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Biomedical subjects

M Molaschi

Publications and source records attributed to M Molaschi.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Relations between markers and immunological status in surgical patients. Tumor markers and immunity in surgery].

The correlation between the immunological status of surgical patients and cancer is examined. 52 patients with gastric and colonic cancer were studied. On the basis of the immunological results of skin tests these were subdivided into non-reactive and reactive. The two groups were statistically compared in relation to cancer stage and blood concentrations of 4 markers: CEA, Ca 19-9, Ca-50, T.A.T.I. The first data show that anergic patients are older to a statistically significant degree; the second that there are no significant differences between the two groups as regards cancer stage. The third data show a difference between the two groups in relation to two of the four markers; anergic patients have a statistically significant higher blood concentration of CEA and T.A.T.I. This is rather interesting, since the literature offers no specific studies on the correlation between the patient's immunological status and tumour marker concentration. Therefore, in clinical practice, the high concentrations of these markers, could reveal, as well as the presence of cancer an endangered immunologic status.

Adenocarcinoma↗
PubMed1987

Functional vascular disorders: treatment with pentoxifylline.

A group of 11 female patients (mean age 33.7 +/- 8 years) with a clearly proven primary Raynaud's syndrome of up to five years' duration were subjected to a two-month oral treatment with 3 X 400 mg pentoxifylline per day. The following parameters were studied without and with exposure to cold conditions: hemodynamics (finger photoplethysmography), red cell deformability (filtration test), various clotting variables (prothrombin activity, antithrombin III, plasma fibrinogen, partial thromboplastin time, thrombin time, thrombelastogram), and clinical symptomatology. After treatment 7 of the 11 patients showed a distinct improvement of peripheral blood flow and of symptoms (decrease or removal of asphyxia attacks, pain, color change) under basal conditions, as well as after exposure to cold. Red cell filtration was significantly (p less than 0.05) improved, increasing by 35% under normal conditions and by 30% after exposure to cold. Positive changes were also found in respect to antithrombin III (increase) and plasma fibrinogen (decrease). The thrombelastogram was unchanged. Clinical and instrumental improvements were probably ascribable to better microcirculatory flow due to increased red cell deformability, reduced viscosity, and decreased fibrinogen, all capable of influencing in various degrees the blood flow at the microcirculatory level.

Adult↗
PubMed1985

[Hemorheological, hemocoagulation and photoplethysmographic changes induced by the administration of pentoxifylline in patients with Raynaud's disease].

1200 mg/day per os of Pentoxyphyllin administered for 60 day brought about an improvement in symptomatology and photoplethysmographic readouts under base conditions and following the cooling test in 7 out of 11 females suffering from Raynaud's disease. These results may be explained by an improved microcirculation flow resulting from increased erythrocyte filterability and a decrease in fibrinogenemia .

Adult↗
PubMed1985

[Strain gauge plethysmography of venous circulation in aged patients with deep vein thrombosis and post-phlebitis syndrome].

Deep-seated venous thrombosis (DVT) is more common in subjects over 40 and is most frequently found in subjects between 60 and 70 years of age. It is thought that the complaint is brought about by paraphysiological factors connected with aging or conditions frequently encountered in the elderly which are interconnected to varying extents. The flow parameters of 30 female subjects with diagnosed DVT, of which 18 were over 60, and 24 female subjects with a phlebographic diagnosis of Post-phlebocytic syndrome (PPS), of which 14 were over 60, were evaluated using the plethysmographic strain gauge technique. Women over 60 with DVT have longer maximum emptying times and higher venous pressures. For this group, maximum emptying time is slightly lower (although not by a statistically significant amount) than for the younger group. Subjects of advanced age with DVT display significantly higher levels of venous obstruction and patients with PPS display higher levels of venous ectasia. These effects are probably caused by venous circulation miopragia due to aging.

Aged↗
PubMed1981

[ADP-induced platelet aggregation in vascular diseases of the elderly].

A study of 60 over-65's, of whom 30 were suffering from coronary disease 15 had previous but now stable cerebrovascular insufficiency and 15 were suffering from circulation insufficiency in the lower extremities, showed that ADP-induced platelet aggregability was significantly increased by comparison with a group of 15 subjects of similar age rigidly selected as "normal". The aggregation rate was more enhanced than other parameters. In patients with coronary insufficiency and in those with cerebral vasculopathy, other aggregability parameters were significantly changed (minimum aggregating concentration). It is concluded that platelet aggregation, which is often increased in physiological ageing, is altered to an even greater extent in the vasculopathic elderly.

Adenosine Diphosphate↗
PubMed1980

[Determination of immunoglobulins in the aged. Normal range and changes in pathological conditions].

Serum IgA, IgG and IgM values in 238 normal aged subjects were compared with those in 100 normal adults. Both male and female aged subjects displayed a significant rise in IgA and a significant fall in IgM, whereas IgG values were not markedly different. It was found that IgA increased and IgM decrease by an average of 12 mg % and 10 mg % (17 mg % in the aged) per decade respectively. Values were also determines in 597 aged hospital patients and related to the disease for which they were admitted. Increases in all three Igs were noted in sclerotic cardiopathy, chronic cerebrovascular insufficiency, acute broncopneumopathy (IgA increase only in chronic forms), and gastroduodenal ulcer. Diverticulosis of the colon and acute pancreatitis, however, were accompanied by elevated IgA values only. Increases were particularly marked in chronic liver disease, less so in diseases of the gallbladder. Neoplasia was usually accompanied by higher Ig levels.

Age Factors↗