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Biomedical subjects

M Matthies

Publications and source records attributed to M Matthies.

25 records · Page 2Linked to original sources

Phonemic resetting versus postural adjustments in the speech of cochlear implant users: an exploration of voice-onset time.

Voice-onset time (VOT) was measured in plosive-initial syllables uttered by five cochlear implant users prior to and repeatedly at intervals after activation of their speech processors. In "short-term" experiments, the elicitation set was read after the subject's processor has been off for 24 h, then turned on them off again. Four out of five implant users increased voiceless and/or voiced VOTc (VOT corrected for changes in syllable duration) from preimplant baselines to final recordings made 1-3 years later. Measured acoustic correlates of speech "posture" (average SPL, F0, and low-frequency spectral slope) changed concurrently. Results in the short-term study were largely consistent with the long term. Significant multiple regressions relating changes in VOTc to accompanying changes in postural correlates were found in both studies. This outcome is consistent with hypotheses that predict changes in both VOTc and in postural correlates with the restoration of some hearing and that allow for linkages between the two. Some of the reliable VOTc increases obtained over the long term that were not correlated with postural changes may have been caused directly by auditory validation of articulatory/acoustic relations that underlie synergisms for phoneme production.

Cochlea↗

The relevance of aquatic organisms' lipid content to the toxicity of lipophilic chemicals: toxicity of lindane to different fish species.

The acute toxicity (48-hr LC50) of lindane (gamma-HCH) to 16 fish species, belonging to eight families, ranges from 22 to 900 micrograms/liter (mean: 150 micrograms/liter). A significant positive linear relationship between the lipid content (% on a wet weight basis) of the fishes and their toxicity to gamma-HCH was found. If the toxicity is referred to 1% lipid, 48-hr LC50 values range between 13.2 and 32 micrograms/liter, and thus the coefficient of variation of the mean is reduced from 139 to 22%. It is concluded that the lipids of aquatic organisms serve as a protective reservoir against the toxic effects of lindane and other lipophilic, relatively persistent organic chemicals, because they are bioconcentrated mainly in the body lipids. Therefore, in organisms with high lipid content, only a relatively small fraction of the hydrophobic chemical can reach target organs (nerves, liver, etc.) and/or receptors. For comparing toxicity data of organic chemicals to aquatic organisms, the total lipid content of the organisms must be considered. The results of this investigation are important in comparative environmental toxicology for risk assessment of freshwater and marine organisms.

Animals↗

Possible future trends of radiation exposure by carbon 14.

The possible future trends of the radiation exposure by carbon 14 have been assessed. The individual lifetime doses and the European and global dose commitments were calculated by a specific activity model. A non-linear compartment model was developed so simulate the global cycling of carbon dioxide from the combustion of fossil fuels and of radiocarbon released from nuclear energy facilities until the year 2200. The energy scenarios considered are: (I) logistic growth functions for energy supply with fossil fuels; (II) a high, low and moderate estimate for the extension of nuclear energy (light water reactors). In addition, the influence of the retention of C-14 in the fuel reprocessing plant effluents was tested. For most of the scenarios considered the increase of the specific activity by C-14 releases is more than compensated by the CO2 releases from fossil fuels. Up to 2200 individual lifetime dose commitments for 70 years were found between 0.85 and 0.45 mSv (pre-industrial value: 0.73 mSv). The anthropogenic contributions to the global collective dose commitments until the year 2100 were estimated (for the moderate scenario without retention) at 1.27 X 10(6) man-Sv (11%) from nuclear weapon tests, 3.5 X 10(5) man-Sv (3%) from nuclear power plants, and 6.5 X 10(5) man-Sv (5.6%) from fuel reprocessing facilities.

Carbon Radioisotopes↗