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Biomedical subjects

M Moretó

Publications and source records attributed to M Moretó.

65 records · Page 4Linked to original sources
PubMed1981

Galactose and leucine transport in the developing rat small intestine.

Jejunal transport of galactose and leucine was studied in 9--45 day-old rats by means of the everted sac technique. Maximum transport was observed in 9--10-day-old rats, but then decreased until the 22nd day, and remained unchanged from then on. There were no remarkable differences in the pattern of galactose and leucine transport over this period.

Animals↗
PubMed1980

The laparoscopic diagnosis of the liver fascioliasis.

The laparoscopic findings in 18 cases of liver fascioliasis are described. The characteristic lesions are white and yellow cords on the liver surface that delineate the necrotic tunneliform areas created by the parasite as it penetrates the hepatic tissue. The peritoneum adjacent to the liver also is frequently involved. There was ascites in the 22.2% of the cases. Guided laparoscopic biopsy of peritoneal nodules and of visible liver lesions yielded significant findings more often that percutaneous liver biopsy alone.

Biopsy↗
PubMed1980

Effect of glipentide on galactose absorption and disaccharidase activity in rat small intestine.

The effect of hypoglycemic sulfonylurea glipentide on galactose transport and disaccharidase activity has been studied in rat small intestine. When 2 x 10(-4) M glipentide is present in the mucosal bathing solution, galactose active transport is inhibited 30% both in vivo and in vitro. Treatment of rats with 5 mg/kg glipentide p.o. for 10 days does not modify galactose absorption of disaccharidase activity. Incubation of the enzymes with glipentide shows no direct effect of the drug on its hydrolytic activity. The effects of glipentide on sugar transport are slight, or non significant in maintaining low blood sugar levels.

Animals↗
PubMed1979

Effect of ethanol on glucose and tyrosine transport in the rat small intestine.

The effect of ethanol on the intestinal absorption of glucose and tyrosine in the rat small intestine has been studied. Ethanol inhibits the active transport of these substrates both in incubation and preincubation experiments. Ethanol, besides, increases diffusion of arabinose, which may indicate an unspecific alteration of intestinal permeability.

Animals↗
PubMed1979

Oxyphenisatin derivatives and intestinal glucose and tyrosine absorption.

The effect of oxyphenisatin and three other isatin derivatives on glucose and tyrosine absorption is studied in rat small intestine, in vitro. Compounds with free phenolic groups elicit, even at low concentrations, strong inhibition on active transport, while those with the sulfate-esterified phenolic groups show no effect whatsoever. One minute preincubation with 10(-7) M oxyphenisatin is enough to inhibit sugar absorption completely.

Glucose↗
PubMed1979

3,3-Bis-(4-hydroxyphenyl)-7-methyl-2-indolinone (BHMI), the active metabolite of the laxative sulisatin.

The disodium salt of the sulphuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone (sodium sulisatin, Laxitex), a synthetic laxative with two phenolic groups esterified with sulfate, has been studied in order to find out if its laxative properties may be attributed to the unaltered compound or to its diphenolic derivative BHMI. We first studied the effect of homogenates of the gastrointestinal tract of rats and of rat cecal content of the hydrolysis of sulfate ester bonds of sulisatin. Results show that sulisatin can be hydrolyzed by cecal content while homogenates of stomach, small intestine and large intestine have no hydrolytic effect. Sulisatin is also a substrate of arylsulfate sulphohydrolase obtained from the snail Helix pomatia. The unaltered drug has no effect on the intestinal motility since it does not change the intestinal transit speed in rats pretreated with neomycin sulfate. Sulisatin (1.5, 3 and 6 mg) is unable to inhibit water absorption in rat colon while small amounts of BHMI (15 and 30 micrograms) may inhibit it significantly. It is concluded that sulisatin passes unaltered through the small intestine and is hydrolyzed in the large intestine by the intestinal microflora to its diphenolic derivative BHMI, which is responsible for the laxative activity of the drug.

Animals↗
PubMed1976

Study of the laxative properties of the disodium salt of the sulfuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone (DAN-603 in the rat.

The influence of DAN-603 (disodium salt of sulphuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone) on the propulsive motility of the rat digestive tract was studied by means of indicators (charcoal and pyrvinium pamoate) and radioactive tracers (133BaSO4). The results showed that DAN-603 increases selectively the colon motility without modifying the speed of gastric, intestinal (small intestine) and caecal emptying.

Animals↗