PubMed Health⌕ Search

Biomedical subjects

M Matsumae

Publications and source records attributed to M Matsumae.

At least 19 recordsLinked to original sources
PubMed1998

Parasellar dermoid tumor with intra-tumoral hemorrhage.

We report a case of parasellar dermoid tumor with intra-tumoral hemorrhage. It is rare for a dermoid tumor that hemorrhage was detected as high attenuation on the initial CT. In the present case, the tumor content included a little fat component and mostly cholesterin-rich fluid which resulted in extremely low signal intensity on T2-weighted and high signal on T1-weighted MR images. In addition to this, hemosiderin accumulation in the tumor could be the reason for low signal intensity on T2-weighted images.

Adipose Tissue↗
PubMed1998

Pericellular deposition of basement membrane material in myxoid meningioma: immunohistochemical evidence for unbalanced production of type IV collagen and laminin.

Myxoid meningioma seen in a 25-year-old man is presented. Histologically, Leu 7-positive meningotheliomatous tumor cells were embedded in the alcianophilic myxoid matrix. Characteristically, eosinophilic granular deposition was detected around the tumor cells and the boundary of tumor cells was not clearly defined. The pericellular deposits revealed the nature of the basement membrane with positive reactions by periodic acid-Schiff (PAS) sequence and immunostaining for type IV collagen, which is the major structural component of basement membrane. However, laminin, which is a non-collagenous glycoprotein of the basement membrane, was undetectable, and silver was not impregnated. Similar abnormal deposition of PAS-positive basement membrane-like material was observed in the myxoid stroma of a microcystic meningioma among 72 meningiomas additionally examined. The significance of the discrepant localization of immunoreactive type IV collagen and laminin is discussed.

Adult↗
PubMed1998

Magnetic resonance cisternography for visualization of intracisternal fine structures.

OBJECT: To assess its usefulness in demonstrating cisternal anatomy, the authors investigated magnetic resonance (MR) cisternography in which a heavily T2-weighted turbo spin-echo method was used to visualize normal anatomical fine structures and lesions in the basal cisterns in 20 healthy volunteers and 43 patients. The authors applied peripheral pulse gating, which had been optimized to reduce artifacts in the cisterns attributable to cerebrospinal fluid (CSF) flow. METHODS: The detectability of each cranial nerve was determined in healthy volunteers. The first, second, and third nerves and the seventh-eighth nerve complex were clearly visualized in all participants; the fifth nerve was clearly seen in 80% and the sixth cranial nerve in 50%. The fourth nerve and the ninth through 12th nerves were difficult to identify individually, except in some volunteers. To reduce artifacts caused by fast CSF flow, we determined the delays as a function of the time elapsed between two consecutive peaks of pulse wave in a peripheral pulse gate (P-P interval) at which there was reversal of flow direction to minimize the CSF flow-related artifact. Using peripheral pulse gating and a time delay of 30% of the R-R interval, the authors succeeded in minimizing the CSF flow-related artifacts. Magnetic resonance cisternography appears to be very useful for demonstrating intracisternal fine anatomy and enhancing the contours of the juxtacisternal lesion. A minute amount of CSF interposed between lesions and normal structures such as nerves, vessels, or bone structures can be detected by means of this sequence. In patients with facial spasm, axial images and oblique coronal images obtained in a plane parallel to the seventh-eighth cranial nerve complex demonstrated vascular compression in all 13 patients. The MR cisternography finding of compression was confirmed in all nine patients who underwent microvascular decompression. CONCLUSIONS: Magnetic resonance cisternography appears to show great promise for evaluation of patients with neurovascular compression or tumors in and around the basal cisterns; the procedure adds only a small amount of imaging time.

Adult↗
PubMed1998

[Delayed ischemic neurological deficit that developed over 15 days after subarachnoid hemorrhage].

We retrospectively studied subarachnoid hemorrhage (SAH) patients with delayed ischemic neurological deficit (DIND), and analyzed the factors causing extremely late onset of deficits occurring over 15 days after onset of the SAH. Among 605 patients with SAH, 201 (33%) developed DIND. Among DIND patients, 137 had undergone early aneurysm surgery. In these 137 patients, onset date of DIND was definite in 131 patients. Six patients (5%) developed DIND over 15 days after SAH. All 6 had asymptomatic angiographical vasospasm and infections, most often meningitis, before the onset of DIND. Compared with cases in which there was ordinary onset of DIND, other statistically significant factors among these 6 patients were intracerebral hemorrhage, sepsis and meningitis. We suspect that DIND were manifested subclinically in the early period because of the associated hyperdynamic hemodynamics resulting from sepsis in these patients.

Adult↗
PubMed1997

Glucose metabolism and protective biochemical mechanisms in a rat brain affected by kaolin-induced hydrocephalus.

To clarify glucose metabolism in a hydrocephalic rat brain, substances related to glycolytic metabolism were biochemically measured. Kaolin-induced hydrocephalic rats were sacrificed and lactate dehydrogenase (LDH), LDH isozyme, lactate, adenosine triphosphate (ATP), and isocitrate dehydrogenase (ICDH) were measured in the following regions: cortex, thalamus, midbrain, hippocampus, cerebellum, and pons with medulla. During the development of hydrocephalus, lactate and LDH increased in most regions, the LDH M-subunit increased in the cortex, and ICDH decreased in most regions. However, ATP levels did not change. The increases in lactate, LDH and M-subunit suggested an anaerobic environment in the cell leading to activation of the anaerobic glycolysis. The decrease in ICDH represented a diminution of the tricarboxylic acid cycle. Through these alterations, the ATP level can be kept constant during the course of hydrocephalus, allowing the brain to create a better biochemical milieu.

Adenosine Triphosphate↗
PubMed1997

A diabetic case with hemoglobin J-Meerut and low HbA1C levels.

A diabetic patient with hemoglobin (Hb) J-Meerut and low HbA1C levels is reported. An automatic glycohemoglobin analyzer used for the determination of HbA1C revealed an abnormal peak of the peripheral blood obtained from a Japanese female with diabetes. She showed a lower HbA1C level (3.7%) than expected from her fasting plasma glucose (172 mg/dl). High performance liquid chromatography and isoelectric focusing indicated that her abnormal hemoglobin was Hb J-Meerut [alpha 120(H3)Ala-->Glu] and it accounted for 28.3% of the total hemoglobin. Abnormal hemoglobinemia should be considered when a major discrepancy between the levels of HbA1C and fasting plasma glucose is observed.

Blood Glucose↗
PubMed1996

Neurovascular developmental interaction: a specific form of vascular maldevelopment in the malformed brain. I. An experimental study and proposal of a new teratological concept.

The process of the development of the intracranial vessels was studied by means of immunohistochemical analysis of factor VIII in normal and exencephalic chick fetuses. The results revealed that the development of blood vessels in exencephalic brain was far advanced beyond the norm, with intense immunoreactivity to factor VIII on postincubation day 16 exceeding that on day 21 in normal controls. Compared with results regarding the direction of the overgrowth in the neuronal maturation process in the previous study using the chick exencephaly model, the findings of overmatured blood vessels were compatible with NSE- and somatostatin-positive elements that appeared especially in the overgrowth foci. The results of the present study suggested the pathogenic development of the "area cerebrovasculosa" in the neural placode as a phenomenon consequent upon hypervascularization in response to neuronal overgrowth, as seen in human cases of exencephaly or anencephaly. We emphasize the significance of this specific phenomenon in the development of the fetal central nervous system, namely neurovascular developmental interaction.

Animals↗
PubMed1996

Intracranial compartment volumes in patients with enlarged ventricles assessed by magnetic resonance-based image processing.

Magnetic resonance image-based computerized segmentation was used to measure the volumes of the brain, gray and white matter components, and to identify regions with prolonged enhancement on T2-weighted imaging, such as periventricular or deep white matter hyperintensities. The authors also determined the volumes of the ventricles and subarachnoid space in control subjects and in patients with: 1) aqueductal stenosis (AS); 2) other causes of obstructive hydrocephalus (OH); 3) Alzheimer's disease (AD); and 4) normal-pressure hydrocephalus (NPH). In AS the volume of the brain was smaller, whereas that of ventricles and subarachnoid cerebrospinal fluid space was larger than that of controls. The decrease in brain volume was due primarily to white matter loss. Although in OH the ventricles were larger, the subarachnoid space was smaller than in controls, presumably due to encroachment by the brain, in which the volume remained unchanged. In AD, loss of both gray and white matter resulted in a smaller brain volume, whereas that of ventricles and subarachnoid space was larger than in controls. In NPH patients, only ventricular volume was greater, whereas all other compartments were similar to controls. The brain normally occupies 87% to 92% of the intracranial volume and consequently, as observed in our patients, relatively small decrements in brain size lead to large increments in ventricular and/or extraventricular volumes. The magnitude of such changes differed markedly among our patient groups, and whether such changes prove useful in clinical assessment and differentiation needs to be determined.

Adult↗
PubMed1996

Age-related changes in intracranial compartment volumes in normal adults assessed by magnetic resonance imaging.

Magnetic resonance (MR) image-based computerized segmentation was used to measure various intracranial compartments in 49 normal volunteers ranging in age from 24 to 80 years to determine age-related changes in brain, ventricular, and extraventricular cerebrospinal fluid (CSF) volumes. The total intracranial volume (sum of brain, ventricular, and extraventricular CSF) averaged 1469 +/- 102 cm3 in men and 1289 +/- 111 cm3 in women. The difference was attributable primarily to brain volume, which accounted for 88.6% of the respective intracranial volumes in both sexes, but was significantly larger in men (1302 +/- 112 cm3) than in women (1143 +/- 105 cm3). In both, the cranial CSF volume averaged 11.4%. Total intracranial volume did not change with age, although the normalized brain volume of both men and women began to decrease after the age of 40 years. This decrease was best reflected by expansion of the extraventricular CSF volume which, after the age of 50 years, was more marked in men than in women. The volume of the cranial CSF, as determined by MR image-based computerized segmentation, is considerably larger than traditionally accepted and resides mostly extraventricularly. Expansion of CSF volume with age provides a good index of brain shrinkage although evolving changes and growth of the head with age tend to confound the results.

Adult↗
PubMed1996

Computer-assisted interactive three-dimensional planning for neurosurgical procedures.

We have used three-dimensional reconstruction magnetic resonance imaging techniques to understand the anatomic complexity of operative brain lesions and to improve preoperative surgical planning. We report our experience with 14 cases, including intra- and extra-axial tumors and a vascular malformation. In each case, preoperative planning was performed using magnetic resonance imaging-based three-dimensional renderings of surgically critical structures, such as eloquent cortices, gray matter nuclei, white matter tracts, and blood vessels. Simulations, using the interactive manipulation of three-dimensional data, provided an efficient and comprehensive way to appreciate the anatomic relationships. Interactive three-dimensional computer-assisted preoperative simulations provided otherwise inaccessible information that was useful for the surgical removal of brain lesions.

Adolescent↗
PubMed1995

Neuronal overmaturation in dysraphism: ontogenic expression of neuropeptides in the fetal brain and developmental anomalies in exencephaly.

Starting from knowledge obtained in our previous studies of experimental dysraphism in chick embryos, the entity of neuronal overgrowth observed in exencephaly was further investigated. The ontogenic expression of neuron-specific enolase (NSE), vasoactive intestinal polypeptide (VIP), and somatostatin was analyzed both in chick exencephaly of the natural product and in normal chick fetuses by carrying out immunohistochemical studies. In normal fetuses, immunostained elements positive for NSE first appeared in the spinal gray matter on postincubation day 16 and increased in intensity during the fetal period. By postnatal day 2, the cerebral peduncle, brain stem neurofibers, molecular layer of the cerebellum, corpus striatum, and piriform cortex became immunoreactive. No immunohistochemical reaction to VIP was observed during these stages. Somatostatin-positive elements were not identified during the fetal period, except in limited regions, such as the corpus striatum, which appeared to have weakly positive staining on day 21. The exencephalic fetuses, however, demonstrated extremely advanced neuronal maturation, with intense immunoreactivity already being manifest in various regions, including the corpus striatum, piriform cortex, spinal gray matter, and brain stem nuclei, on day 16 of the fetal period. Somatostatin-positive elements also appeared at this stage in chick exencephaly, but such immunoreactivity was localized, particularly in the overgrown foci. The present study showed that the neuronal maturation process in some neurons of exencephalic brain and spinal cord was definitely further advanced than that in normal controls. A possible clinical application of NSE and somatostatin measurement as markers for dysraphic states in the fetus is suggested.

Amniotic Fluid↗
PubMed1993

The neurobiology of normal pressure hydrocephalus.

Normal pressure hydrocephalus (NPH) is an intriguing problem in cerebrospinal fluid (CSF) and brain parenchymal physiology. This article presents what is known about its pathophysiology as well as its clinical presentation and treatment.

Humans↗
PubMed1991

Laser-assisted fibrinogen bonding of vascular tissue.

Characterization of the stress-strain profiles of welded tissue would provide an additional means of analyzing this new technology and comparing it with alternative anastomosing techniques. Rabbit longitudinal aortotomies were repaired with either 7-O polypropylene sutures or an 808-nm diode laser (power density, 4.8 watts/cm2) after topical application of fibrinogen mixed with indocyanine green dye (peak absorption, 805 nm). The rabbits were sacrificed between 0 and 28 days, and the fresh aortic specimens were strained axially in diluted plasma solution until ultimate breakage occurred in order to produce a stress-strain profile graph. No significant differences were noted between sutured and bonded aorta at any time interval. Nonincised aortic tissue (378 lb/in2) withstood significantly higher stress (P less than 0.05) than both sutured (257 lb/in2) and bonded (210 lb/in2) groups at the time of creation. By 7 days after operation, however, no significant differences were noted among any of the three groups. At 28 days after operation, the laser-bonded aorta was significantly stronger than the control aorta (P less than 0.05). The only significant difference in modulus (stretchability) identified the sutured aorta (373 lb/in2) to be more rigid than the control aorta (231 lb/in2) (P less than 0.05). Both sutured and laser-bonded anastomoses are weaker than control aorta initially; however, after an early critical period, both treatments achieve the strength of control aorta. By 1 month postoperatively, sutured anastomoses have the disadvantage of being less distensible.

Animals↗
PubMed1990

Energy metabolism in kaolin-induced hydrocephalic rat brain. Assessed by phosphorus (31P) magnetic resonance spectroscopy and the diversity of lactate-dehydrogenase and its isoenzyme patterns.

Energy metabolism in kaolin-induced hydrocephalic rat brain was assessed by means of 31-phosphorus magnetic resonance spectroscopy and measurement of the activity of lactate dehydrogenase (LDH) as well as its isoenzyme patterns. Decreases in beta-adenosine triphosphate and phosphocreatine were observed in hydrocephalic rat brains. While the intracellular pH was decreased at 2 to 4 weeks, it showed some recovery 6 weeks after injection of kaolin. The activity of LDH increased in the hydrocephalic state, and its isoenzyme-pattern changes were as follows: the LDH5 fraction was predominant in 1-week to 4-week rats while the LDH4 fraction was predominant in 4-week rat brains, and at 6-weeks, the LDH4 and LDH5 fractions were decreased. These data from rat brains with kaolin-induced hydrocephalus indicate that anaerobic glycolysis is the primary pathway of energy metabolism in the acute hydrocephalic state, while in the chronic state the emphasis shifts to aerobic glycolysis.

Animals↗
PubMed1990

A flexible sutureless intraluminal graft that becomes rigid after placement in the aorta.

A new sutureless intraluminal graft has been developed with a ring made of a coiled, overlapping, stainless steel spring with ratchets in one overlapping end. This graft is flexible during insertion but becomes rigid after proper intraaortic placement as the spool is dilated and the ratchest lock into position. The new graft was implanted in 10 dogs and was evaluated histologically and angiographically at various intervals. No ring dislodgment, aortic rupture, stenosis, or aneurysmal dilation was observed. The flexible component of this graft allows it to be introduced and secured in place easily and provides a technical advantage compared with the clinically used rigid intraluminal graft.

Animals↗
PubMed1990

[A case report: persistent primitive hypoglossal artery aneurysm].

The authors describe a case of persistent primitive hypoglossal artery aneurysm in a 42-year-old woman who had complained of headache, mainly in the occiput, for 5 days prior to admission. Because of a sudden exacerbation of the headache associated with vomiting, she was hospitalized on July 31, 1988. On admission, a cranial computed tomography scan demonstrated a high density lesion in the basal cisterns which suggested subarachnoid hemorrhage (SAH). Right carotid angiography revealed a persistent primitive hypoglossal artery and an aneurysm arising from this artery at the junction of the posterior inferior cerebellar artery. Bilateral vertebral arteries were shown to be hypoplastic. This was followed by a right suboccipital craniectomy on the 6th hospital day at which time a neck clipping was made. Her postoperative course was uneventful. On discharge on August 22, she was ambulatory and had no neurological deficit except for a mild hoarseness which developed after surgery. Well over one hundred cases of persistent primitive hypoglossal artery aneurysm have been reported. However, as far as we could discern, there have been only 9 cases of persistent primitive hypoglossal artery aneurysm including this present case. Most of the cases had SAH due to the rupture of these aneurysms with favorable outcome after the surgery. In addition, some embryological considerations were made.

Adult↗
PubMed1989

Quantification of cerebrospinal fluid shunt flow rates. Assessment of the programmable pressure valve.

Shunt placement diverting cerebrospinal fluid (CSF) has been the treatment of choice for hydrocephalus for the past several decades. However, the procedure often requires revisions owing to excessive drainage, low CSF flow rates, or infections within the system. With regard to valve pressure, selection of an appropriate valve for a specific patient prior to surgery is not always a simple task. Further, an optimal valve selected at the time of implantation may no longer be appropriate given changing pathophysiological conditions as time passes. It is thus desirable to provide a single valve in which the pressure may be modified when necessary without revision. A programmable pressure valve (designed by Sophysa of France) comes in one model which accommodates different pressure settings obviating revision when pressure changes are needed. Pressure changes can be achieved externally by means of a special magnet which allows precise adjustments in valve pressure to be made through the scalp. The authors introduce the mechanism and describe the cases treated using this valve.

Adult↗