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Biomedical subjects

M N Kuznetsova

Publications and source records attributed to M N Kuznetsova.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Some biological mechanisms of the inborn predisposition to alcoholism.

The children of alcoholism patients have a high biological risk of this illness, mental and emotional disorders, and behavioral disturbances. The offspring of white mongrel rats with chronic alcohol intoxication were investigated in order to study the neurochemical mechanisms of these phenomena. The content of DA in blood and blood plasma, the characteristics of GABA and the opiate receptors of the brain, the activity of DBH, COMT, MAO, the content of cAMP and cGMP in brain tissue, as well as the expression of the gene c-fos were studied. Changes in the brain content of DA and qualitative and quantitative changes in MAO (an increase and solubilization of MAO A and B activity in the liver) were identified in the offspring of alcoholic rats. A tendency was also observed in the brain toward a decrease in the activity of DBH and COMT and an increase in the activity of cAMP and cGMP. The baseline expression of the gene c-fos in the offspring of male alcoholic rats did not differ from the norm; however, a powerful increase in the expression of the gene c-fos did appear in response to the administration of 2 g/kg of ethanol, in the absence of this effect in the control. A view is presented on the significant role of changes in the functions of the DA system in the genesis of pathology in the offspring of parents with chronic alcohol intoxication, as well as on the possible influence of the prolonged consumption of alcohol on the function of the genome.

Alcoholism↗
PubMedDate not supplied

[The survival of mice and the metallothionein content of their livers and kidneys as criteria for assessing exposure to pulsed neutron radiation].

The effect of pulsed neutron radiation was studied in comparison with continuous neutron radiation and continuous gamma-radiation. Animal survival and induction of metallothionein (MT) synthesis in liver and kidney of mice exposed to equivalent doses were chosen as criteria for evaluation of radiation effects. It was found that the level of MT in liver and kidney of mice exposed to neutron radiation decreased 24 hours after irradiation and then continued decreasing in kidney for 48 hours after irradiation. This is evidence of more intensive free-radical processes initiated by pulsed neutron radiation. At the same time, RBE values of pulsed neutrons did not differ significantly from that of continuous neutron radiation.

Animals↗
PubMedDate not supplied

[Effect of active immunization with dopamine- and norepinephrine-protein conjugated on neurochemical and neurophysiologic parameters of withdrawal syndrome in chronically morphine-treated rats].

The impact of induction of antibodies to the catecholamines (CA) dopamine (DA) and norepinephrine (NE) during active immunization of rats with CA conjugated to protein (BSA) on morphine dependence, withdrawal syndrome, and neurotransmitter status was studied during 14-day morphine treatment. DA-BSA and NE-BSA immunization of rats provided lower plasma DA concentrations in naloxone-precipitated opiate withdrawal. However, it failed to lead to normalization of hypothalamic DA levels and exacerbated the withdrawal syndrome. In immunized rats, including those immunized with BSA, the hypothalamic levels of DA and epinephrine (E) were even higher than in morphine-treated rats previously unimmunized. The aggravation of withdrawal symptoms was especially pronounced in rats preimmunized with NE-BSA, which could be due to a significant NE rise in the brain tissue.

Animals↗