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Biomedical subjects

M Mornet

Publications and source records attributed to M Mornet.

13 recordsLinked to original sources
PubMed1994

Subcutaneous heparin treatment increases survival in small cell lung cancer. "Petites Cellules" Group.

BACKGROUND: A positive influence of anticoagulant treatment in small cell lung cancer (SCLC) has been suggested by experimental and clinical data. METHODS: In a multicenter clinical trial, 277 patients with SCLC were randomized either to receive or not to receive subcutaneous heparin injections for 5 weeks at effective doses, which were monitored by blood coagulation tests. All patients received one of the two chemotherapy regimens studied in this trial, for eight courses in the case of patients with complete or partial response, and subsequently were randomized to receive delayed thoracic radiotherapy after these eight courses. RESULTS: In comparison to the 139 patients who did not receive heparin, the 138 patients who received anticoagulant treatment obtained better complete response rates (37% vs. 23%, P = 0.004), better median survival (317 days vs. 261 days, P = 0.01), and better survival rates at 1, 2, and 3 years (40% vs. 30%, 11% vs. 9% and 9% vs. 6%, respectively). At subgroups analysis, the results on survival were obtained for limited forms (P = 0.03) but not for extensive diseases (P = 0.31). No important bleeding or thrombocytopenia was related to heparin treatment. CONCLUSIONS: These results confirm the value of anticoagulant treatment in SCLC, already suspected for warfarin and now proven for heparin, but the modes of administration and the biologic explanations for this activity still warrant further investigation.

Aged↗
PubMed1994

[Ureteral stenosis caused by pelvic actinomycosis].

The authors report a case of pelvic actinomycosis causing ureteral obstruction in a 30-year-old woman. An intra-uterine device being in place for 6 years is considered as the main cause. The treatment, which included a laparotomy for abscess drainage, an indwelling double pigtail ureteral stent and a 9 month antibiotherapy led to recovery after an initial relapse.

Actinomycosis↗
PubMed1986

[Orf: recontamination 8 months after the original infection. Review of the literature apropos of a case].

Frequent in France among domesticated sheep and goats, contagious pustular dermatitis of the sheep is called Orf when it occurs in man. The authors present a case of recontamination in a woman farmer of the Cher department (Central France), who had been bottle-feeding lambs affected with the zoonosis. This 71-year old woman developed papules, then papulopustules on the ulnar aspect of her hands and wrists (fig. 1). Within a few days, these lesions were 1.5 to 2 cm in diameter and surrounded with a severe inflammatory reaction. Two weeks later, the pustules became encrusted. Electron microscopy of a fragment of lesion demonstrated the virus. Cure was observed after 3 weeks. Eight months later, however, lesions identical with the previous ones appeared on the 4th finger and on the median aspect of the right wrist, corresponding to excoriations caused by nibbling from the lambs. The eruption was accompanied with fever which persisted for one month. In this patient's farm, the disease was present for the first time and affected only 2-month old lambs in the form of numerous papulo-pustules located on the lips and later covered by hard and thick scabs. These lesions were also found on the tongue and palate of some animals (fig. 5), preventing them from taking any food. Vaccination resulted in rapid and dramatic regression of the enzootie. From a more general point of view, the clinical features and epidemiology of the disease are described comparatively in animals and man. The differential diagnosis is dealt with at the end of the article. The literature on the subject is reviewed (151 references).

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PubMedDate not supplied

[Malignant fibrous histiocytoma of soft tissue: atypical presentations. Value of combined surgery and chemotherapy].

The authors report five cases of malignant fibrous histiocytoma of the soft tissues, some of them with atypical presentation (necrotizing tumor, hypereosinophilic syndrome, dermatomyositis). This is the first case of polymyositis associated with malignant fibrous histiocytoma. The tumor occurs between the fifth and the seventh decade, principally as a mass on the proximal lower limb. Local recurrence and metastasis occurs in 50% of patients. Prognosis is dependent on both the surgical possibilities and the characteristics of the tumor (site, size, histologic grade). Surgery alone is inadequate. Adjuvant chemotherapy improves the 5-year survival.

Adult↗
PubMedDate not supplied

[Doxapram in stable obstructive chronic respiratory insufficiency. A prospective study on 15 cases (author's transl)].

The oral form of Doxapram, a respiratory analeptic drug with central action, was tested prospectively and successively, the subject being his own control, in 15 patients with stable obstructive chronic respiratory insufficiency (OCRI), but not infected and with a high PaCO2. The efficiency of the product was judged notable nine times, medium four times; only twice was its action judged inefficient. Retrospectively, it was not possible to define the group OCRI with high PaCO2, responding or not to the oral form of Doxapram. In these conditions, the utility of prescribing this molecule is subjected to the control of gasometric efficiency before and after absorption. The frequent efficiency of the product leads to the consideration of a regular use in some obstructive chronic respiratory insufficiency.

Aged↗