Pharmacokinetics of factor VIII:C. Appropriateness of the one-compartment model for estimating clearance.
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Antigens↗
Biomedical subjects
M Matucci
Publications and source records attributed to M Matucci.
[Ectopic thymic cysts of the anterior mediastinum].
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Female↗
Cryoprecipitate and Factor VIII commercial concentrates: in vitro characteristics and in vivo compartmental analysis.
In vitro and in vivo characteristics of cryoprecipitates and three commercial factor VIII concentrates (Kryobulin, Hemofil and Koate) were comparatively studied. Factor VIII:C/VIIIR:Ag ratio was very low in all commercial concentrates without differences among them. Conversely, the decrease of factor VIIIR:WFRCof was proportional to the degree of purity. Factor VIII:C/VIIIR:WFRCof ratio was shown to be a reliable index of factor VIII complex denaturation. Crossed electroimmunoassay showed a faster migration of factor VIIIR:Ag only in commercial concentrates. Using a two-compartmental open model that accounts for endogenous synthesis of factor VIII:C, single-dose kinetics of factor VIII:C were studied in 23 patients with classic hemophilia. Good agreement between measured and fitted values of factor VIII:C plasma concentration was observed. beta half-life was shorter in high purity concentrates and longer in intermediate purity concentrates and cryoprecipitates.
Antigens↗
Comparison of two pharmacokinetic techniques for individualizing factor VIII dosage in haemophilia patients.
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Dose-Response Relationship, Drug↗