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Biomedical subjects

M Moretti

Publications and source records attributed to M Moretti.

At least 73 records · Page 4Linked to original sources
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Low-dose "natural" alpha-interferon in B-cell derived chronic lymphocytic leukemia.

BACKGROUND: Alpha-interferon (alpha-IFN) was found to have a good antiproliferative effect in early stage chronic lymphocytic leukemia (CLL), but recombinant alpha-IFN administration may induce serious side effects. Therefore low-dose "natural" IFN was evaluated in terms of efficacy and safety. METHODS: Fifteen patients affected by stage A (according to Binet) B-CLL underwent the treatment: natural IFN 1 MU three times a week for 6 months. RESULTS: Overall lymphocyte count decreased from 13,050 +/- 3,200 to 7,500 +/- 2,940 within 6 months. One patient did not respond to IFN therapy. No one complained of side effects. CONCLUSION: Low dose "natural" alpha-IFN seems useful and well tolerated in CLL, but the potential curative role of IFN in CLL remains to be established.

Aged↗
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[Problems of development and care of children born with selected congenital malformations: Down's syndrome, cardiopathy, cleft lip and palate, clubfoot].

In connection with the surveillance programme of congenital malformations in Emilia Romagna led by I.M.E.R. Group since 1978 a crosswise survey has been performed on selected malformations: Down's syndrome, cardiac defects, unilateral or bilateral cleft lip and/or palate, unilateral or bilateral club foot. This survey has been useful as a pilot-study for another longitudinal survey which had a place in the programmes of the C.N.R. (National Research Council). By means of a multi-discipline approach we have collected information both of pediatric and of psycho-social character. A total of 187 children with the above named malformations were recorded at birth, 106 boys and 81 girls, aged from 9 months to 4 years. The neonatal diagnosis was confirmed in 84 out 86 cases under study. The rate of infant mortality was particularly high among children with heart defects (39.1%) and Down children (27.4%). The surgical centres where these children were operated upon, through with large variations in connection with the type of malformation, were in Emilia Romagna (49%), outside it (40%), and abroad (10.9%). As for the parental reaction to the birth of babies with congenital malformations, it was of initial rejection 5 cases of Down children, 3 cases of cardiopathy and 1 case of cleft lip and palate. Later the refusal was permanently confirmed only in 2 cases of Down children (who were subsequently adopted). The birth of a malformed baby has affected the relationship between husband and wife contributing to the separation in 3 cases of Down's syndrome and in 1 case of cardiopathy.

Child↗
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[Genito-urinary malformations in a regional survey in Emilia Romagna].

In a multicentric survey carried out in Emilia Romagna area on congenital malformations 1914 babies out of 103484 babies born from 1978-1984 were discovered to have malformations. Out of these malformations cases 17% were found to be affected by genitourinary tract anomalies (GU) divided as follows: 235 genital malformations and 91 urinary tract anomalies. All these GU patients were diagnosed within the first week of life. Genital malformations: Genital malformations are mainly constituted by hypospadias, found in 214 out of 235 babies. Among these babies, 72% have first degree hypospadias, 22.4% have second degree, and only ten babies were found with third degree hypospadias. In this study 4.1 out of 1000 male newborns have been found affected by hypospadias, in agreement with the results of other researches whose values were between 2% and 4.4%. Many different variables (such as parental age, exposure to smoke, alcohol, RX-ray before pregnancy, low birth weight, early age at menarche, exposure to progestins for threatened abortion, shorter gestation) have been considered in order to verify their correlation with the hypospadias, comparing with control group. Among these the most statistically significant are the exposure to progestins for threatened abortion (p less than 0.05), early age at menarche (p less than 0.001) and the intrauterine growth retardation (p less than 0.001). Also these results agree with the previous studies. Urinary tract anomalies: the 93 babies with kidney and-or urinary tract malformations out of 103484 newborns represent the 8.9%. The diagnoses were made or suspected (and later confirmed) during the first week of life.(ABSTRACT TRUNCATED AT 250 WORDS)

Female↗