Biomedical subjects
Publications and source records attributed to M Mikulecký.
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The mathematical model of hepatobiliary transport of indocyanine green in man was extended by modeling the dye injection and its mixing in blood plasma, too. The time constant of mixing and five coefficients characterizing the dye transport among blood plasma, liver cells, bile and intestine were estimated by methods based on adaptive systems of identification. The resulting plasma disappearance curve of indodyanine green has three distinct phases with successively decreasing rate of clearance. The estimated values of five inconstant rate coefficients do not differ substantially from those for constant coefficients. The findings support the validity of previous calculations estimating liver uptake, storage and excretory function, bile storage function and dye transport from bile into intestine. The usefulness of system approach in this field is stressed.
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The plasma clearance of indocyanine green (Cardio-Green, 0.5 mg/kg body weight) was studied in a total of 352 plasma samples from 7 male and 8 female healthy volunteers, and total bilirubinaemia in 6 males and 6 females. Statistical analysis (linear regression, SAAM programmes by BERMAN and WEISS [2],t-test. F-test and rank correlation) disclosed a significantly higher plasma disappearance rate of indocyanine green and significantly lower total bilirubinaemia in females than in males with a statistically almost significant negative correlation of both phenomena. A better excretion of indocyanine green from liver to bile in males though statistically significant could be an artefact caused e.g. by a not quite significant abnormally of the calibration straight line of the dye.
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