Pruritic ulcerating bruise in an elderly Hispanic man. Angiosarcoma (AS).
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Aged↗
Biomedical subjects
M Medenica
Publications and source records attributed to M Medenica.
Multiple adnexal tumors and a parotid basal cell adenoma.
A 72-year-old woman had a preauricular mass and several scalp nodules. Her medical history included excisions of multiple cutaneous tumors, including cylindromas, trichoepitheliomas, basal cell epitheliomas, and a trichilemmoma. The parotid mass and a scalp nodule were excised. On light microscopy, the parotid mass and scalp nodule appeared similar. Ultrastructural features revealed by electron microscopic analysis of the tumors allowed diagnosis of a cylindroma of the scalp and a parotid basal cell adenoma. The association of trichilemmoma and membranous basal cell adenoma of the parotid has not been previously described. The pathogenesis of these multiple cutaneous tumors from a common cell of origin is considered.
Adenoma↗
Coulometric determination of sulphisomidine, sulphamethoxydiazine and sulphamoxole.
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Electrochemistry↗
Chlorocoulometric determination of hydrocortisone and hydrocortisone acetate.
A chlorocoulometric method for the determination of small amounts of hydrocortisone and hydrocortisone acetate is presented. The method is simple and rapid, the results obtained are accurate and reproducible. It can be successfully applied to the determination of hydrocortisone and hydrocortisone acetate in pharmaceutical formulations.
Electrochemistry↗
Papulonecrotic tuberculid in a 9-year-old American girl: case report and review of the literature.
Papulonecrotic tuberculid is a rare cutaneous manifestation of tuberculosis that can also be associated with other mycobacteria. Clinically, it is an asymptomatic, recurrent eruption of papules with a necrotic center in a symmetric, acral distribution. Tubercle bacilli are not present in skin biopsies. The eruption resolves promptly with antituberculoid therapy. Few patients with this entity have been reported in the United States over the last 50 years. We report a 9-year-old, otherwise healthy, American girl whose sole initial findings were lesions of papulonecrotic tuberculid secondary to Mycobacterium tuberculosis.
Biopsy↗
Coulometric determination of levodopa, methyldopa and carbidopa.
A simple and rapid method for the assay of small quantities of levodopa, methyldopa and carbidopa is presented. The method is based on coulometric titration of the investigated substances with electrogenerated chlorine in the presence of methyl orange as indicator. Results are accurate and reproducible. The method does not require any expensive instrumentation and can be applied in any laboratory for routine analysis of these substances.
Azo Compounds↗
Multiple eccrine spiradenoma: case report and review.
Benign eccrine spiradenoma is an adnexal tumor that occurs as either a solitary lesion or as multiple nodules. A case of multiple eccrine spiradenoma occurring on the scalp and mimicking multiple cylindroma is described and discussed. In addition, 9 previously reported cases of multiple eccrine spiradenoma are reviewed.
Adenoma, Sweat Gland↗
Pigmentary changes in Seckel's syndrome.
Seckel's syndrome consists of multiple congenital anomalies, including bird-headed dwarfism, mental deficiency, and skeletal and ophthalmic defects. We report a patient with this syndrome who demonstrated pigmentary changes, including streaks of brown pigmentation on the neck, groin, and axillae. Histologic examination revealed pigment incontinence.
Child↗
Bullous eruption of diabetes mellitus.
Bullous eruption of diabetes is a cutaneous sign of diabetes mellitus. Patients with this disorder manifest a sudden onset of intraepidermal or subepidermal bullae, which are primarily confined to the extremities and heal within several weeks without scarring. Our patient had severe diabetes and experienced two episodes of bullae associated with intense, ultraviolet light exposure. Negative immunofluorescence, early disappearance of anchoring filaments and half-desmosomes between cell membrane and basal lamina, and the absence of urinary uroporphyrins separate this entity from certain similar-appearing conditions. Cation imbalance, precipitated by renal failure, could be a possible causal factor.
Adult↗
Epithelioid sarcoma: ultrastructural observation of lymphoid cell-induced lysis of tumor cells.
Epithelioid sarcoma of the palm of 7 months' duration was observed in a 30-year-old man. Six months after wide surgical excision there was no evidence of recurrence or metastasis. By light microscopic examination the tumor showed typical nodular arrangement of malignant cells, with necrosis of these cells in the centers of the nodules. Patchy lymphocytic infiltrates were observed at the peripheries of the nodules and also extended in places between the tumor cells. Other types of inflammatory cells were practically absent. By electron microscopic examination it was noted that numerous neoplastic cells formed firm close contacts with lymphocytes. Considerable numbers of neoplastic ells so contacted were damaged or even disintegrated. The damaged tumor cells contained abundant lysosomes. The release of enzymes from these lysosomes in the disintegrating tumor cells might be an important factor underlying the extracellular tissue injury and necrosis so conspicuous in epithelioid sarcoma. The very slow growth of this neoplasm and its slow tendency to metastasize might be related to the high efficacy of lymphocyte-mediated defenses against this tumor.
Adult↗
Pagetoid reticulosis (Woringer-Kolopp disease). Histopathologic and ultrastructural observations.
Histopathologic and ultrastructural observations in a case of Pagetoid reticulosis (Woringer and Kolopp disease) are reported. The most important clinical feature of this disease is manifestation as a single very slowly enlarging verrucoid, plaque-type skin lesion without internal organ involvement. Histologically, the epidermis is extremely acanthotic and densely infiltrated with numerous atypical appearing cells that are entirely absent from the dermis, which simply contains a banal dense chronic inflammatory infiltrate. Ultrastructural study showed that there are two major types of unusual cells infiltrating the epidermis. One type is a large lymphoid cell similar to the stimulated lymphocyte. The second type differs from the first in having paler staining of the nucleus and cytoplasm and showing cell membrane damage. These cells probably derive by degeneration from the large lymphoid cells. The presence of transitional forms favors this interpretation. Occasionally, degeneration of these cells proceeds to their complete necrosis.
Aged↗
Demonstration of Herpes virus by electron microscopy in the crust of a healing lesion of eczema herpeticum.
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Aged↗
Sporotrichoid leishmaniasis.
American leishmaniasis that is acquired in Panama may appear clinically as a sporotrichoid eruption. When leisons reminiscent of sporotrichosis are encountered, a careful history of the patient's travels should be made, as well as a search for the organism of leischmaniasis in tissue smears, histopathological sections, and cultured media. We report the case of an American soldier stationed in Panama who had developed an ulcer on the dorsum of his right wrist, and nodules on his right forearm that were arranged in a linear pattern. The initial clinical impression was that of sporotrichosis, but on careful study of the patient's history, and after other appropriate investigations were made, it was discovered that the patient had leishmaniasis.
Adult↗
Antigenic and morphologic regeneration of epidermal basement membrane in short term organ culture of human skin.
In fetal life the development of bullous pemphigoid antigen is preceded by a morphologically detectable basement membrane zone (BMZ). The present study investigated the possibility that similar morphologic and antigenic changes of the BMZ occur in short term organ culture of human skin. Twenty small pieces from each of four neonatal foreskin specimens were cultured under standard conditions. At regular intervals two pieces from each specimen were removed. One piece was frozen and cryostat sections were processed for indirect immunofluorescence using a patient's serum that was proven to have circulating pemphigoid IgG antibodies. Additional sections were stained with periodic acid-Schiff and hematoxylin and eosin. The other piece was processed for electron microscopic examination. Morphologically the BMZ started degenerating after 24 hours. Regeneration started on the 4th day and reached an optimal level on the 5th day. Chance of the immunofluorescence line at the BMZ began with a slight weakening at 24 hours followed by progressive widening and breakage until the 4th day when fluorescence was no longer detectable. Except for a few punctate areas immunofluorescence remained absent on the 5th day. Sixth day specimens, however, revealed reappearance of the immunofluorescence line in a continuous pattern. By the 7th day a second morphologic and antigenic degeneration started at the BMZ. This lag between the morphologic and antigenic regeneration of the BMZ in organ culture although shorter is comparable to the one observed during the development of the BMZ in fetal life.
Antigens↗
Lichen planus: an ultrastructural study.
Ultrastructural features of skin lesions are described in 11 patients with lichen planus. Keratinocytes and melanocytes in the basal layer show loss of nuclear membrane, disappearance of nucleoli, homogenization of nuclear material, and aggregation of tonofilaments around the nucleus to resemble cells in the late prophase of the mitotic cycle except that there is no clumping of chromosomes. These cells undergo fibrillar transformation to form densely packed fibrillar bodies (colloid bodies) which are the size and shape of normal cells and frequently have cytoplasmic organelles. Ten per cent of the mainly lympho-histiocytic cells in the dermal infiltrate show changes such as multiple cell membrane discontinuities, disintegration of cytoplasm, and breaks in the nuclear membrane with spilling of nuclear substance either into the cytoplasm or the extracellular space. The shape, size and occasional fibrillar changes in the nuclei and cytoplasm of these cells resemble colloid bodies. Contact sites frequently occurred between cells in the dermal infiltrate, especially between lymphocytes and macrophages. It appears that primary injury to the basal layer cells occurs during the early phase of the mitotic cycle and antigen from this primary site may evoke a cell-mediated type of hypersensitivity reaction. Colloid bodies evolve from cells which have injured nuclei and undergo fibrillar transformation. Dermal as well as epidermal cells may contribute to colloid body formation.
Cell Nucleolus↗
[Pericardial cysts as a problem in differential diagnosis].
Pericardial cysts are usually located in the cardiophrenic corners, most frequently to the right, in the front lower mediastinum. Clinically, their course is usually asymptomatic. They are divided into connatal and acquired pericardial cysts. Preoperatively they are often unexpected, especially in the case of unusual locations. Our work deals with two cases of pericardial cysts. The first case treats a connatal pericardial cyst located supradiaphragmatically, which was described in the literature of 1929, in connection with 7 patients. The second case dealt with the acquired cystic formations of the pericardium due to the uncured specific pericarditis. This patient developed clinical appearance of the pericardial tamponade. Therefore, pericardial cysts, although statistically rare, cannot be neglected in the everyday pneumological and internal medical practice.
Adult↗