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Biomedical subjects

M Mydlík

Publications and source records attributed to M Mydlík.

At least 19 recordsLinked to original sources
PubMed1992

Vitamin B6 requirements in chronic renal failure.

According to our results the long-term daily oral supplementation of 6 mg vitamin B6 was sufficient for prevention of vitamin B6 deficiency in chronic renal failure, regular dialysis treatment and CAPD groups of patients. Haemodialysis and charcoal haemoperfusion have led to non-significant decrease of erythrocyte vitamin B6. A favourable effect was found of daily oral administration of 50 mg pyridoxine on electrophoretic mobility of peripheral blood lymphocytes and cellular immunity.

Adult↗
PubMed1992

[ECG Holter monitoring in patients with chronic renal failure in a long-term dialysis program].

Using the Holter method, the authors monitored for 24-hours 30 patients included in a long-term dialyzation programme during and after haemodialysis. A group of 15 patients who had during examination frequent or complex supraventricular or ventricular ectopia was compared with a group of 15 patients with sporadic ectopia. In the arrhythmic group paroxysmal supraventricular tachycardia was recorded in 33% and paroxysmal atrial fibrillation in 13%, polytopic or repetitive ventricular extrasystoles in 14%, couplets in 20% and volleys of ventricular extrasystoles or non-persisting ventricular tachycardia in 20%. Comparison of clinical laboratory and echocardiographic characteristics revealed in the arrhythmic group significantly higher mean ages of patients, higher levels of ionized serum calcium before haemodialysis, C terminal parathormone, the breadth of the interventricular septum, and the authors observed also a higher incidence of hyperechogenity of cardiac structures. On analysis of repolarization ECG changes significant asymptomatic depressions of the ST segment were found which were transient and dominated during the early posthaemodialyzation period in 11 patients of the whole group (37%).

Adult↗
PubMed1991

[Vitamin B12 and folic acid in chronic kidney failure and after kidney transplantation].

Vitamin B12 in plasma, folic acid in plasma and erythrocytes were examined in 11 patients in the polyuric stage of chronic renal failure without dialyzation treatment, in 38 patients included in a long-term dialyzation programme before and after 3 months' oral administration of folic acid--(2 X 5 mg week)--and in 23 patients after transplantation of the kidneys. In none of the examined groups vitamin B12) and folic acid deficiency in plasma was detected. A reduced folic acid level in erythrocytes, but still in the reference range, was found in patients in the long-term dialyzation programme without supplementation. Supplementation with folic acid increased its concentration in plasma 4.5 times and in red cells 5.5 times. Haemodialysis did not influence the concentration of the examined indicators in plasma and red cells. According to the recorded results it is not necessary to supplement patients in long-term dialyzation programme and after renal transplantation with vitamin B12 and folic acid, if their dietary protein intake is not restricted.

Female↗
PubMed1991

[Hemoperfusion of theophylline. An in vitro study].

The authors made 30 haemoperfusions of theophylline in vitro in a closed system, using capsules Hemasorb 800 C, Hemasorb 800 A-2 and 800 A-4. As perfusion solution they used 4 litres of aqueous solution with an osmolality of 286 mmol/kg. The theophylline concentration in solution was 282.8 +/- 5.2 mumol/l. Individual haemoperfusions lasted 5 hours. After the theophylline solution has passed across Hemasorb A-4 the concentration of the substance could be assessed at all time intervals and during the 180th minute the theophylline concentration could be detected also before entering the haemoperfusion capsule. When using Hemasorb 800 A-2, the adsorption capacity of the haemoperfusion capsule was exhausted already during the 180th minute. The assembled results suggested that the most effective theophylline haemoperfusion in vitro was obtained with Hemasorb 800 A-4 and the least effective one with Hemasorb 800 A-2. The authors recommend to use in acute intoxication with theophylline in humans haemoperfusion via Hemasorb 800 A-4.

Hemoperfusion↗
PubMed1991

Serum vitamin A, retinyl esters and vitamin E in nephrotic syndrome.

Serum vitamin A, retinyl esters and vitamin E were increased in a group of 33 patients with chronic glomerulonephritis and nephrotic syndrome without reduction of mean glomerular filtration rate. Despite hypoproteinaemia and reduced values of serum proteins with a different molecular weight, increased values of vitamin A protein carriers were found. Serum total cholesterol, LDL cholesterol, triglyceride, prebeta und beta lipoproteins were increased, HDL cholesterol was within the reference range. Direct relationships were found between serum retinyl esters and vitamin A, and between serum retinyl esters and prealbumin. Indirect relationships were detected between serum total cholesterol and total proteins, serum total cholesterol and albumin, and serum vitamin E and albumin. The increased values of vitamin A, retinyl esters as well as its protein carriers and of vitamin E were probably a manifestation of enhanced protein and lipid synthesis in the liver as a result of albumin depletion. These results show true A and E hypervitaminosis in patients with nephrotic syndrome.

Blood Proteins↗
PubMed1977

[Vitamin A and lipids in serum during long term dialysis program].

The author stated an increased serum level of A-vitamin and triglycerides in non-dialysed and dialysed patients with chronic renal insufficiency. The beta-carotene-serum level was higher only in the group of the non-dialysed patients. Under influence of the haemodialysis a reduction of the triglycerides in the serum developed. A linear correlation between the beta-carotene and the cholesterol serum level in non-dialysed patients and the vitamin A and the triglyceride serum level in patients in the permanent dialysis programme. Finally follows a discussion of the authors on the metabolic sequels of the A-hypervitaminosis in the uraemic syndrome of patients with chronic renal insufficiency.

Adult↗