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M Miller-Andersson

Publications and source records attributed to M Miller-Andersson.

12 recordsLinked to original sources
PubMed1978

Unreliability of chromogenic substrates for assay of the clotting activity of thrombin.

The rapid loss in clotting activity of commercially available thrombins during storage is not reflected by their activity as measured by synthetic chromogenic substrates. It is suggested that conformational changes occurring during storage can affect the binding sites of thrombin for fibrinogen, whereas small synthetic substrates are incapable of monitoring these changes.

Animals↗
PubMed1978

Microheterogeneity in thrombin standards.

Potency estimations of thrombin have been performed using clotting and synthetic substrates in parallel assays. The International Standard and the Nordic Standard of thrombin have both been used as references. Divergencies in estimated unitage necessitated a study on possible heterogeneities in the standard preparations presented in this paper.

Animals↗
PubMed1976

The effect of antithrombin III on the activity of the coagulation factors VII, IX and X.

Antithrombin III, purified to homogeneity according to polyacrylamide gel disc electrophoresis and immunoelectrophoresis, inhibited the activity of purified factor IXa and Xa, whereas factor VII was not inhibited either in the active or in the native form. Antithrombin III is the single most important inhibitor of factor Xa in plasma. Factor Xa does not, however, reduce the activity of antithrombin III against thrombin.

Antithrombins↗