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Biomedical subjects

M Merle

Publications and source records attributed to M Merle.

At least 145 records · Page 8Linked to original sources
PubMed1984

The repair of peripheral nerve injuries in emergency.

Peripheral nerve injuries must be considered as serious surgical emergencies for they are often associated with vascular lesions. Primary repair of clean-cut injuries of peripheral nerves by microsurgical techniques yields better results than the best of secondary repairs.

Electromyography↗
PubMed1984

[Irreducible closed luxation of the distal interphalangeal joint. Apropos of 2 cases].

Two irreducible dislocations of the distal digital interphalangeal joint have been seen by the author. One was dorsally displaced with interposition of the extensor tendon, and the other was a palmar displacement with interposition of the flexor tendon. Both cases were successfully treated by open reduction. A review of the literature confirms the rarity of this condition.

Adult↗
PubMed1983

[An unusual form of macrodactylia].

The authors report a rare case of macrodactyly of the thumb in a 36 year old woman. The hypertrophy predominates on the epiphyseal tissue with complete ankylosis of the trapezo-metacarpal metacarpo-phalangeal, and interphalangeal joints in an abnormal position. This results in total functional incapacity of the thumb. The cosmetic and psychological impact are important to consider. Treatment consisted of two operative procedures. First a silastic implant for the trapezo-metacarpal joint and an arthrodesis of the metacarpophalangeal joint in a normal position was done. Three months later, the volume of the thumb was reduced by a longitudinal bone resection. The functional and cosmetic result is assessed. The literature is reviewed and the different modes of treatment utilized in such a malformation are presented. A relation between macrodactyly and lipomatous macrodystrophy is considered.

Adult↗
PubMed1983

On the mechanism of tRNATrp aminoacylation catalysed by beef tryptophanyl-tRNA synthetase using presteady-state kinetics.

The dimeric tryptophanyl-tRNA synthetase from beef pancreas has been found to activate 2 tryptophans/mol enzyme [Eur. J. Biochem. (1982) 128, 389-398]. By using quenched-flow and stopped-flow methods under presteady-state conditions, we show that only one enzyme subunit operates at a time in the aminoacylation of tRNATrp and that the transfer reaction is not the rate-limiting step in the overall aminoacylation process.

Amino Acyl-tRNA Synthetases↗
PubMed1983

Fascicular nerve graft using an empty perineurial tube: an experimental study in the rabbit.

An experimental model of a free, empty perineurial tube for use as a nerve graft is presented as an alternative to existing methods. The technique is described and the model compared with conventional nerve graft in the sciatic nerve of a rabbit. Results are evaluated with EMG studies, angiography, and histology. The experimental model compared favorably with the standard graft. Further avenues of investigation and clinical use are suggested.

Angiography↗
PubMed1982

Kinetic anticooperativity in pre-steady-state formation of tryptophanyl adenylate by tryptophanyl-tRNA synthetase from beef pancreas. A consequence of the tryptophan anticooperative binding.

The kinetics of formation of tryptophanyl adenylate by tryptophanyl-tRNA synthetase from beef pancreas has been followed by stopped-flow, using the quenching of fluorescence of the enzyme linked to the amino acid activation reaction. Both subunits of this alpha 2 enzyme catalyze the adenylate formation. At saturation with substrates the rate constant of the activation reaction is the same for both subunits. The same behaviour is observed for the pyrophosphorolysis reaction. Both subunits exhibit the same affinity for ATP-Mg in the forward reaction and the same affinity for magnesium pyrophosphate in the backward reaction. On the contrary the formation of tryptophanyl adenylate follows biphasic kinetics when tryptophan concentration is much below saturation. This is independent of ATP-Mg concentration and is the consequence of different affinities of the two subunits for tryptophan as already observed by Graves et al. (1979, Eur. J. Biochem. 96, 509-518) in equilibrium dialysis experiments. A monoadenylate-enzyme complex on one subunit has been prepared. This complex made possible the study of the formation of the second adenylate on the other subunit. The formation of this second adenylate followed first-order kinetics at all ATP-Mg and tryptophan concentrations. The tryptophan concentration dependence of the rate of formation of this second adenylate leads to a Michaelis constant close to the dissociation constant of the low affinity tryptophan site of the enzyme. No isomerization step could be evidenced. The experiments were carried out under two conditions corresponding to those used by Merault et al. (1978. Eur. J. Biochem. 87, 541-550) in the steady state of the tRNATrp aminoacylation reaction (10 mM total magnesium in 100 mM KCl and 1 mM free magnesium ions, both at pH 8.0.25 C). No great difference either in the mechanism or in the dissociation and rate constants was observed but an inhibitory effect of KCl. It is concluded that the enzyme is symmetrical as far as the ATP-Mg and the magnesium pyrophosphate sites are concerned and that the rate of the activation reaction reflects the anticooperative occupancy of the tryptophan sites carried by the two subunits.

Adenosine Monophosphate↗
PubMed1982

[Subcutaneous angioma of the hand].

The authors describe the specific features of hemangiomas of the hand in adults (three cases). The clinical syndrome is described. The main examination is by arteriography of the hand which shows three principal aspects: the vascular topography; the volume of the tumors; the extension of the neighbouring tissue. The treatment is analysed: surgical exeresis; in some cases, microvascular transplants are necessary (especially for the distal reconstruction of a finger); embolization is normally avoided because of the risk of necrosis of the finger.

Adult↗
PubMed1982

[Malunions of the metacarpals and phalanges. Results of surgical treatment].

The authors have made an analysis of the results obtained after surgical correction of 30 malunited metacarpals and phalanges. Nine involved joints, but the remainder did not. In 25 cases, there was limited movement associated with the malunion. The surgical devices were specially designed for surgical treatment and the technique employed is described. It is concluded that the correction of malunion needs to be made but that this alone is not sufficient to obtain a satisfactory result. The effectiveness of added tenolysis, arthrolysis, post-operative bracing and rehabilitation is even more important. The indications for treatment are given according to the level and location of the malunion.

Adolescent↗