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Biomedical subjects

M Merkel

Publications and source records attributed to M Merkel.

At least 55 records · Page 3Linked to original sources
PubMed1984

Computed tomography of upper aerodigestive tract squamous cell carcinoma. Assessment following induction chemotherapy.

One hundred forty-seven previously untreated patients with stage III or IV upper aerodigestive tract squamous cell carcinomas were examined by computed tomography (CT) prior to treatment. Computed tomography was used to observe the tumor response in 72 patients receiving induction chemotherapy (100 mg/sq m of cisplatin on days 1 and 21 and 135 mg/sq m of bleomycin sulfate on days 3 through 10). The CT findings in ten patients were correlated with serial histologic examination of the operative specimens. Our study indicates that CT is useful in following tumor response to chemotherapy, provided the physician is aware of the limitations of scanning as outlined herein.

Carcinoma, Squamous Cell↗
PubMed1982

Computed tomographic assessment of squamous cell carcinoma of oral and pharyngeal cavities.

Computed tomographic (CT) scans were prospectively obtained on 68 patients with previously untreated stages III and IV squamous cell carcinoma of the oral and pharyngeal cavity. We report herein the results of CT evaluation of primary disease arising in these sites, improvements in contrast-enhancement techniques, and CT assessment of the patient's condition after radiation or chemotherapy treatment.

Biopsy↗
PubMed1981

Total columnar-lined esophagus: a case for congenital origin?

We describe a patient with a long history of hiatal hernia, who at autopsy was found to have an esophagus that was totally lined by columnar epithelium. To our knowledge, this is the first documented case of an esophagus totally lined by columnar epithelium in an adult. Recent articles have emphasized the acquired nature of Barrett esophagus, also known as lower columnar-lined esophagus. Several reports have shown the ascent of columnar mucosa from the lower to middle esophagus over time. The failure of the columnar epithelium lining the esophagus to revert back to squamous type, once the irritating stimulus is removed, casts doubt on the metaplastic nature of this lesion. We believe that Barrett esophagus in a condition characterized by persistence of fetal-type epithelium and that our case represents such an occurrence.

Barrett Esophagus↗
PubMedDate not supplied

Computed tomographic evaluation of regional lymph node involvement in cancer of the oral cavity and oropharynx.

To evaluate the efficacy of computed tomography (CT) in the identification of metastatic cervical node involvement from cancer of the oral cavity and oropharynx, 61 consecutive, previously untreated patients with T2 or greater squamous cell carcinoma of these sites were studies prospectively by CT, followed within 1 month by surgery to the primary and neck as initial treatment. The CT scan of each patient was evaluated according to the location, size, and appearance of visible nodes, and each feature was correlated with the histopathologic findings of all 83 neck specimens. A significant relationship was found between CT findings (node size, node appearance, and multiplicity of nodes) and the pathologic status of the neck using Chi-square contingency table analysis (overall chi 2 = 30.928, p less than 0.001). This data supports the role of CT in the evaluation of patients with cancer of these sites.

Adult↗
PubMedDate not supplied

Cricoarytenoid subluxation, computed tomography, and electromyography findings.

A case of cricoarytenoid subluxation secondary to endotracheal intubation and documented by computed tomography (CT) and electromyography (EMG) is reported. Successful endoscopic reduction of the displaced arytenoid is confirmed by CT. The normal anatomy and physiology of the cricoarytenoid joint is presented and the literature regarding this rarely reported injury is reviewed. Based on this review and the case reported, a treatment plan is proposed.

Arytenoid Cartilage↗