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Biomedical subjects

M Midulla

Publications and source records attributed to M Midulla.

99 records · Page 6Linked to original sources
PubMedDate not supplied

[Epidemic parotitis in Italy: results of a 1st vaccination trial].

Forty children over 12 months of age were inoculated subcutaneously with live mumps vaccine (Jeryl Lynn strain) and tested before and 6 weeks after vaccination for complement fixing, (CF) and hemadsorption neutralizing (HN) serum antibodies against a wild-mumps virus strain. CF antibody titers were not reliable for assessing both the previous immunity and the vaccine response. Among the 13 HN seronegative subjects the responders to the vaccine were 7, with a seroconversion rate of 53.8% and a geometric mean titer (GMT) of 1:2.6. Twenty (74.1%) of the 27 subjects already seropositive before the vaccination had a booster effect with an increase of the GMT from 1:8.29 to 1:33.89.

Antibodies, Viral↗
PubMedDate not supplied

[Vaccination against epidemic parotitis].

Parotitis is usually a mild illness infrequently associated with severe complications, such as encephalitis, deafness or orchitis. The early studies of mumps vaccine (1940-1950) led to the development of killed virus preparations, which offered quite weakly protective immunity. Subsequently, attenuated live virus vaccines became available. These vaccines are more immunogenic and can be used mixed with measles and rubella vaccines. The widespread use of mumps vaccine in the United States has caused a dramatic reduction of the disease, with concomitant decrease of its complications. Although this may be explained by the vaccine-induced seroconversion (in over 95% of cases), the duration of protection is still unclear, since it is theoretically possible that after mumps immunization the infection could occur in older age-groups.

Antibodies, Viral↗
PubMedDate not supplied

[Kawasaki's syndrome: description of 4 cases].

In this study we present four cases of Kawasaki syndrome; in two of them were present some particular aspects, besides the characteristic signs of the lymphonodal-mucocutaneous syndrome. One little girl showed, during the acute phase of the disease, paralysis of facial nerve, without other signs of neurological involvement; in the second patient, the outcome of the syndrome was quite atypical, because of an osteoarticular involvement; we also observed the presence of immature white blood cells in the peripheral blood. Three of the four cases were treated with acetyl-salicylic acid for almost one year, two of them were also treated with dypiridamol. A four years follow-up, after the acute phase, demonstrated a complete recovery, a normal clinical status and no damage of the cardiocirculatory system.

Blood Cells↗
PubMedDate not supplied

[A simplified micromethod for the measurement of leukocyte candidacidal activity (author's transl)].

A technicall simple micromethod for the assessment of leukocyte candidacidal activity is described. It is based on the alterations in Giemsa staining characteristics which Candida albicans cells develop when ingested by glass-adhering phagocytes. This method, which requires small quantities of whole blood and produces reliable results, may be of promising clinical usefulness for detecting primary and secondary phagocyte candidacidal defects in patients with chronic or recurrent localized and systemic candidiasis.

Antibody Formation↗