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Biomedical subjects

M Mladenov

Publications and source records attributed to M Mladenov.

10 recordsLinked to original sources
PubMed1997

[The metastasis of prostatic cancer and the methods for its demonstration].

Metastasizing of prostate gland carcinoma is an essential and characteristic feature of its biological manifestation. The high capacity of prostate tumor cells to spread via lymphatic and blood stream explain the development of metastases in 52 to 80 per cent of patients presenting for primary diagnosis. Metastatic lesions are usually located in the lymph nodes (24.12 per cent), spinal cord (50.37 per cent), pelvis (56.27 per cent) and femur (2.09 per cent). It is impressive that according to personal experience and pertinent literature data, lymph and bone localizations vary in a wide range--29 to 66 per cent--thereby necessitating to resort to all well known diagnostic methods for demonstrating the presence of both contact and distant metastases.

Adult↗
PubMed1984

[Streptococci and staphylococci in raw cow's milk on the market].

Studied were a total of 649 batches of raw cow milk produced on 42 farms, and 1100 flushing samples taken from 370 containers for the presence of pathogenic streptococci and staphylococci. It was found that 26.5 per cent, resp., 18.03 per cent of the batches contained coagulase-positive staphylococci and pathogenic streptococci (in 8.94 per cent--Str. agalactiae, in 6.0 per cent--Str. uberis, and in 3.08 per cent--Str. dysgalactiae ). In 28.3 per cent of the batches there were both strepto - and staphylococci that had pathogenic character. The study of the flushing material showed that the cleaning of containers for shipping the milk from the farms to the dairy processing enterprises was effective--only 1.62 per cent of the cisterns were contaminated with pathogenic strepto - and staphylococci.

Animals↗
PubMed1981

[Etiological study of mastitis in cows].

The rapid mastitis test was employed to study a total of 13 880 cows on 40 farms. Positive for mastitis proved 2384 udder quarters. Clinically manifested mastitis was established in 3.23 per cent of the cases, subclinical mastitis - in 58.14 per cent, carrier status - in 12.55 per cent, secretion disturbances - in 22.58 per cent, and normal proved 3.84 per cent. In the mastitis-positive cases pathogenic streptococci were isolated in 57.14 per cent of the quarters, staphylococci - in 20.77 per cent, Corynebacteria - in 9.09 per cent, and other bacteria - in 5.19 per cent. In the cases with subclinical mastitis staphylococci accounted for 40.93 per cent, streptococci - for 38.7 per cent, Corynebacteria - for 14.22 per cent, and other organisms - for 6.0 per cent. Most frequently encountered were the carriers of staphylococci - 46.8 per cent, followed by those of Corynebacteria - 26.4 per cent, and of streptococci - 20.73 per cent.

Animals↗
PubMed1981

[Enterococcal studies of uncut raw dried meat products].

Studies were carried out on a total of 75 samples of raw-dried meat products of a compact type--dried beef, Gabrovska Keiser dried meat, pig salted neck, rolled meat Trapezitsa, V. Turnovo delicacy, and Elena fillet, to establish the amount of Staphylococcus bacteria. It was found that the enterococcus titer of this type of meat products varied from 10(-1) to 10(-4), depending on the product. Most strongly contaminated with enterococci proved the pig salted neck. The higher amounts of enterococci in the studied products as well as their higher resistance to the action of unfavourable factors (ph, NaCl, water content) showed their advantage over the coliform bacteria as sanitary-index organisms in raw-dried meat products of a compact type. Various ratios of all species of enterococci were established in these products. Str. faecius was most often found (32.44 per cent), followed by Str. faecalis (26.22 per cent), Str. faecalis var. liquefaciens (16.00 per cent), and Str. durans (12.00 per cent). Str. faecalis var. zymogenes (8.00 per cent) and Str. bovis (5.33 per cent) were isolated less frequently from some of the products only.

Animals↗
PubMed1981

[Physical methods (ultrasound) and disinfecting agents for decontaminating the water in poultry meat processing].

Productional and laboratory experiments were carried out to study the effect of ultra sound with a view to decontaminating the water in the vats for cooling poultry carcasses and skin cover as well as that of disinfection means (inkosan, actofor, yomil S, chalamide, and chloramin). In vitro studies revealed that the use of ultra sound in the decontamination of cooling water and poultry meat surface did not produce the necessary effect. The iodofor preparations inkosan and yomil S as well as the agents chalamide and chloramine added in fixed concentrations to the water in cooling vats were not shown to be able to inactivate Salmonella organisms on the surface of experimentally contaminated poultry carcasses. Inkosan at the rate of 1:1000, and yomil S at 0.2 and 0.4 per cent produced a 100 per cent bactericidal effect against the microflora in vat waters regardless of their initial contamination. Except for yomil S at 0.4 per cent these agents did not affect the organoleptic properties of poultry meat.

Animals↗
PubMed1980

[Staphylococci in uncut raw dried meat products].

Studied were a total of 75 samples of raw-dried meat products in a compact form (dried beef, Gabrovska Keiser dried meat, pig salted neck, Trapezitsa rolled meat, Veliko Turnovo delicacy, and Elena fillet) produced at 11 Meat Works for the presence of staphylococci. It was found that the Staphylococcus titre in such raw-dried meat products was within the range of 10(-3) to 10(-7). Veliko Turnovo, Gabrovska, and Trapezitsa products were shown to be most contaminated. Coagulase-positive staphylococci were demonstrated in as much as 0.1 g of them--in the case of Elena fillet all samples were positive, with dried beef--10 samples, with Trapezitsa--7 samples, with Gabrovska--4 samples, and with pig salted neck 2 samples. The isolated strains of coagulase-positive staphylococci (48) were chiefly of bovine origin, and were typed by means of a mixed phage set comprising phages of groups II, III, and IV. The most commonly established phage types were 53/6/42D77 and 42D/102/107/117/119/77/42E. The compact raw-dried meat products were shown to contain all species of staphylococci. Staphylococcus epidermidis was most often isolated (with the exception of Elena fillet).

Animals↗