[The lipoprotein status in persons with borderline glucose tolerance impairment before and after a reducing diet].
The well known association between non-insulin dependent diabetes mellitus (NIDDM) and hyperlipoproteinemia (HLP) is one of the leading causes of high incidence and mortality for cardiovascular disease of diabetic patients. For auspicious and effective treatment of NIDDM and its complications, secondary prevention, that is, an early detection, plays a major role. At the same time high concern should be given to the benefits of early detection and treatment of atherogenic HLP at early stages of diabetes mellitus, for their occurrence in borderline impairment of glucose tolerance (G-OGT) is still evasive. The investigation on the occurrence and incidence of HLP in G-OGT was carried out in 576 adults (310 men and 266 women) with recently detected G-OGT. The results were compared with those obtained in the non-G-OGT group (50 men and 52 women). Values of total LDL cholesterol as well as triglycerides in the blood of the subjects of either sex highly exceeded recommended values and were higher than in the controls. HDL cholesterol was significantly decreased while the values of the LDL cholesterol/HDL cholesterol ratio and total triglycerides were significantly higher. Atherogenic hyperlipoproteinemia was evidenced in 52.58% of men and 50.75% of women with G-OGT and in 36.00% of men and 32.69% of women with normal G-OGT. After a one-year dietetic regimen all the lipid parameters evidently improved in both men and women, while the incidence of atherogenic hyperlipoproteinemia fell to 40.82% of the men and 31.32% of the women.