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Biomedical subjects

M Mohan

Publications and source records attributed to M Mohan.

231 records · Page 13Linked to original sources
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Modulation of vagus escape phenomenon by afferent vagal stimulation.

The present study was conducted on healthy adult mongrel dogs under chloralose urethane anaesthesia. After bilateral midcervical vagotomy, peripheral end of either vagus was stimulated continuously. This stimulation produced cardiac asystole followed by escape beats. Initially, the heart rate and arterial pressure were low, but both increased progressively and reached a steady-state level in 1-3 min while stimulation of peripheral vagus continued. During this plateau of vagus escape, stimulation of the central end of either vagus produced elevation of arterial pressure and cardio-acceleration. This modulation of vagus escape phenomenon by afferent vagal stimulation was reproducible.

Animals↗
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Reaction time in clinical diabetes mellitus.

Visual and auditory reaction times were studied in patients suffering from diabetes mellitus and age matched normal control subjects. Auditory reaction times were shorter than visual reaction times in control subjects as well as diabetic patients. In diabetic patients, there was significant prolongation of visual as well as auditory reaction times. Further studies of reaction times for various modalities may provide a better insight into the neurological disturbances in diabetes mellitus.

Adult↗
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Therapy of myopia.

Explore the source record for details and available documents.

Animals↗
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Effect of cowdung smoke inhalation on E.C.G. of rats.

The present study was conducted on 20 adult albino rats divided into group I (n = 10) and group II (n = 10). Group I animals were exposed to cowdung smoke for 60 min twice a day for a period of 75 days whereas group II served as control. ECG of control rats was essentially similar to that of man. ST segment was absent, Q wave absent or rudimentary and the mean QRS axis + 45 degrees. Rats exposed to cowdung smoke revealed a significant increase in PR interval and a mean QRS of + 117.5 degrees. Our results indicate that inhalation of cowdung smoke leads to conduction defects and right axis deviation.

Animals↗
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Electrocardiographic changes in experimental drowning.

Healthy mongrel dogs were subjected to aspiration of 20 ml/kg of fresh water (group I) or sea water (group II). Fresh water as well as sea water aspiration produced an immediate and significant bradycardia and the heart rate remained appreciably low throughout the forty minute study period. Appearance of tall T waves was the chief electro-cardiographic abnormality seen in both the groups. Out of seven dogs subjected to fresh water aspiration, two died of ventricular fibrillation and the other five survived. On the other hand, out of seven dogs subjected to sea water aspiration, five died of ventricular asystole within 10 min. This shows that equivalent volume of sea water is more lethal than fresh water. Further it is concluded that ventricular fibrillation is common after fresh water aspiration whereas sea water aspiration commonly leads to ventricular asystole.

Animals↗
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Cardiovascular effects of acetaldehyde in guinea pigs.

The hemodynamic effects of intravenous administration of acetaldehyde were determined in anesthetized control (group I), propranolol pretreated (group II) and phentolamine pretreated (group III) guinea pigs. Acetaldehyde produced an immediate and significant increase in mean arterial pressure followed by its progressive decrease resulting in hypotension. Heart rate increased significantly. In propranolol treated animals, acetaldehyde-induced tachycardia was not produced whereas in phentolamine treated animals, the initial pressor response was converted into a depressor one. Hence the increase in mean arterial pressure and heart rate produced by acetaldehyde are likely to be due to catecholamine release from adrenergic nerve endings.

Acetaldehyde↗
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Effects of aspirated and swallowed water in mongrel dogs subjected to fresh-water drowning.

The effects of aspiration or aspiration-cum-swallowing were studied in two groups of anesthetized dogs. Group I animals were subjected to aspiration (20 mlg/kg) whereas that of group II to aspiration (20 ml/kg) cum-swallowing (20 ml/kg) of fresh water. Aspiration produced decrease in plasma sodium and chloride whereas potassium, hemoglobin and haematocrit increased. These changes were transient and the values came back towards preaspiration level in the surviving animals. In animals subjected to aspiration-cum-swallowing, there was no initial increase in hemoglobin and hematocrit and both these values decreased significantly. The pattern of electrolyte changes was essentially similar to the aspiration group. All the animals in the two groups showed an immediate onset of significant asphyxia and acidosis that persisted throughout the period of observation. It is concluded that aspiration of 20 ml of fresh water per kg body weight produces only transient changes in hemoglobin, hematocrit and electrolyte balance, whereas the changes in arterial gas and pH are significant and persistent. It is further concluded that the swallowed water modifies the aspiration induced changes in fresh water drowning.

Animals↗