Biomedical subjects

M Mazik

Publications and source records attributed to M Mazik.

3 recordsLinked to original sources

PubMed2001

Molecular recognition of carbohydrates by artificial receptors: systematic studies towards recognition motifs for carbohydrates.

The synthesis and binding properties for carbohydrates of several artificial, acyclic receptors containing two or three heterocyclic recognition units covalently attached to a phenyl spacer is described. These host molecules having uncharged hydrogen-bonding sites were used in a systematic study towards the evaluation of recognition motifs for carbohydrates. A novel effective, acyclic hydrogen-bonding receptor possessing naphthyridine-amide moieties as heterocyclic recognition units has been developed.

Journal Article↗

PubMed2000

Programmed construction of discrete self-assembled cyclic aggregates

Examples for programmed self-assembly of alpha,beta-unsaturated ketoximes carrying a terminal pyridine subunit are described. The solid-state structures of a series of pyridinyl alpha,beta-unsaturated ketoximes 1 were investigated by X-ray structural analysis; this demonstrated that molecules 3-5 predictably form discrete cyclic aggregates stabilized by a network of hydrogen bonds and aromatic interactions.

Journal Article↗

PubMed2000

Molecular Recognition of Carbohydrates by Artificial Polypyridine and Polypyrimidine Receptors.

Despite their acyclic structure, the simple host molecules 1 and 2 can effectively hydrogen bond to monosaccharides. They show marked binding affinities to glucopyranosides in chloroform, and they are able to participate in three-dimensional recognition of monosaccharides.

Journal Article↗