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Biomedical subjects

M Myquel

Publications and source records attributed to M Myquel.

11 recordsLinked to original sources

[Hysteria in children].

Hysteria can be found in childhood but as all nevrotic problems during the life period, it is not a fixed entity and cannot presume for the personality to come. Diagnosis is often difficult and is mostly made in pediatric unit in front of conversions symptomatology. The difference between transitory somatizations (frequent during childhood) and conversions is important to make. As part of the diagnosis, finding the underlying personality is necessary. Hysteria is mostly found during the latency period and around puberty period. Awareness is important when the diagnosis is made, to be sure to recognize all the cases and only the real one. Two common situations could be isolated: 1. when a symptom cannot be related to a somatic disorder; 2. when the seduction behavior of a maiden creates counter-attitudes of the medical team and family.

Adolescent

Tryptophanemia and tyrosinemia in adolescents with impulsive behavior.

Tryptophan (TRP) and tyrosine (TYR), respectively the circulating precursors of the central serotonergic (5-HT) and catecholamine systems, were measured in eight adolescents with impulsive behavior regardless of the exact type of disorder. The 6 week study period included weekly blood sampling and clinical evaluation. The ratios of TRP and TYR to large neutral amino acids (LNAA), which indicate the availability for the synthesis of neurotransmitters, were calculated. Comparison of results with eight hospitalized controls of the same age (12.5 to 18 years) revealed lower total TRP levels in four adolescent patients, a lower TRP/LNAA ratio in three adolescents, and a lower free TRP concentration in six adolescents with discretely enhanced albuminemia. A slight increase in TYR and the TYR/LNAA ratio was noted in nearly all of the adolescent patients. Despite the heterogeneity of individual biological results, the impulsive behavior subjects in this study seemed to present abnormalities in neurotransmitter precursors.

Adolescent

[Neurological tolerance of lithium-psychotropic drugs association (author's transl)].

The authors have studied the neurological tolerance from the combination of lithium-psychotropic drugs from 265 associated cures carried out on 132 patients between 1971 and 1978. The risk of neurological inability to assimilate is not greater when haldol is combined with lithium by comparison with other combinations where it is not included. Only the presence of cerebral organicity presents a risk factor. The 117 associated cures were preceded by preliminary treatments during which either the lithium or the psychotropic drugs were used to the same extent during the treatment. This series seems to allow on one hand to demonstrate that the incidence of neurological signs is multiplied by two by the combination, on the other hand to note that the intensity of the neurotoxic effects increases.

Adult

[Clinical significance of the erythro-plasmatic ratio of lithium (author's transl)].

Six hundred erythrocyte-plasma lithium ratios have been gathered from 67 patients presenting affective disorders. Ratios values in relapse period are not altered regarding those in remission phase as between periods with neuroleptic associations and those without. Ratios values are not noticeably modified by personality, sex and the evolution of affective disorders. But lithium preventive action is essentially found in patients with high erythrocyte-plasma.

Antipsychotic Agents

[Two-dimensional immuno-electrophoresis of cephalospinal fluid proteins wih a study of the IgG/albumin ratio in psychiatry (author's transl)].

The purpose of this study (about 187 adult psychiatric patients) is to investigate correlations between "organic brain syndrome" (vascular or abiotrophic) and values of CSF proteins (technique of two-dimensional immunoelectrophoresis). The authors show positive correlations between 'vascular' brain syndrome and increase of one alpha 2 globulin, between 'abiotrophic' brain syndrome and decrease in all globulins, the importance of brain damage and increase of IgG/albumin ratio.

Adult