PubMed Health⌕ Search

Biomedical subjects

M Minz

Publications and source records attributed to M Minz.

64 records · Page 4Linked to original sources
PubMed1979

A study on sleep in amyotrophic lateral sclerosis.

A polygraphic study of sleep has been performed on 12 patients with ALS and 12 normal controls. Neither the total duration of sleep, nor the proportion of different stages of sleep differed significantly between the patient and control groups. A variety of morphologic peculiarities were observed in certain patients: frequent and repetitive blinking movements during the waking state (under quiet, dark conditions); persistence of EMG activity during both PS and SWS; and an early appearance of marked slow delta wave activity at the beginning of sleep. We observed in patients increased PS latency, and longer and more frequent awakenings. Certain patients also showed both qualitative and quantitative abnormalities of respiratory rhythm. A longitudinal study was performed on one patient. Results are discussed in relation to the existing literature.

Aged↗
PubMed1978

Sleep respiratory arrhythmias in control subjects, narcoleptics and non-cataplectic hypersomniacs.

Normal subjects may present central-type apneas or periodic respiration during sleep (stages I and II and paradoxical sleep). The importance of these respiratory disorders increases with age. Hypersomniac patients can manifest either similar or more significant sleep respiratory disorders than normal subjects. The presence of cataplexy or obesity does not permit the prediction of the existence of respiratory arrhythmias or of their type. Sleep respiratory arrhythmias of central type are not likely to cause hypersomnia; however, an aggravating role may be played by obstructive apneas.

Adult↗
PubMed1977

Effect of clonidine on sleep patterns in man.

Clonidine (300 microgram orally) increased in man the total duration of sleep and strikingly reduced the duration of REM sleep. Yohimbine (10 mg per os) did not alter the sleep patterns in man but antagonized the effects of clonidine. These results provide evidence that an alpha sympathomimetic mechanism could suppress REM sleep and increased the total duration of sleep.

Adult↗
PubMed1977

Clinical and polygraphic effects of d.1 5 HTP on narcolepsy-cataplexy.

d.1 5 hydroxy-trytophan (600 mg a day) or a placebo were administered during 4 weeks following a double blind cross over design to 11 narcoleptic-cataplectic patients. Daily number of cataplectic and narcoleptic attacks did not vary. The 36 hours polygraphic recordings performed at the end of each treatment exhibit: a trend toward a decrease of the duration of the day time sleep and a significant increase of the duration of the night sleep.

5-Hydroxytryptophan↗
PubMed1977

[Study of the relation between disorders of nocturnal respiratory rhythm and hypersomnia].

Sleep and respiration were recorded during two consecutive nights in 15 normal subjects, 18 patients suffering from narcolepsy and 9 with non-cataplectic hypersomnia. The normal subjects showed episodes of central apnea, the degree of which increased with age and periodic respiration. In both categories of hypersomniacs, the patients were divided into three groups according to the severity of disturbances in nocturnal respiratory rhythm:--group 1: identical to the normal subjects,--group 2: moderate qualitative or quantitative abnormalities,--group 3: presence of a large number of episodes of obstructive apnea. On the basis of these results, it was concluded that disturbances in nocturnal respiratory rhythm are not specific for any particular type of hypersomnia, nor were they the main cause of hypersomnia when present to a large extent, but that obstructive apnea could be an aggravating factor.

Adult↗
PubMed1976

[Suppression of paradoxal sleep by clonidine in man].

The administration of clonidine (300 mug) suppresses REM sleep or strikingly diminishes its duration in Man. The statistical difference with placebo given in a double blind trial is highly significant. This suppression of REM sleep may depend on the stimulation of alpha-adrenergic receptors.

Adult↗
PubMed1976

Human sleep and 5-HTP. Effects of repeated high doses and of association with benserazide (RO.04.4602).

On account of the conflicting data concerning the action of 5-HTP on human sleep, repeated high doses were administered to three healthy subjects. The paradoxical sleep time and percentage tend to show a decrease during the 2nd week of treatment, followed by a rebound effect after the end of the treatment. In two subjects who initially had a small amount of slow wave sleep (SWS), the treatment induced an increase in SWS that persisted after the end of the treatment. Similar results were obtained after administration of 5-HTP together with RO.04.4602.

5-Hydroxytryptophan↗
PubMedDate not supplied

Fibrosing cholestatic hepatitis-like syndrome in a hepatitis B virus and hepatitis C virus-negative renal transplant recipient: a case report with autopsy findings.

We report a patient with fibrosing cholestatic hepatitis (FCH)-like syndrome in renal transplant recipient, who was negative for hepatitis-B and C-virus infection. The patient presented initially with extrahepatic biliary obstruction due to stricture at the lower end of the common bile duct. Cholestasis persisted inspite of effective biliary drainage. He was operated for empyema of the gallbladder and histological examination showed the presence of cytomegalovirus inclusions in the wall of the gallbladder. The patient died inspite of aggressive management; autopsy examination of the liver revealed evidence of FCH-like changes.

Autopsy↗