Biomedical subjects

M N Stolyarov

Publications and source records attributed to M N Stolyarov.

2 recordsLinked to original sources

PubMed2003

Coherence resonance and polymodality in inhibitory coupled excitable oscillators.

We have analyzed the firing activity of two and three excitable FitzHugh-Nagumo oscillators, coupled via slow variable diffusion and under the action of an external noise. We find a different form of coherence resonance in this system, which is, in contrast to previous studies, intrinsically based on the antiphase behavior of coupled elements. Additionally, we show that an exchange, performed by this form of coupling, is remarkably rhythmogenic and results in polymodal interspike distributions without any external periodic stimuli. The dependence of these distributions on the noise amplitude and the coupling strength is studied.

Journal Article↗

PubMed1994

Temporal variability in a system of coupled mitotic timers.

Cell proliferation is considered a periodic process governed by a relaxation timer. The collective behavior of a system composed of three identical relaxation oscillators in numerically studied under the condition that diffusion of the slow mode dominates. We demonstrate: (1) the existence of three periodic regimes with different periods and phase relations and an unsymmetrical, stable steady-state (USSS); (2) the coexistence of in-phase oscillations and USSS; (3) the coexistence of periodic attractors; and (4) the emergence of a two-loop limit cycle coexisting with both in-phase oscillations and a stable steady-state. The qualitative reasons for such a diversity and its possible role in the generation of cell cycle variability are discussed.

Biological Clocks↗