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M Michalska

Publications and source records attributed to M Michalska.

23 records · Page 2Linked to original sources
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Blood coagulation changes in rats poisoned with methylmercuric chloride (MeHg).

The effects of methylmercuric chloride on the coagulability of blood were studied in rats. The administration of a single dose (17.9 mg Hg/kg) and a repeated dose (5 X 8 mg Hg/kg/day) of this compound resulted in hypercoagulation. The reduction of the clotting time, the increase of fibrinogen level in plasma and changes characteristic of hypercoagulation in the thromboelastographic parameters were observed. Simultaneously, signs of impaired activity of blood platelets: decreased aggregation velocity and clot retraction as well as prolongation of the bleeding time were noticed.

Adenosine Diphosphate↗
PubMedDate not supplied

Coagulation and fibrinolysis in rats poisoned with mercuric chloride.

The effect of mercuric chloride on blood coagulation and fibrinolysis in rats was studied. The mercurial was administered to the animals intragastrically in a single dose of 17.9 mg Hg/kg and the effects were tested on the 1st, 3rd and 7th day. The symptoms of hypercoagulability accompanied by decreased fibrinolytic activity of the plasma were observed in the poisoned rats. The main reason of the lowered fibrinolytic activity seemed to be the inhibition of plasma plasminogen activator or the inhibition of plasminogen activation reaction catalyzed by this enzyme.

Animals↗
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Plasma and platelet fibrin-stabilizing factor activity in rats intoxicated with phenylmercuric acetate.

Effect of phenylmercuric acetate on the activity of rat plasma and platelet fibrin-stabilizing factor (FSF) was studied. The mercurial was administered to the animals intragastrically in a single dose of 17.9 mg Hg/kg or in repeated doses of 1.79 mg Hg/kg, twice a week for 152 days. The activities of the investigated fibrin-stabilizing factors were significantly increased in the case of intoxicated rats. Such an effect was observed in both types of the exposure.

Animals↗