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Biomedical subjects

M Monteleone

Publications and source records attributed to M Monteleone.

At least 37 records · Page 2Linked to original sources
PubMed1986

Characteristics of psychiatric patients who engage in assaultive or other fear-inducing behaviors.

The hospital records of 1687 psychiatric patients were rated for the presence of assaultive or other fear-inducing behaviors associated with the reasons for their hospital admissions. Data analyses indicated that significant associations existed between these behaviors and sex, race/ethnicity, diagnosis, previous admissions, referral source for hospitalization, legal status at admission, and legal status at discharge. No associations were found for age, education, marital status, employment status, number of days hospitalized during the index hospitalization, and referral at discharge. A comparison of these results with the results of studies by other investigators led to the conclusion that clinical variables appear to have a more consistent relation to violent behavior than demographic variables. Future research examining for the correlates of violent behavior in psychiatric patients may be more productive by focusing on the type and degree of patients' psychopathologies rather than on patients' demographic characteristics.

Adolescent↗
PubMed1985

Reversed-phase high-performance liquid chromatography of human haemoglobin chains.

A reversed-phase high-performance liquid chromatographic method for the separation of human haemoglobin chains has been devised. Using a LiChrospher 100 CH-8/2 column and a ternary eluent (acetonitrile-methanol-0.155 M NaCl, pH 2.7) improved resolution was achieved between (delta beta) Lepore, beta A, beta S, alpha, G gamma and A gamma chains within a 60-min linear gradient. The A gamma T chain can also be separated by increasing the gradient time and decreasing the flow-rate. Silanophilic interactions play an important role in the retention mechanism, and NaCl addition was necessary in order to suppress adsorption on free silanols. Increasing the methanol concentration to 10% caused a slight increase in chain retention, probably owing to solvation of the stationary phase. The recovery was 82% and the reproducibility of retention times was as good as +/- 1.5%. Quantitation of chains is likely to be possible by peak area measurement. Owing to its sensitivity, the proposed method may be useful in the diagnosis of haemoglobinopathies and in the study of haemoglobin variants.

Chromatography, High Pressure Liquid↗
PubMed1985

The extensor digitorum brevis muscle island flap for soft-tissue loss around the ankle.

The extensor digitorum brevis muscle flap, which has already been suggested as a local flap for the foot, has been applied by us in 2 cases with excellent results. This flap, as with other muscle flaps, provides an excellent bed for the skin graft. Furthermore, because of its width, it allows for covering an area of skin loss 5 X 7 cm in size in areas that are difficult to cover by other reconstructive means. The arch of rotation of this flap allows for coverage of the lateromedial and posterior surfaces of the ankle with no functional loss at the donor site. The relative ease of elevating this flap presents a reasonable justification for its wider application as a single local procedure for skin problems around the ankle.

Adult↗
PubMed1985

Violent or fear-inducing behavior associated with hospital admission.

Recent studies indicate that the incidence of violent or fear-inducing behavior among the mentally ill may be higher than once thought. In this study, medical record admission notes for 1,687 psychiatric patients over a four-year period were examined for indications that the patients had engaged in violent or fear-inducing behavior just prior to hospital admission. This and other studies suggest that the frequency of violent or fear-inducing behavior associated with psychiatric admissions may have stabilized in recent years. The authors also found a significantly higher level of hospital readmissions for violent patients than for other patients. As a result, they caution against assuming that the rate of violent behavior among hospital admissions accurately reflects the prevalence of violent behavior among the general population of the mentally ill.

California↗
PubMedDate not supplied

Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects.

The single dose pharmacokinetics of flutoprazepam and its active N-desalkyl metabolite were determined in 8 normal subjects by using newly developed, highly sensitive, GC-MS and HPLC techniques. Following a 2 mg dose of the drug, the concentrations of unchanged flutoprazepam in serum were extremely low (below 5 ng/ml at 2 h) and declined rapidly to undetectable levels within 6-9 h after dosing. At all sampling times, the serum concentration of the N-dealkylated metabolite (N-desalkylflurazepam) was much greater than that of the parent compound. This metabolite appeared in serum rapidly (within 2 h), reached a peak between 2 and 12 h and declined slowly, with an elimination half-life of about 90 h on average. The serum concentration of two additional putative metabolites (3-hydroxy-flutoprazepam and N-desalkyl-3-hydroxy-flutoprazepam) was below the limit of detection (2 ng/ml) in all samples. Mild CNS effects (documented by prolonged choice reaction time) were present at 2 and 4 h but were no longer detectable at 9 h. It is suggested that unchanged flutoprazepam is unlikely to contribute significantly to clinical effects and that the drug exerts its therapeutic activity through conversion to the slowly eliminated N-desalkyl metabolite.

Administration, Oral↗
PubMedDate not supplied

Giant cell tumor of the hamate bone.

The authors present two cases of giant cell tumor of the hamate bone. The symptoms and signs were similar in both cases: pain, mild inflammatory changes, and localized swelling. The radiographic picture included lacunar osteolysis with interruption of the cortex in one case, intact cortex but more expansive lysis of the cancellous bone in the other. The findings of greatest interest were constituted by the extreme rareness of the localization, problems related to differential diagnosis, long-term follow-up in one case (20 years) and the different methods of treatment used.

Adult↗