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Biomedical subjects

M Meglio

Publications and source records attributed to M Meglio.

At least 73 records · Page 4Linked to original sources
PubMed1981

The role of percutaneous cordotomy in the treatment of chronic cancer pain.

The authors report on 53 cervical percutaneous cordotomies in 52 patients suffering from chronic unilateral cancer pain. The evaluation of the results is based upon the patient's report of complete pain relief. Immediate and long term pain relief as well as complications and mortality rate are analysed. Excellent surgical results were obtained in 73% after one week and in 63% 15 weeks after operation. The topographical distribution of pain seems to influence the pain relief; the location of the cancer does influence the nature of the complications. Furthermore, the occurrence of other pain syndromes, controlateral to or above the level of analgesia, is evaluated. This appears to be an important limitation of the usefulness of cordotomy.

Adult↗
PubMed1980

Epidural spinal cord stimulation for the treatment of neurogenic bladder.

The effect of percutaneous epidural spinal cord stimulation on neurogenic bladder has been evaluated on the basis of objective clinical and urodynamic criteria. Seven patients suffering from stable bladder and sphincter dysfunction due to spinal cord diseases of different causes of non-evolutive nature were examined. In some of them chronic pain or substantially improved micturition in six of our seven patients. Complete or almost complete relief of bladder spasticity, marked increase of bladder capacity, and reduction or abolition of residual urine were recorded. The beneficial effect on bladder and sphincter function is strictly dependent on the stimulation, though it can outlast it. It requires some weeks to reach its maximum. It is still obtained after 22 months of treatment (longest present follow-up). No changes of straital activity and detrusor reflex were produced by spinal cord stimulation in two additional patients, treated for chronic pain but having intact bladder function.

Adult↗
PubMed1977

beta-Endorphin: behavioral and analgesic activity in cats.

beta-Endorphin has been shown to possess potent behavioral and antinociceptive activities when administered intraventricularly in cats. On a molar basis, beta-endorphin is 72-96 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone.

Analgesics↗
PubMed1977

beta-Endorphin: development of tolerance and its reversal by 5-hydroxytryptophan in cats.

Tolerance to beta-endorphin developed acutely in cats if the administration of the peptide was repeated within the first 24 hr. The tolerance was reversed immediately by systemic administration of the serotonin precursor, 5-hydroxytryptophan. It was further shown that 5-hydroxytryptophan potentiates the analgesic effect of the subliminal dose of beta-endorphin.

5-Hydroxytryptophan↗
PubMed1976

Interaction of epileptic activities of bilateral deep temporal origin. An experimental study.

The interaction of epileptic activities obtained with electrical or chemical (penicillin) stimulation of the amygdaloid nuclear complexes of the two sides was studied in acute experiments on the rabbit. Several findings indicate that reciprocal influences between the two epileptogenic amygdalae can occur. Inhibitory as well as facilitatory interactive phenomena were observed. The occurrence of interaction and its sign seem related to the level of epileptic activity.

Amygdala↗
PubMed1976

Experimental bilateral deep temporal epilepsy. Effects of ablation of one focus and of different brain lesions.

In acute experiments in the rabbit, the amygdaloid nuclear complexes of the two sides were made epileptogenic through electrical stimulation or local injection of penicillin in gel. The effects on the epileptic pattern produced by surgical removal of one of the two epileptogenic amygdalae and the effects of sterotactic lesioning of the region of anterior commissure, head of caudate nucleus, and occipital cortex were analyzed. The occurrence of phenomena of both inhibitory and facilitatory interaction between the two epileptogenic amydalae was confirmed. In some experimental conditions, the restraining influence of an amygdaloid penicillin focus on the contralateral one was quite relevant, and its effect could persist even after surgical removal of the focus from which it originated. The mediation of the interamygdadoid epileptic interaction could not be ascribed to a single cerebral structure or anatomofunctionally homogenous group of structures. The phenomenon appears to involve several structures at different encephalic levels.

Amygdala↗
PubMedDate not supplied

[Experimental comparative study on the antiepileptic effect of clonazepam, sodium dintoine and phenobarbital administered parenterally].

A comparative study of the antiepileptic action of Clonazepam, phenythoin-natrium and phenobarbital has been performed in acute experiments in rabbits. The effort of the three drugs, administered intravenously, was studied on a) the epileptic activity induced by electrical stimulation of the amygdala, b) the interictal and c) ictal epileptic activity of an amygdaloid chemical focus (penicillin in gel). Clonazepam has a definite higher capacity, than the other drugs examined to prevent or to reduce the phenomenon of generalization of epilepsy. However, its effect has a shorter duration.

Animals↗
PubMedDate not supplied

L-DOPA treatment of comatose states due to cerebral lesions. Preliminary findings.

The results of a study on the effects of L-Dopa in brain-injured patients showing impairment of consciousness are reported. Fifteen patients were selected for this study. The degree of consciousness impairment, or level of coma, varied in the different patients. In all of them, however, the comatose state persisted unchanged for at least 6 days before the beginning of L-Dopa treatment. A gradual and progressive improvement of the level of consciousness, as well as of the EEG patterns, followed the administration of L-Dopa in patients whose treatment commenced while they were in comas III, II and I (classification of Fishgold and Mathis, 1959, and Rossi, 1962). On the other hand, the results of the treatment were questionable in the sequelae of coma (apallic syndrome, coma vigil, akinetic mutism). A direct relation between L-Dopa and consciousness improvement appears to be supported by: 1) the fact that the level of coma was stabilized for several days prior to L-Dopa treatment (see above); 2) the fact that consciousness improvement occurred abreast of L-Dopa dosage; 3) the observation in some patients that worsening followed the temporary withdrawal of L-Dopa treatment and, vice-versa, improvement followed its resumption. The hypothesis of neurochemical components in the processes responsible for the decrease of vigilance following cerebral injury would appear supported by the findings reported.

Brain Injuries↗