect of DREZ (dorsal root entry zone) lesions on intractable pain in patients with spinal cord injury].

Some patients with spinal cord injury complain of a severe intractable pain. This intractable pain places new hurdles on the road to return to the ordinary daily life in these patients. The effective therapy for the intractable pain has not been established. Dorsal root entry zone (DREZ) lesion was originally reported by Nashold et al to alleviate deafferented pain syndrome. Three male and one female patients with intractable pain following spinal cord injury were treated with DREZ-lesions. One month after operation, all 4 patients obtained good pain relief. However, at a follow-up period till February 1989 (ranging 11 months from 2 years and 6 months), 2 patients had subjective pain relief. When other therapies on intractable pain following spinal cord trauma are not effective, the DREZ-lesion might be considered.

Adult↗
PubMed1989

Column perifusion system for steroidogenesis in isolated rat adrenal cells.

A perifusion system using a plastic column into which isolated rat adrenal cells had been installed was attempted. After ACTH or cAMP was administered to the column, the corticosterone concentration in the eluate was determined. ACTH in 10(-13) and 10(-12) M did not promote corticosterone production, whereas 10(-11) and 10(-10) M showed a dose dependent production of corticosterone. By iterative infusion of 10(-11) or 10(-9) M of ACTH, very clear responses to restimulation of ACTH were noted. Following the administrations of 10(-3) or 10(-2) M of dibutyryl adenosine 3',5'-cyclic monophosphate (dbcAMP), the production of corticosterone increased dose-dependently. These results suggest that this perifusion system is effective for examining the effects of ACTH or cAMP on steroidogenesis of cells.

Adrenal Glands↗
PubMed1989

[Arthrographic investigation for the disk configuration with closed lock of the temporomandibular joint].

The authors examined arthrotomographies of 89 patients (96 joints) with closed lock of the temporomandibular joint to clarify the frequency of disk deformity correlated with disk perforation, bone change and patients' age. The disk configurations were divided into 3 types, those were type-1-elongated and preserved shape of the disk, 39 joints, type 2-folded disk, 11 joints, and type 3-massed disk, 46 joints. The frequency of disk deformity was 66.7% (64 joints). The numbers of disk perforation, (and bone change) in each type were type 1-2 (5) joints, type 2-1 (1) joint, and type 3-11 (13) joints. The average ages of each type were type 1-28.1 years, type-2-27.2 years, and type 3-40.1 years. These results indicate that high percentage of disk deformations exist in the closed lock patients with degenerative changes of the soft and hard parts of the temporomandibular joint.

Adult↗
PubMed1989

[Clinical study on mandibular condylar fracture. 2. Long-term follow-up study in 48 patients with 66 joints].

Sixty-six joints in 49 patients with mandibular condylar fracture were investigated by means of long-term follow-up observation. The group of patients consisted of 39 males and 10 females with ages from 15 to 75 years. The classification of the fractures was follows: MacLennan type 1; four, type 2; four, type 3; 39, and type 4; 39 joints respectively. Treatment was as follows: 25 joints were by conservative therapy, 31 joints were by surgical fixation, and 10 joints condylectomy. The follow-up period of observation ranged from 18 months to 10 years and one month an average of five years and seven months. Clinical assessment was based upon Nakatomi's dysfunction index on mandibular condylar fracture, of which the criteria are as follows; Excellent (No clinical dysfunction sign on the TMJ), Fair (Slight pain, noise, and limited range of motion of the mandible, but clinically no affected mastication), Poor (Moderate dysfunctioned jaw), and Failure (Severe dysfunctioned jaw). 23 joints in 18 patients were ranked as having excellent results. 31 joints in 22 patients were assessed as fair. Ten joints in seven patients were defined as poor, and the remaining two joints in two patients were failures. The overall success rate was 81.7%. There are no statistical differences between patient's groups based on age, sex, uni/bilateral modality, with/without other concomitant fracture, surgical/conservative procedure, location and form of fractures, and duration of period from injury. These results indicated that the conservative procedure would be the first choice as a reasonable and less invasive procedure for functional repair of mandibular condylar fracture. On the other hand, as most patients had some dysfunction sign on the TMJ after mandibular condylar fracture, a more appropriate treatment, surgical or otherwise, should be found.

Adolescent↗
PubMed1988

Effect of PSK, a protein-bound polysaccharide from Coriolus versicolor, on drug-metabolizing enzymes in sarcoma-180 bearing and normal mice.

The effects of PSK and Propionibacterium acnes (anaerobic Corynebacterium) on hepatic drug-metabolizing enzymes were studied using sarcoma-180 bearing and non-tumor bearing mice. PSK had no influence on aminopyrine N-demethylase and aniline hydroxylase activities, cytochrome P-450 concentration in hepatic microsomes, and the reductase activity of cytochrome c in normal mice. The content of cytochrome P-450 was not significantly reduced in S-180 bearing mice. On the other hand, P. acnes administration significantly decreased the amount of cytochromes P-450 and b5 and aminopyrine N-demethylase activity. When FT-207 (Tegafur) was administered orally to S-180 bearing mice combined with the immunoadjuvants, only P. acnes significantly reduced the 5-FU levels in the serum and some organs.

Adjuvants, Immunologic↗
PubMed1988

Provocation of a paradoxical growth hormone response to corticotropin-releasing hormone by pretreatment with metoclopramide in patients with acromegaly and normal subjects.

Two of 7 patients with acromegaly and one of 7 normal subjects exhibited a paradoxical rise in growth hormone (GH) to human corticotropin-releasing hormone (CRH) when pretreated with metoclopramide, although CRH alone did not induce an increase in GH. In one of these two patients with acromegaly, the GH increase to metoclopramide alone also reached the criteria of a paradoxical response. These two acromegalic patients showed a GH increase to metoclopramide pretreatment before and up to two months after surgery. In another acromegalic patient, whose GH level remained high 5 months after surgery, metoclopramide induced an increase in GH level, while in a patient who had an above-normal GH level 18 months after surgery, the resumption of physiological GH secretion after surgery was evidenced by a postoperative absence of a GH response to metoclopramide. It is suggested from these results that the GH response to metoclopramide and the metoclopramide-provoked GH response to CRH in patients with acromegaly result from the secretion of GH from nonadenomatous cells of the pituitary.

Acromegaly↗
PubMed1987

Pituitary-adrenocortical response to metoclopramide in patients with acromegaly and prolactinoma: a clinical evaluation of catecholamine-mediated adrenocorticotropin secretion.

We have demonstrated that metoclopramide stimulates cortisol secretion at least in part by a stress-mediated effect in normal men. To examine further the effect of the drug on the hypothalamo-pituitary adrenal system, we studied the cortisol response to 20 mg metoclopramide in patients with acromegaly, prolactinomas, and functional hyperprolactinemia and compared the results with the responses to insulin-induced hypoglycemia. In some patients, the effects of metoclopramide on CRH-induced ACTH and cortisol increase were studied to determine whether a change in dopaminergic (catecholaminergic) activity altered CRH stimulation of pituitary-adrenal function. No cortisol response to 20 mg metoclopramide occurred in 13 tests on 8 of 9 patients with prolactinoma or acromegaly with hyperprolactinemia, whereas both acromegalic patients without hyperprolactinemia had a response. All of the patients had a normal cortisol response to insulin-induced hypoglycemia. Pretreatment with metoclopramide enhanced the CRH-induced cortisol increase from 30-120 min after CRH in normal men, but only at 15 and 30 min in 5 agromegalic patients. The results suggest that metoclopramide acts in the hypothalamus to release ACTH through a dopamine antagonist-mediated (catecholaminergic) mechanism, and that metoclopramide may act additively with CRH to stimulate ACTH secretion in normal men. The absence of a metoclopramide-induced cortisol response in patients with acromegaly or prolactinomas and the absence of a normal cortisol response to metoclopramide-CRH in acromegalic patients could be due to endogenous catecholamine deficiency in these patients.

Acromegaly↗