Biomedical subjects

M Mizunaga

Publications and source records attributed to M Mizunaga.

26 records · Page 2Linked to original sources

PubMed1989

[A case of ureteral and vesical malacoplakia].

A case of ureteral and vesical malacoplakia is reported. A 58-year-old woman was admitted for non-papillary sessile bladder tumor. Ultrasound examination revealed bilateral hydronephrosis and renal function was deteriorated. Escherichia coli and beta-streptococcus were isolated from her urine. Antegrade pyelography demonstrated obstruction of the bilateral ureters. Percutaneous pyeloscopy revealed a bean-sized yellow nodule at the upper portion of the right ureter. Pathohistological the lesions of aggregates of macrophage in which typical Michaelis-Gutmann bodies were found at the punch biopsies of both vesical and ureteral lesions. She was treated successfully with the administration of bethanechol chloride and antibiotics. This case seems to be the second report of ureteral malacoplakia in the Japanese literature.

Bethanechol↗

PubMed1989

[Ileovesical fistula complicating Crohn's disease: a case report].

A 43-year-old woman was admitted on October 6, 1987 with the chief complaint of fecaluria, pneumaturia and miction pain. She had been diagnosed as Crohn's disease in March, 1987. Urinalysis revealed numerous leucocytes, and streptococcus faecium was identified by urine culture. Contrast film of small intestines showed ileovesical fistula arising from terminal ileum. Cystoscopy revealed a papillary tumor-like appearance at the dome of the bladder. An operation was performed on November 9 under the diagnosis of ileovesical fistula complicating Crohn's disease. It was found that ileal region formed a hard adhesion to the bladder wall. Partial resection of the ileum and bladder was performed. Ileovesical fistula was found in the adhesion. Histological diagnosis of the affected ileum was Crohn's disease, showing noncaseating granuloma with the multinucleated giant cells. This case is the first report of female urological complication of the Crohn's disease in the Japanese literature.

Adult↗

PubMed1989

[A case of primary transitional cell carcinoma of the prostate].

A 58-year-old man was admitted to our hospital with the complaint of pollakisuria and micturitional pain. The urine cytology showed malignant cells suggesting the urothelial cancer, but various examinations could not reveal the malignant lesion. The prostate was also normal by the digital examination, endoscopy, roentgenography, ultrasonography and serum markers, and the transperineal prostate biopsy showed no malignancy. Three years after the first admission the prostate showed slight hardness and the transperineal biopsy suggested adenocarcinoma of the prostate. Hormonal therapy was then started and the prostate showed no remarkable change until about two years later, when rapid progression of the prostatic tumor was recognized. The transperineal biopsy of the prostate revealed the transitional cell carcinoma with negative staining of Alcian-Blue, PAS and PSA (prostate specific antigen). The epithelia of the bladder and posterior urethra were normal. The radical cystoprostatectomy was done and the histological diagnosis was the pure type of primary transitional cell carcinoma of the prostate. The literatures were reviewed and the clinical differentiation between transitional cell carcinoma and adenocarcinoma of the prostate was discussed.

Antineoplastic Combined Chemotherapy Protocols↗

PubMed1987

[Study of levels of latamoxef in prostatic tissue and bladder mucosal tissue].

The concentration of Latamoxef (LMOX) in the serum, prostatic tissue and bladder mucosal tissue of 20 patients with benign prostatic hypertrophy and bladder cancer was measured after intravenous infusion of 1 g or 2 g of LMOX. Serum, prostatic tissue and bladder mucosal tissue levels of LMOX responded satisfactorily to the dose of LMOX. The bladder mucosal tissue level was higher than the prostatic tissue levels. Judging from the inhibitory concentration of LMOX (MIC 80), the concentration was sufficiently effective against infections caused by gram-negative, gram-positive and anaerobic bacilli.

Dose-Response Relationship, Drug↗

PubMed1987

[Clinical study of ofloxacin (OFLX) on urinary tract infections].

Fifty-three patients with urinary tract infections (UTI) were treated with Ofloxacin, a new oral synthetic antimicrobial agent, and its clinical efficacy was studied. Ofloxacin (600 mg/day) was administered to 35 patients with acute simple cystitis for more than three days, and to 17 patients with complicated UTI for more than five days except a case in which the treatment was interrupted for side effects. Acute simple cystitis: In ten cases meeting the criteria of UTI committee, overall effectiveness rate was 100%. All of the 26 strains isolated from 26 patients disappeared after the treatment. In all of acute simple cystitis cases, 94.3% were evaluated as excellent or as moderate by attending doctors. Complicated UTI: In 11 cases treated during five or seven days, 63.6% of patients showed improvement on pyuria. Seven out of nine strains isolated from seven patients disappeared. However, two strains of P. aeruginosa and P. cepacia persisted after the treatment. In all of the complicated UTI cases, 38.9% of patients were evaluated as excellent or as moderate by attending doctors. Some slight side effects were observed in four out of 53 cases. This study showed that Ofloxacin is effective against urinary tract infections.

Acute Disease↗

PubMed1986

[Uroflow metrical analysis of normal adults by male uroflow diagnostic interpretation].

Uroflowmeter has been well documented as an indispensible tool in lower urinary tract diagnosis. In this study 145 normal urinary flow curves in 36 healthy adult males were analysed using the Male Uroflow Diagnostic Interpretation (MUDI) of the DISA urological investigation system. In MUDI, the flow rate pattern is analysed and quantified by previously defined parameters. Then the computed values of these parameters are compared with the values observed in healthy subjects. Finally, the results are conveniently presented on an output sheet. One of the newly defined parameters, (dL/dT) 40, i.e., the bladder contraction velocity at 40 ml before the end of micturition, was situated within the range of 12.5 to 28.3 mm/sec (20.4 +/- 3.9 mm/sec) in healthy males. The variable (dL/dT) 40 did not depend on voided volume and provided excellent discrimination between the control group of healthy males and the group of patients with dysuria. MUDI improves the faults of previous uroflowmetry systems and provides (dL/dT) 40 by which micturition patterns can be discriminated to be good and bad ones. So MUDI seems to be quite versatile in daily urological clinics.

Adult↗

PubMed1985

[Transfer of ceftizoxime into serum and prostatic tissue].

Serum and prostatic tissue levels of Ceftizoxime (CZX) were measured in 37 patients with benign prostatic hypertrophy after intravenous infusion of 0.5 g or 1 g or 2 g of CZX. The prostatic tissue level of CZX was sufficient for the treatment of prostatic infection. Serum and prostatic tissue levels of CZX were maintained satisfactorily by the dose of CZX. Neither the weight of extracted prostatic tissue nor the renal function of the patient was correlated to the tissue level of CZX.

Cefotaxime↗

PubMed1985

[The use of dimethyl sulfoxide in the treatment of intractable urinary frequency].

Intravesical instillation of dimethyl sulfoxide (DMSO) was used in the treatment of patients with intractable urinary frequency due to chronic prostatitis, chronic cystitis, tuberculous contracted bladder and interstitial cystitis. Before the application of this therapy, all 4 patients were examined carefully to rule out cases of acute infectious diseases of the urinary tract, active urinary tuberculosis, neurogenic bladder and carcinoma in situ of the bladder. Three of the four patients achieved an excellent response both subjectively and objectively. In the United States, intravesical instillation of DMSO had already been established as the specific method in the treatment of interstitial cystitis and no side effects have been reported so far. Therefore, we recommend the use of intravesical instillation of DMSO more commonly in various forms of intractable urinary frequency.

Adult↗