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Biomedical subjects

M McWilliams

Publications and source records attributed to M McWilliams.

At least 19 recordsLinked to original sources
PubMed2000

Hot and dry deep crustal xenoliths from tibet

Anhydrous metasedimentary and mafic xenoliths entrained in 3-million-year-old shoshonitic lavas of the central Tibetan Plateau record a thermal gradient reaching about 800 degrees to 1000 degrees C at a depth of 30 to 50 kilometers; just before extraction, these same xenoliths were heated as much as 200 degrees C. Although these rocks show that the central Tibetan crust is hot enough to cause even dehydration melting of mica, the absence of hydrous minerals, and the match of our calculated P-wave speeds and Poisson's ratios with seismological observations, argue against the presence of widespread crustal melting.

Journal Article↗
PubMed2000

Tephrochronologic Constraints on Temporal Distribution of Large Landslides in Northwest Argentina.

Two morphologic settings in the northwestern Argentine prone to giant mountain-front collapse-deeply incised narrow valleys and steep range fronts bordering broad piedmonts-were analyzed through detailed investigations of fossil landslides and related fluvio-lacustrine sediments. Nine different rhyodactic tephra layers were defined by geochemical fingerprinting of glass, morphology of pumice, stratigraphic relationships, and mineralogy. The age of three tephra could be determined either directly by 40Ar/39Ar dating or relatively by 14C dating of associated sediments: Paranilla Ash (723+/-89 ka), Quebrada del Tonco Ash ( approximately 30 ka), and Alemanía Ash ( approximately 3.7 ka). These units permit correlation of several spatially separate landslide deposits. Landslide deposits in narrow valleys were generated in the late Pleistocene between 40 and 25 ka and in the Holocene since ca. 5 ka and correspond to periods characterized by increased humidity in subtropical South America. In contrast, the age of large landslides in piedmont regions is significantly greater but more difficult to define by tephrochronology. However, selected deposits from this second environment have cosmogenic nuclide exposure ages of 140-400 ka. Because of the large distance of the collapsed mountain fronts from eroding streams and because of important Quaternary displacement along the mountain-bounding faults, we suggest that strong, low-frequency seismic activity is the most likely trigger mechanism for most of the landslides in this environment.

Journal Article↗
PubMed1999

Markers for domestic violence in women.

OBJECTIVE: To determine injury patterns and characteristics specific to domestic violence in women who present to the accident and emergency (A&E) department. DESIGN: A retrospective case note review of all female assaults over a one year period. The subjects were women who disclosed that their injuries were due to assaults by either a current or a previous male partner. Controls were female assault victims not injured by domestic violence. SETTING: A medium sized urban A&E department. RESULTS: There were 500 female assaults out of 48,169 new attendances. Domestic violence was disclosed in 103 cases. The following features were significantly associated with domestic violence in women: multiple injuries (p < 0.001) (especially to the head and arms), fractures (p < 0.05), loss of consciousness (p < 0.05), abdominal injuries (p < 0.05), pregnancy (p = 0.01), injury occurring on "stairs" (p = 0.01), and general practitioner referral (p < 0.01). CONCLUSIONS: Women who have been assaulted are more likely to have been injured during domestic violence if they sustain multiple injuries (including fractures), abdominal injuries, have lost consciousness, or have been referred by their general practitioner. These markers may help medical staff to identify more cases of undisclosed domestic violence. The markers need to be tested further in a prospective study.

Adolescent↗
PubMed1999

Care of the pregnant patient in the dental office.

Attention to a woman's dental health can and should continue throughout pregnancy. The treating dentist must be diligent to the special situations surrounding treating the pregnant patient and the risks involved for both fetus and mother. Undertaking the proper precautions with these patients not only provides the best dental care, but also helps avoid potential complications. Any complication or question that arises with a complicated pregnancy should prompt referral to the patient's obstetrician for further evaluation.

Abnormalities, Drug-Induced↗
PubMed1996

An Archean Geomagnetic Reversal in the Kaap Valley Pluton, South Africa

The Kaap Valley pluton in South Africa is a tonalite intrusion associated with the Archean Barberton Greenstone Belt. Antipodal paleomagnetic directions determined from the central and marginal parts of the pluton record a geomagnetic reversal that occurred as the pluton cooled. The age of the reversal is constrained by an 40Ar/39Ar plateau age from hornblende at 3214 +/- 4 million years, making it the oldest known reversal. The data presented here suggest that Earth has had a reversing, perhaps dipolar, magnetic field since at least 3.2 billion years ago.

Journal Article↗
PubMed1979

Organ and isotype distribution of plasma cells producing specific antibody after oral immunization: evidence for a generalized secretory immune system.

Mice were induced to produce IgA antibodies against ferritin after oral immunization. Such antibodies were detected by immunofluorescence in plasma cells in the intestinal mucosa as well as in secretory sites located elsewhere, such as the lactating mammary gland, salivary gland, and respiratory tract. The observation suggested that cells immunized locally via the gut could home to distant secretory sites. To confirm this hypothesis, lymphocyte transfer studies were done with mesenteric node (MN) versus peripheral node (PN) cells from orally immunized donors into nonimmunized recipients. IgA anti-ferritin cells from MN homed to exocrine targets, whereas IgM and IgG anti-ferritin cells homed to PN. The findings overall support the concept of a generalized and interrelated secretory immune system.

Animals↗
PubMed1979

Caffeine content of common beverages.

Tea, coffee, carbonated and chocolate beverages were analyzed for caffeine, and results compared in terms of usual serving sizes. Significant differences in caffeine levels were found to result from the preparation method of coffee or brewing time of tea. It is possible for a cup of tea, instant coffee, or can of cola beverage to have similar caffeine content (55 to 65 mg.); however, the mean values per cup of black tea (28 to 46 mg.) are considerably lower than for brewed coffee (107 to 151 mg.). Caffeine is readily absorbed and can have pharmacologic effects on adults or on children who consume quantities of cola beverages or chocolate. Both preparation method and quantity of beverage consumed should be considered in taking dietary histories or estimating caffeine intake.

Beverages↗
PubMed1978

Development of the IgA system in the mammary gland.

1) Lymphoblasts in gut-associated lymphoid tissue, committed to the production of IgA, can home to the mammary glands of syngeneic mice and differentiate there into IgA-containing plasmablasts. The phenomenon is limited to near term and lactating recipients. 2) The ability of lymphocytes originating in gut-associated lymphoid tissue and sensitized to intestinal antigens to migrate to the mammary gland can account for the specificity of milk IgA toward intestinal microorganisms and the consequent passive protection offered to suckling infants. 3) The secretory immune system of the mammary gland is apparently under hormonal control since mammotropic hormones given to virgin females can induce morphological and functional characteristics seen naturally only during pregnancy and lactation. Examples are increased numbers of IgA plasma cells and the ability to trap their circulating precursors taken from mesenteric lymph nodes.

Animals↗
PubMed1978

Hormonal induction of the secretory immune system in the mammary gland.

The secretory immune system of the mammary gland is undeveloped in virgin mice but becomes active at term and during lactation. This change appears to depend on migration to the mammary gland of precursors of IgA-secreting cells derived from the gut-associated lymphoid tissue, an origin which explains the specificity of milk IgA antibodies for enteric organisms. Because development of the epithelial components of the mammary gland is clearly under hormonal control, we examined the effect of mammotropic hormones on differentiation of the immune elements. Under a combined regimen of progesterone, estrogen, and prolactin, development of the glandular epithelium occurs with concomitant increments in the number of IgA-secreting plasma cells and amount of intraepithelial IgA. These increases appear to be due to enhanced capacity of the gland to attract or retain precursors of IgA plasma cells derived from gut-associated lymphoid tissue. Testosterone, which antagonizes lactation, also antagonizes development of the secretory immune system and decreases cellular trapping in the lactating gland. The ability of the gland to trap IgA immunoblasts is probably contingent upon a hormone-induced increase in receptors.

Animals↗
PubMed1977

Origin of IgA-secreting plasma cells in the mammary gland.

Lymphoblasts from the mesenteric lymph nodes (MN) of mice home to the mammary glands of syngeneic recipients late in pregnancy and during lactation, and within hours of transfer most can be shown to contain IgA. Homing does not occur in virgins, in early pregnancy, or after weaning. Homing MN lymphoblasts are sensitive to antiserum to IgA plus complement, but not to other class-specific antisera. Thus, lymphoblasts in MN with the potential to home to the mammary gland are already committed to IgA synthesis and bear surface IgA before reaching their destination. These results explain observations, made by others, of specific IgA antibodies and IgA plasma cells in milk and colostrum after oral immunization. Under natural conditions it is likely that IgA precursor cells, after stimulation in the gut-associated lymphoid tissue by intestinal antigens, migrate to the mammary gland where they secrete antibodies which constitute an important defense mechanism of the newborn. In the absence of lactation, these cells probably form part of the normal traffic to the lamina propria of the small intestine.

Animals↗
PubMed1977

Mesenteric lymph node B lymphoblasts which home to the small intestine are precommitted to IgA synthesis.

The fate of mesenteric lymph node lymphoblasts labeled with either [125I]iododeoxyuridine or [3H]thymidine can be studied after intravenous transfer into syngeneic mice both by measurement of radioactivity in various organs and by combined immunofluorescence and autoradiography of recipient tissues. Many of the lymphoblasts home to the lamina propria of the small intestine within hours of transfer; of these, many visibly secrete IgA. To determine whether the cells that will ultimately secrete IgA are already committed to IgA synthesis before their arrival in the gut, mesenteric lymph node cell populations were treated with various class-specific antisera to mouse immunoglobulins before transfer. Treatment with antiserum to IgA, plus complement, reduced the fraction of injected label recovered from the recipients' intestines, and also reduced the proportion of donor (labeled) cells containing IgA. We conclude that mesenteric lymph nodes are probably the principal source of IgA-secreting plasma cells in the lamina propria of the gut, and that the cells become committed to IgA synthesis and develop cell surface IgA before emigrating. This IgA is apparently synthesized by the cells that bear it since it is not removed by extensive rinsing at 37 degrees C, a maneuver that elutes passively adsorbed immunoglobulin.

Animals↗