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Biomedical subjects

M Muhsin

Publications and source records attributed to M Muhsin.

9 recordsLinked to original sources
PubMed2000

Genetic diversity of rice tungro spherical virus in tungro-endemic provinces of the Philippines and Indonesia.

The two adjacent genes of coat protein 1 and 2 of rice tungro spherical virus (RTSV) were amplified from total RNA extracts of serologically indistinguishable field isolates from the Philippines and Indonesia, using reverse transcriptase polymerase chain reaction (RT-PCR). Digestion with HindIII and BstYI restriction endonucleases differentiated the amplified DNA products into eight distinct coat protein genotypes. These genotypes were then used as indicators of virus diversity in the field. Inter- and intra-site diversities were determined over three cropping seasons. At each of the sites surveyed, one or two main genotypes prevailed together with other related minor or mixed genotypes that did not replace the main genotype over the sampling time. The cluster of genotypes found at the Philippines sites was significantly different from the one at the Indonesia sites, suggesting geographic isolation for virus populations. Phylogenetic studies based on the nucleotide sequences of 38 selected isolates confirm the spatial distribution of RTSV virus populations but show that gene flow may occur between populations. Under the present conditions, rice varieties do not seem to exert selective pressure on the virus populations. Based on the selective constraints in the coat protein amino acid sequences and the virus genetic composition per site, a negative selection model followed by random-sampling events due to vector transmissions is proposed to explain the inter-site diversity observed.

Animals↗
PubMed1999

International Congress of Chemotherapy--21st meeting. 4-7 July 1999, Birmingham, UK.

Held every two years, the International Congress of Chemotherapy (ICC) represents one of the most important scientific meetings focusing on antimicrobial and anticancer research as well as therapeutics. The chairman of the scientific committee of the congress, Richard Wise (Professor in Clinical Microbiology, Birmingham University, UK) described the meeting as a timely opportunity to review and discuss the challenges and advances in the diagnosis, treatment and prevention of infection. 3300 Delegates from 78 countries were in attendance.

Journal Article↗
PubMed1999

World pharmaceuticals--Financial Times tenth annual conference. 22-23 April 1999, London, UK.

This two-day conference was organized by The Financial Times, in association with PriceWaterhouseCoopers LLP. The general theme of the event was the state of the healthcare industry, past, present and future. The main areas covered included addressing the challenges of the 1990s, anticipating the challenges of the next decade, the changing shape of global marketing, IT in healthcare, consolidation challenges, shareholder expectations, and new strategies and technologies for growth sustenance within the industry. Key speakers within the industry addressed these issues to an audience of approximately 200 healthcare business executives. The first day was chaired by Mr Robert Cawthorn (Chairman Emeritus, Rhone-Poulenc Rorer Inc) and the second by Professor Trevor Jones (Director General, Association of the British Pharmaceutical Industry).

Journal Article↗
PubMed1999

INFOTECHpharma '99--the information revolution in the pharmaceutical industry. 28-29 January 1999, London, UK.

This meeting bought together 180 directors and heads of research spanning all disciplines of the pharmaceutical industry. With the backdrop of increasing globalization, the major theme of the conference was concerned with the necessary improvement of pharmaceutical development processes. The role of new and emerging technologies in the increasing number of new leads generated, and the necessary information and knowledge management that this entails was examined from the perspective of R and D process improvement. Identifying superior clinical candidates using predictive ADME parameters, thereby avoiding costly screening processes, was addressed, while at the post-launch stage of the process the use of IT and www technology and how these can be effectively integrated into the business process to enhance productivity was reviewed.

Journal Article↗
PubMed1999

Sustaining growth and profitability--The Economist fifth annual pharmaceuticals conference. 12-13 November 1998, London, UK.

This two-day conference, organized by The Economist, focused on R and D productivity, strategic and innovative methodologies, M and A activities and knowledge management within the pharmaceutical industry. Key speakers within the industry addressed these issues to an audience of approximately 100 healthcare business executives. The first day was chaired by Barrie Haigh (Quintiles Translational Corp) and the second day by Tobias Rooney (Gemini Consulting).

Journal Article↗