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Biomedical subjects

M Milosavljević

Publications and source records attributed to M Milosavljević.

8 recordsLinked to original sources
PubMed1997

Prognostic factors: classification approaches in patients with lung cancer.

With the proliferation of potential prognostic factors for lung cancer, it is becoming increasingly more difficult to integrate the information provided by these factors into a single accurate prediction of clinical outcome. Here we reviewed five classification methods for their capabilities in classification of 200 patients with lung cancer into distinct prognostic groups using survival outcome as a criteria. The source of patient data for this study is a Lung Tumour Registry from Institute for Lung Diseases, University Clinical Hospital, Belgrade. Almost all developed classification algorithms determined prognostic groups according to biochemical tumour markers LDH and alkaline phosphatase, producing most significant split, instead of commonly used staging variables. The choice of which approach to use for a given classification problem depends not only on statistical properties of method, but also on medical considerations, such as whether more differential findings are given greater weight and the applicability of a classification rule.

Alkaline Phosphatase↗
PubMed1996

[Idiopathic membranoproliferative glomerulonephritis (structural-functional relationship)].

We investigated 12 patents with idiopathic membranoproliferative glomerulonephritis. Discriminatory analysis was used for structural functional relationship in order to determine discriminatory power of certain clinical and pathohistological parameters. Semiquantitatively were determined pathohistological parameters: glomerular index in range 0-10, vascular index 1-4, interstitial fibrosis 0-10, interstitial infiltration 0-3, tubular atrophy 0-3. Nephrotic syndrome (symbolic value), quantitative proteinuria and creatinine clearance (continual variable) were used as clinical parameters. Discriminatory power was determined as a degree of decreasing Shennon's entropy dy distinction of patients according to value of creatinine clearance at the time of biopsy. Discriminatory power was measured in the information measurement units (bit). The most powerful was glomerular index (discriminatory power 0.29) in moderately reduced glomerular filtration rate (creatinine clearance 80 ml/min) at the time of biopsy. In severely reduced glomerular filtration rate (creatinine clearance 40 ml/min) vascular index had the greatest discriminatory power (0.24) while interstitial infiltration and interstitial fibrosis had less powerful discriminatory power (0.13). Negative predictive value of reduced glomerular filtration rate at the time of biopsy in membranoproliferative glomerulonephritis has been confirmed in other studies.

Adult↗
PubMed1996

[Renal function and histologic findings in immunoglobulin A nephropathy].

We investigated 28 patients with IgA nephropathy. Discriminatory analysis was the method used to determine discriminatory power of certain clinical and pathohistological parameters. Semiquantitatively were determined pathohistological parameters: glomerular index in range 0-10, vascular index 1-4, interstitial fibrosis 0-10, interstitial infiltration 0-3, tubular atrophy 0-3. Nephrotic syndrome (symbolic value), quantitative proteinuria and creatinine clearance at the time of biopsy and year after (continual variable) were used as clinical parameters. Discriminatory power was determined as a degree of decreasing Shennon's entropy by distinction of patients according to value of creatinine clearance at the time of biopsy, and a year after biopsy. Discriminatory power was measured in he information measurement units (bit). Based on discriminatory-predictive analysis we determined that glomerula changes and interstitial fibrosis had an equal effect (discriminatory power) on renal function at the time of biopsy and a year latter, as well as predictive value of these histological parameters and creatinine clearance at the time of biopsy.

Adult↗
PubMed1989

[Anterior retrosternal diaphragmatic hernia].

The authors in their work present a case of the anterior retrosternal diaphragmatic hernia in a 18 months old child which they have successfully operated on after they had discovered it accidentally by a roentgen examination. On that occasion they examined embryology and clinical aspects of this unusual congenital anomaly.

Female↗
PubMed1989

[Splenic injuries in children].

The authors have analysed their experience in treating spleen injuries with children in this institution. From 1970 up to 1988, 22 children were operated upon and splenectomy was done in all the children (5 isolated and 17 united spleen injuries), there were 3 autotransplantations of spleen parts in omentum and 1 case of surgical spleen conservation. Only one operated child died soon after the operation because of a polytrauma and shock. Besides local festering there were not recorded any other cases of infection and sepsis with these and other children operated on within last 25 years. A child's injured spleen should be preserved of course but not at the cost of life, if there are no conditions. A child should be given a chance to live even without the spleen.

Adolescent↗
PubMed1983

[Early necrectomy, homo- and autotransplantation of skin in a 19-month-old child with deep burns over 45% of the body].

The authors present a case of a 19 months old baby, twin, with deep burns (45% of the skin), caused by boiling beans. The child was transported to the hospital immediately after the injury. Following the successful anti-shock therapy (whose scheme has been given), the child was operated upon on the VI day: early necrectomy with homotransplantation of his father's skin. In the second stage an autotransplantation (Thiersch) has been performed. The transitory complications were a melaenå appearing on the VII day, and later a contracture of the elbow. Finally, the child left the hospital with no Keloid formations or functional deficit.

Burns↗