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Biomedical subjects

M Melato

Publications and source records attributed to M Melato.

At least 73 records · Page 4Linked to original sources
PubMed1984

Incidence of hepatocellular carcinoma in the Trieste area over a 15-year period (1968-1982).

An analysis of 26,700 unselected autopsies performed consecutively over a 15-year period was made to establish the incidence of hepatocellular carcinoma (HCC) and its relationship to cirrhosis of the liver in the Trieste area. In our series, considering the period 1968-1980, the average value of the annual age and sex incidence rates of HCC standardized to the European population proved to be 10.58/100,000 in cirrhotic males and 1.3/100,000 in cirrhotic females, whereas in non-cirrhotics it was 1.14/100,000 and 0.34/100,000, respectively. In cirrhotic males autopsied during the period 1977-1980 the above incidence increases, its average value being 16.53/100,000.

Adult↗
PubMed1983

Amyloidosis of specialized mesodermal tissues in non-myelomatous monoclonal gammopathy. A pathogenetic hypothesis.

The follow-up and the pathological findings of a previously described case of non-myelomatous monoclonal gammopathy with relapsing localized amyloid masses of the shoulder joints are reported. The peculiar "mesodermal" distribution of amyloid deposits, strictly limited to tissues lined by mesothelial or endothelial cells emphasizes the role of local factors in the pathogenesis of amyloidosis thus supporting the hypothesis that amyloid deposition can be related also to some differentiated tissues with peculiar local susceptibility. The morphological findings of the present case enable the Authors to suggest a pathogenic mechanism for amyloid deposition.

Aged↗
PubMed1982

Inaccuracy of death certificate diagnoses in malignancy: an analysis of 1,405 autopsied cases.

In 1,405 patients who died at the General Hospital of Trieste in 1974 and 1978, malignant neoplasm was revealed at autopsy. Clinical diagnosis was accurate in 54 per cent of these patients. The tumor was clinically suspected in 19 per cent and was undiagnosed in 27 per cent. The accuracy of the clinical diagnoses varied significantly according to the primary site and type of tumor; accuracy was inversely related to the age of the patient and varied also according to the department of the hospital to which the patient had been admitted. This latter variation is age-dependent, too. In the past decades clinical diagnosis of malignancy has not greatly improved, although the autopsy rate has almost everywhere strongly decreased, representing a heavy handicap in the epidemiologic research on cancer as a cause of death.

Age Factors↗
PubMed1980

Pulmonary fibrosis following low-dose 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) therapy.

Two women, 65 and 55 years old, with metastatic malignant melanoma, were treated with low doses of BCNU for a short period (six and three months, total dose 2500 and 2000 mg). Both patients developed pulmonary fibrosis, which was visible in postmortem examination. In the first woman, lesion development was so widespread as to be considered responsible for death. Because chest x-ray before treatment was not abnormal, we consider BCNU capable of inducing the lesion.

Aged↗
PubMed1980

Amyloid casts within renal tubules: a singular finding in myelomatosis.

This study was carried out in order to investigate a possible relationship between multiple myeloma and the occurrence of material exhibiting the properties of amyloid within renal tubules. Two groups of autopsied patients, with myelomatosis and benign monoclonal gammopathy were examined for the presence of amyloid deposits in renal and extra-renal sites. Urines were analysed for the presence and amount of Bence Jones protein and the pattern of the associated proteinuria was characterized. Renal tubular casts exhibiting the histochemical characteristics of immuno-amyloid were found exclusively in myeloma patients with Bence Jones proteinuria but without the renal lesions classically described as "myeloma kidney". This finding was independent of the occurrence of immuno-amyloid deposits in other renal and extra-renal sites, suggesting involvement of local factors in the pathogenesis of amyloid formation and deposition within renal tubular lumina. The results of present study suggest the conclusion that the presence of amyloid intratubular casts is to be regarded as a peculiar finding in myelomatosis.

Aged↗
PubMed1980

Pseudotumoral (para-articular) amyloidosis in non-myelomatous monoclonal gammopathy.

A case of non-myelomatous monoclonal gammopathy, with the unusual presenting features of recurrent "pseudotumoral" localized amyloid deposits in intimate relation with the shoulder joints, is described. The peculiar anatomo-clinical features, which make this case quite different from the most reported ones of amyloid arthropathy and of localized amyloidosis, are discussed. The pathogenetic implications are analyzed with special reference to the various known mechanisms, none of which seems to provide a completely satisfactory explanation of the genesis of this form.

Aged↗
PubMed1980

Nodular lymphoma eventuating into lymphoplasmocytic lymphoma with monoclonal IgM/lambda cold agglutinin and Bence-Jones proteinuria.

A case of nodular lymphocytic (centroblastic/centrocytic) lymphoma that developed within 5 months after the initial diagnosis of lymphoplasmocytic lymphoma is described. The change in the histopathological picture, consisting of the development of a functionally more differentiated B cell neoplasm, occurred in the abdominal lymph nodes while the original pattern persisted in the bone marrow, liver and spleen. The patient was also found to have a serum IgM/lambda monoclonal immunoglobulin exhibiting cold agglutinin activity with specificity for the 'non-I' erythrocyte antigens.

Agglutinins↗
PubMed1980

Pathology of ocular tissues in amyloidosis.

Ocular involvement was found in 29 autopsied individuals with generalized vascular amyloidosis. It may be present both in clinically primary and secondary amyloidosis. In the latter form the choroid and the sclera are particulary involved, whereas in the orbit the most frequently affected tissues in both forms are the extraocular muscles. However, in most cases amyloid deposits are localized in the vessels of the aterial circle of Zinn-Haller. The retina showed no involvement in 28 of 29 cases while optic nerve fibres never were affected. The optic nerve dural sheath was slightly involved in 8 cases.

Aged↗
PubMed1979

Amyloidosis of the pancreas: histochemical differentiation between insular and extrainsular deposits.

The results of a study of eighty-two human pancreases affected by deposits of amyloid in the islets of Langerhans are presented. Two different types of amyloid deposits were observed, one affecting the exocrine tissue and the other affecting the islets. These deposits were found to be histochemically different and appeared to indicate two different aetiopathogenetic processes. The deposit found in the exocrine tissue is essentially perivascular and might be considered an extension to the pancreas of a systemic amyloidosis of the "senile type"; the islet deposits appear to be a completely different phenomenon that could become part of the biology and pathology peculiar to the so called APUD system. The coexistence of the two types of amyloid in the human pancreas would seem, therefore, to represent a casual event.

Aged↗