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Biomedical subjects

M Mobayed

Publications and source records attributed to M Mobayed.

7 recordsLinked to original sources
PubMed1992

Treatment resistance of depression after head injury: a preliminary study of amitriptyline response.

Thirteen patients with depression following minor head injury were matched with 13 functional depressives. Both groups were indistinguishable psychopathologically. Five of the functional group had a family history of affective disorder and none of the head-injury group had such a history. Both groups were treated with amitriptyline, beginning with 100 mg daily, increasing to a maximum of 250 mg/d. There were significant differences in response between the 2 groups, with only 4 of the head-injury patients improving. Our preliminary results suggest that this condition is relatively resistant to tricyclic therapy.

Adult↗
PubMed1990

A pilot study of a neuroendocrine test battery in posttraumatic stress disorder.

Eight female patients who fulfilled DSM-III criteria for posttraumatic stress disorder (PTSD) took part in this study. They were each assessed using the dexamethasone suppression test, the desipramine/growth hormone stimulation test, which examines alpha-2-adrenoceptor functioning, and the buspirone/prolactin test, which is thought to examine 5-HT receptor functioning. A control group consisting of age- and sex-matched healthy subjects was also tested. For each subject the three tests were conducted over 5 days. Hormone assays were carried out blind to diagnosis. Overall no differences on any of the three tests were detected between the patients and controls. The results do not support a link between PTSD and major depression.

Adult↗
PubMed1990

Buspirone/prolactin response in post head injury depression.

Fifty-five male patients who had suffered a mild head injury 11-13 months previously were investigated for evidence of depression. Eleven were diagnosed as DSM-III major depressives, nine with melancholia. Prolactin response to buspirone was examined in these patients, in eight male head-injured patients without depression and 10 age-matched male healthy controls. The prolactin response was significantly blunted in post head injury depressed patients compared to head injury non-depressed and healthy control groups. We suggest that these differences may be due to altered serotonin functioning post head injury.

Adult↗
PubMed1990

The reproducibility of the prolactin response to buspirone: relationship to the menstrual cycle.

Prolactin response to buspirone challenge was examined in eight normal healthy male and six healthy female volunteers. A significant increase in prolactin levels was noted around 90 min following oral administration of buspirone hydrochloride. When subjects were tested on two further occasions it was found that responses in males were consistently reproducible while responses in females varied throughout the menstrual cycle with maximum responses occurring premenstrually. It is postulated that increased sensitivity of the 5HT receptor premenstrually may explain the variability in females.

Adult↗