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Biomedical subjects

M Munteanu

Publications and source records attributed to M Munteanu.

At least 19 recordsLinked to original sources
PubMed2006

A prospective assessment of an 'a la carte' regimen of PEG-interferon alpha2b and ribavirin combination in patients with chronic hepatitis C using biochemical markers.

In therapy with standard interferon and ribavirin, five independent risk factors (RF) were predictive of relapse. The aim was to prospectively validate an a la carte regimen of pegylated interferon (PEG-IFN) alpha2b 1.5 microg/kg and ribavirin 11 mg/kg [PEG-IFN-ribavirin (PEG-IFN-R)], taking into account these five risk factors in order to determine whether to continue an additional 24 weeks of treatment in polymerase chain reaction (PCR) negative patients after 24 weeks. Treatment was stopped after 24 weeks in PCR positive patients. The same regimen was continued in PCR negative patients for an additional 24 weeks if patients had two or more RF. FibroTest and ActiTest assessed the impact of treatment on the histological features from baseline to end of follow-up. A total of 96 patients were included; 84 (87.5%) had at least two RF and 12 (12.5%) had no or one RF. A total of 70 patients were sustained virologic response (SVR; 73%), 19 were nonresponders (20%) and seven were relapsers (7%). The SVR in genotypes 2 or 3 was 85% (34/40) vs 64% in other genotypes (36/56; P = 0.02). There was a decrease (P = 0.003) in fibrosis as estimated by FibroTest, from 0.38 +/- 0.03 (mean +/- SE) at baseline to 0.33 +/- 0.03 at the 12-week follow-up, and a decrease in activity as estimated by ActiTest, from 0.49 +/- 0.02 to 0.19 +/- 0.03 (P < 0.0001). Improvement in activity was already significant at 12 weeks, even in virologic nonresponders. This study confirms that an a la carte regimen which takes into account not only genotype but also baseline viral load, fibrosis stage, gender and age, is efficient for the PEG-IFN-R combination. It achieves a 73% SVR and a significant decrease in fibrosis and activity as estimated by biochemical markers.

Alanine Transaminase↗
PubMed2005

[Juvenile macular serous detachment of the retinal pigmented epithelium].

Juvenile macular detachment of the retinal pigmented epithelium is a rare chorioretinal disease, more frequent in young people, with a macular or extramacular localization, single or multiple, and with a good functional prognosis. We present 9 patients (11 eyes), with a mean age 41 years. The disease presented a single localization in 8 cases, a multiple localization in 9 cases, was unilateral in 9 cases, and bilateral in 2 cases. Clinical aspects, pathogeny and functional prognosis are discussed.

Adult↗
PubMed2005

[Congenital retinal folds in different clinical cases].

We present 12 clinical cases of congenital retinal folds with different etiologies: posterior primitive vitreous persistency and hyperplasia (7 cases),retinocytoma (1 case). retinopathy of prematurity (1 case), astrocytoma of the retina (1 case), retinal vasculitis (1 case), Goldmann-Favre syndrome (1 case). Etiopathogenic and nosological aspects are discussed; the congenital retinal folds are interpreted as a symptom in a context of a congenital or acquired vitreo-retinal pathology.

Adolescent↗
PubMed2005

The construction of human body--from model to reality.

The human body building represented a complex research topic for the scientist in the most diverse domains. Although their interests and reasons were different, the goal was always the same: establishing a relation to verify the ratio between the dimensions of the constituent segments It appears that the mystery was solved out in the XIX-th century by Adolf Zeising, a German, who, using the statistic calculus, defined the division of a segment by the gold section. This purely mathematic logic confirms the human body's integration in proportion to the finest segments, thus providing the technical instrument of building a fully harmonious human body. The present study aims to compare the ideal, the calculated perfection to the reality, namely the theoretically obtained values to the average values of an 18-year-old male. It appears that the differences refer especially to the limbs; both the superior ones and the inferior ones being longer comparing to the ideal pattern while the bust is shorter and broader.

Adult↗
PubMed2004

[Combined hamartoma of the retina and retinal pigment epithelium].

We report the case of a 31-year-old man who developed a combined hamartoma of the retina and retinal pigment epithelium in the left eye. The diagnosis was determined based on alterations discovered on fundus examination: hyperplasia of the retinal pigment epithelium cells and tortuosity of the vessels and glial epiretinal membrane. These modifications made it possible to differentiate the hamartoma from choroidal melanoma. The patient underwent photocoagulation therapy. His death due to stroke 4 years after therapy made it possible to analyze the eyeball. Histopathological examination revealed alterations due to retinal photocoagulation as well as alterations particular to the primary tumor: hypertrophy of the retinal pigment epithelium and glial and vascular overgrowth.

Adult↗
PubMed2004

[Persistent hyperplastic primary vitreous associated with retinal folds].

The paper presents the case of a 18 years old male suffering from persistent hyperplastic primary vitreous (PHPV) associated with congenital retinal folds. The clinical features and the pathogenic correlations of the two affections are discussed. Comparing to the PHPV, consequence of a embryogenesis flow appeared in the development of the primary hyaloid-vitreous complex, the congenital retinal folds are considered to be the expression of secondary changes, generated by the background of a varied vitreo-retinal pathology.

Adult↗
PubMed2004

[Acute anterior ischemic optic neuropathy in association with optic nerve drusen].

The authors present a case of 31 years old male, with superficial optic disc drusen, complicated with acute anterior ischemic optic neuropathy. The diagnosis was specified clinically, by fluorescein angiography, and by ultrasonography. The disease, very rare cited in the literature, is characteristic for the young adult and has a good prognosis. The unknown pathogeny gives an important place to the compression of the nervous fibres/ciliary circulation by the optic disc drusen, in a limited space and with a high density of optic fibres.

Acute Disease↗
PubMed2003

[Congenital retinal macro-vessel].

This is to show the case of a 40 year old patient, where a congenital retinal macro-vessel was found, the peculiarities of which are increased calibre, intersection of the macular area, arteriovenous shunts and lack of functional disturbances. The disease is rare and its lesional and functional stability is remarkable.

Adult↗
PubMed2003

[Combined hamartoma of pigment epithelium and retina].

This is the description of the case of a 36 year old male, who developed a combined hamartoma of the pigment epithelium and retina in the left eye. The location of the lesion in the macular zone, as well as the peculiar aspect of disease, raised some issues related to differential diagnosis. Attention was paid to the diseases of the posterior pole of eyeball, which, given their aspect of disease, result of a secondary hyperplastic reaction of the EPR, can embody a type of combined pseudohamartoma: retraction syndrome, retinal angiomatosis, pseudohistoplasmosis and others. A 5 years clinical supervision of the patient didn't show major changes.

Adult↗
PubMed2003

[Conjunctival-palpebral Kaposi's angiosarcoma: report of a case].

We describe the case of a 71-year-old man who developed classic Kaposi's sarcoma with conjunctival-palpebral involvement. The diagnosis was made based on clinical and histopathological findings. The lesions of the palpebral and conjunctival teguments were of a nodular tumorous aspect, their clinical particularities similar to other tegumental involvement. The clinical elements, histopathology, and pathogenesis are debated. The effects of local therapy, consisting of intralesional injections with alpha interferon and cryotherapy, were transient.

Aged↗
PubMed2003

[Central serous chorioretinopathy and serous detachment of the pigmentary epithelium. Pathogeny relations].

A number of 7 cases of association of pigment epithelial serous detachment with central serous chorioretinopathy were described. The dye leakages were located at the periphery of the serous detachment (6 cases) and on its anterior surface (1 case). These are due to RPE breaking, as a result of the tension exerted by the build up of choroidal exudate în the subretinal space. Given the circumstances, central serous chorioretinopathy is an atypical clinical type, subsequent to the alterations of the overlying pigment epithelium. This one is differing from the classic type, because of the wide area of the serous detachment and the peripheral location of the dye leakages.

Adult↗
PubMed2003

[Diffuse retinal epitheliopathy].

This is the case of a 45 year man, with diffuse retinal epitheliopathy. The diagnosis was based on the angiofluorographic triad--diffusion sites; triangular lesions of the EPR, located vertically; serous detachments of the EPR. The therapy consisting of photocoagulation of the diffusion sites and of the harmed areas of the EPR led to a standstill of the clinical evolution, during a one year follow up period.

Fluorescein Angiography↗
PubMed2002

Antibody-targeted chemotherapy of older patients with acute myeloid leukemia in first relapse using Mylotarg (gemtuzumab ozogamicin).

We analyzed the safety and efficacy of Mylotarg (gemtuzumab ozogamicin, an antibody-targeted chemotherapy consisting of a humanized anti-CD33 antibody linked to calicheamicin, a potent antitumor antibiotic) in the treatment of 101 patients > or =60 years of age with acute myeloid leukemia (AML) in untreated first relapse in three open-label trials. Mylotarg is administered as a 2-h intravenous infusion at 9 mg/m(2) for two doses with 14 days between doses. The overall remission rate was 28%, with complete remission (CR) in 13% of patients and complete remission with incomplete platelet recovery (CRp) in 15%. Median survival was 5.4 months for all patients and 14.5 months and 11.8 months for patients achieving CR and CRp, respectively. CD33 antigen is present on normal hematopoietic progenitor cells; thus, an expected high incidence of grade 3 or 4 neutropenia (99%) and thrombocytopenia (99%) was observed. The incidences of grade 3 or 4 elevations of bilirubin and hepatic transaminases were 24% and 15%, respectively. There was a low incidence of grade 3 or 4 mucositis (4%) and infections (27%) and no treatment-related cardiotoxicity, cerebellar toxicity, or alopecia. Mylotarg is an effective treatment for older patients with CD33-positive AML in first relapse and has acceptable toxicity.

Acute Disease↗
PubMed2002

[Unilateral myelinated nerve fibers associated with myopia or amblyopia].

There are described a number of 9 clinical cases with unilateral myelinated nerve fibers, associated with myopia or amblyopia. Four cases developed extended myelinated areas, anisometropia with increased values, accentuated amblyopia and macular changes. Patients underwent treatment for amblyopia through correction with spectacles lenses and the occlusion of the congenerous eye. The obtained functional results differentiated the casemix in two groups: with therapeutic failure, 4 cases, characterized by extended myelination, anisometropia with an average of over -10 diopters and macular changes. with therapeutic success, 5 cases, characterized by reduced myelination, anisometropia with an average of over -4 diopters and normal maculae. It has been found a significantly statistical difference between the two groups as regarding the value of the anisometropia. However, the macular aspect has been an important factor in order the therapeutic effect to succeed. This clinical syndrome is differentiated from the unilateral simple myopia with amblyopia and from the myelinated nerve fibers without myopia or amblyopia.

Amblyopia↗
PubMed2002

[Cutaneous palpebral anthrax].

The interest for anthrax is permanent because of its difficult diagnosis, its severe prognosis, and the possibility of its dissemination during biological war and bioterrorism. Cutaneous anthrax is an infectious disease caused by Bacillus anthracis. Palpebral localizations are rare, raising problems of differential diagnosis. The case of a 21-year-old male with palpebral anthrax is presented. The diagnosis was established by the progression of the palpebral lesions (serohemorrhagic vesicle, black necrotic eschar), extended palpebral edema, and positive epidemiological data. During the onset period, the differential diagnosis was difficult because of uncharacteristic symptoms, negative bacteriological tests (previous antibiotic treatment), and the absence of epidemiological data. Treatment with G penicillin led to the patient's cure.

Adult↗
PubMed2002

[Tilted syndrome].

The study displays a number of 27 cases with tilted syndrome. The cases developed peculiar ophthalmoscopic alterations, compound myopic astigmatism and superotemporal perimetric deficiencies. The perimetric deficiency was located at level of the isopters from the middle periphery and improved, to a certain extent, in perimetry with optical correction. The pathogenetic hypothesis of the syndrome are debated, granting a role to the closing default of the embryonic fissure.

Adolescent↗
PubMed2001

[Myelinated nerve fibers associated with cilioretinal artery occlusion].

Although the myelinated nerve fibers are considered as benign, cases associated with retinal vascular abnormalities (telangiectasis, neovascularization, vascular occlusions) have recently been reported, suggesting a possible pathogenic correlation between these elements. Our observation presents a 44-year-old patient, with a sudden decrease of visual acuity in the right eye, discal and peridiscal myelinated nerve fibers, associated with cilioretinal artery occlusion. The general clinical and laboratory examination, except for a drug stabilized arterial hypertension, did not reveal other local or general embolic factors. One year later, the decrease in visual acuity had remained unchanged and the area of the myelinated nerve fibers had diminished. Based on the association between the myelinated nerve fibers, the cilioretinal artery occlusion, the young age of the patient, and the absence of other local or general embolic factors, we consider there is a possible pathogenic correlation between these elements. The action of the myelinated nerve fibers can be explained by a mechanical compression, with the disruption of the cilioretinal artery route, a structurally vulnerable artery.

Adult↗