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Biomedical subjects

M Milstoc

Publications and source records attributed to M Milstoc.

At least 19 recordsLinked to original sources
PubMed1985

Rapidly progressive glomerulonephritis in a patient with rheumatoid arthritis during treatment with high-dosage D-penicillamine.

A patient with advanced rheumatoid arthritis and severe clinical manifestations of rheumatoid vasculitis died of acute renal failure after 30 months of treatment with high-dosage D-penicillamine. She had had no signs of adverse drug reactions until the terminal illness. Although streptococcal pharyngitis was diagnosed late in her disease, penicillamine-induced immune complex glomerular damage is considered more likely than poststreptococcal glomerulonephritis, because her microscopic hematuria preceded diagnosis of pharyngitis. Postmortem examination disclosed findings suggestive of rapidly progressive glomerulonephritis of immune complex pathogenesis. The short period of microscopic hematuria and the rapidity of development of renal failure before death emphasize the need for frequent monitoring of renal function and prompt discontinuation of D-penicillamine treatment upon detection of otherwise unexplained hematuria. There is urgent need for early immunological evaluation, renal biopsy, and vigorous therapeutic measures.

Arthritis, Rheumatoid↗
PubMed1980

A unique outbreak of Pasteurella multocida in a chronic disease hospital.

An outbreak of Pasteurella multocida infection, involving seven patients on two adjacent wards, has been observed. All seven patients were debilitated and had underlying chronic neuromuscular and/or pulmonary disease and had a tracheostomy tube in situ. The isolates of P. multocida were of the same biotype and serotype, and had an identical antibiogram. Epidemiological studies failed to determine the source of these infections.

Aged↗
PubMed1977

Germ tube-positive Candida tropicalis.

The germ tube test is routinely used for the rapid identification of Candida albicans and its variant C. stellatoidea, and is generally thought to be specific for these organisms. Four cases in which yeastlike fungi were isolated, and, although they were germ tube-positive, further morphologic and biochemical examinations identified them as Candida tropicalis are presented.

Aged↗
PubMed1976

Anaplastic neuronal tumors of brain.

A multicentric neuronal tumor of brain with unique morphologic features is described. It is compared with four other markedly anaplastic brain tumors containing neoplastic neurons. Demonstration of axon processes, which must be carefully distinguished from other similarly stained structures, is essential for the recognition of such tumors. Recent experience suggests that anaplastic neuronal tumors are more frequent than is generally realized. It is suggested that axon stains should be more widely employed in the investigation of atypical or highly pleomorphic gliomas.

Adult↗