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Biomedical subjects

M Mikulecký

Publications and source records attributed to M Mikulecký.

131 records · Page 8Linked to original sources
PubMedDate not supplied

Cosinor demonstration of circatrigintan (circavigintan) biorhythm in cell component volume of female urethral ejaculate.

In urethral expulsions of a multipara, aged 37 years, induced by digital stimulation over a time span of almost one and a half 26-day menstrual cycle, the volume of desquamated cellular component changed, according to two nearly identical versions of cosinor, with the period of 22-27 days, with the acrophase between 17th and 23rd day of menstrual cycle and with the amplitude between 0.5 and 1.2 ml/day. The issue testifies to periodic quantitative changes in squamous cells of vaginal type in female urethra, large paraurethral ducts and trigone of the bladder during menstrual cycle, with maximal desquamation during its secretory phase. A link on stop function of urethral epithelium and thus on female miction problems is suggested.

Adult↗
PubMedDate not supplied

Circannual periodicities in the incidence of ulcerative colitis do persist in the era of chemotherapy.

A series of 274 attacks (256 of them recurring) of ulcerative colitis in 158 subjects, observed between January 1974 and December 1990 in Bratislava (48 degrees N, 17 degrees E), Slovakia, has been processed by R.A. Fisher's periodogram and F. Halberg's cosinor procedure. In spite of the long-term administration of sulfasalazin and/or corticosteroids, an unequivocal statistically significant (alpha = 0.01) annual (P = 0.0003) rhythmicity was identified. The amplitudes of both cycles were very similar, approximately 25% of the MESOR. The first estimated peak occurred in the second half of March and the first half of April, with an estimated increase of more than 50% over the average monthly incidence, resulting from coincident acrophases of both components. The second semiannual peak occurred at the end of September and early October. It is concluded that the long-term chemotherapy, applied in the majority of cases, failed to substantially influence the known circannual variations of the disease attacks. The issue has to be taken into account in planning prevention measures, treatment and its evaluation, as well as in organizing the regimen of management in endoscopic centers.

Acute Disease↗
PubMedDate not supplied

In defense of proper cosinor analysis.

Parallaxes can originate from different sources, from bias towards proving a favored hypothesis, but also from bias against existing evidence in support of an unwanted hypothesis. One approach to avoiding either bias is to shift emphasis from hypothesis testing to parameter estimation. Complementary statistical approaches applied to replicates of given experiments can then serve to further a given field of science by providing converging or diverging results depending on whether the original hypothesis was true or false.

Acetabularia↗