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Biomedical subjects

M Nambu

Publications and source records attributed to M Nambu.

71 records · Page 4Linked to original sources
PubMed1981

Nine cases with marked retention of indocyanine green test and normal sulfobromophthalein test without abnormal liver histology: constitutional indocyanine green excretory defect.

Nine patients revealed marked retention in the indocyanine green (ICG) test and the normal sulfobromophthalein (BSP) test. The results of liver function tests in these cases were within normal limits with the exception of the ICG test. The ICG plasma disappearance rate ranged from 0.017 to 0.025, whereas that of BSP ranged from 0.058 to 0.126. The transfer rate of ICG from plasma to liver markedly decreased on two-compartmental analysis of the ICG decay curve. A transient delay of the ICG plasma disappearance (step formation) on the decay curve was observed over 20 to 25 minutes after an injection in all cases after repeated observation. Binding of ICG to plasma proteins in these cases failed to demonstrate a significant difference from normal subjects. The fasting serum bile acid levels in two cases and postprandial serum bile acid level in one case were normal. Light microscopic findings of the liver revealed normal histology. Electron microscopic findings showed increase of lipofuscin-like lysosomes, modification and paracrystalline-like array of mitochondria, and an increase of reticulum fiber in Disse's space. It is suggested that these cases represent a new type of dye excretory disorder of the liver with impaired hepatic uptake of ICG.

Adenocarcinoma↗
PubMed1977

Sulfobromophthalein and indocyanine green binding by the hepatic cytoplasmic proteins.

The elution patterns of human and rat liver supernate mixed with BSP or ICG have been demonstrated using G-100 Sephadex gel filtration. The elution pattern in the rat liver remained the same as that shown by Levi et al. In the human liver BSP localized to Y protein could hardly be demonstrated, whereas ICG was detected. This pattern was quite similar in Rotor's hyperbilirubinemia and in Crigler-Najjar syndrome Type II. These observations suggest that the impaired hepatic transportation of organic anions in congenital hyperbilirubinemias may not be related to cytoplasmic organic anion-binding proteins.

Animals↗
PubMed1976

Consideration of hepatic factor influence on drip infusion cholangiography.

The plasma disappearance rate (K) and transfer rate constants for the two compartmental system of Indocyanine Green (ICG) were calculated in visualized and nonvisualized cases of the biliary tract with hepatobiliary disease using drip infusion cholangiography (DIC). In nonvisualized cases with hepatocellular disorder K and the fractional hepatic removal rate mainly decreased, and in nonvisualized cases with cholelithiasis the fractional biliary secretory rate significantly decreased by DIC-A, utilizing it as a screening test. Three methods (B,C and D) of drip infusion cholangiography were established according to the result of the I-CG test. Through DIC-B, C- or -D in addition to DIC-A the visualization of the biliary tract significantly elevated in patients with hepatocellular disorder and cholelithiasis. These results were confirmed using 131I-iodipamide. In some cases the serum transaminase activity elevated, but the elevation was temporary.

Biliary Tract Diseases↗
PubMed1975

The constitutional indocyanine green excretory defect--report of four cases.

Four cases revealed high retention of ICG test and normal retention of BSP test were reported. The results of liver function test of these cases showed within normal limit except ICG retention. ICG disappearance rate ranged from 0.017 to 0.025, whereas BSP disappearance rate ranged from 0.069 to 0.126. The transfer rate of ICG from plasma to liver markedly decreased by two compartmental analysis of the decay curve and slightly reduced transfer rate of BSP from plasma to liver was also observed. The step on both ICG and BSP disappearance curve was observed during 20 to 25 minutes after the injection in all cases and in repeated observations. The step formation is one of the characteristic changes in these cases. The ICG binding capacity of serum protein decreased in the first peak and increased in the third peak eluted by gel filtration of Sephadex G-200. Light microscopic findings of the liver showed normal histology. The electronmicroscopic findings showed the increase of lipofuscin-like lysosome, modification and paracrystalline like array of mitochondria and increase of reticulum fiber in Disse's space. Father of a case showed ICG retention without BSP retention. From these results it is suggested that these cases are a new type of dye excretory disorder of liver with heredity or constitution.

Adult↗
PubMedDate not supplied

Detection of liver membrane antibodies in patients with non-insulin-dependent diabetes mellitus.

Circulating liver membrane antibodies (LMAb) were examined in 71 patients with non-insulin-dependent diabetes mellitus (NIDDM) without liver dysfunction and 16 cases of KK mouse as a model of obese diabetic animals. LMAb were detected in 10 NIDDM patients (14.1%). Fasting blood glucose, glycosylated serum albumin (G-Alb), and glycosylated hemoglobin A1 (HbA1) levels were compared with LMAb-positive and negative groups. The G-Alb levels and HbA1 levels of the LMAb-positive group were significantly higher (p less than 0.05 and p less than 0.01, respectively) than those of the LMAb-negative group. In addition, there were no differences in histological findings in KK mouse liver between the LMAb-positive and negative cases. These results revealed that the state of continued high blood glucose directly or indirectly influence the autoimmunity and clinical features of NIDDM patients.

Animals↗
PubMedDate not supplied

Treatment of patients with chronic hepatitis using ursodeoxycholic acid.

We treated 82 patients of chronic hepatitis using 300 mg. of ursodeoxycholic acid (UDCA) daily and observed them for a mean of 10 mo before and 16 mo after UDCA administration. Seven liver function tests (AST, ALT, ALP, LAP, GTP, Ch-E and T-cholest) were assessed monthly. The values were compared before and after the administration of UDCA. The AST, ALT, LAP and GTP improved significantly in the UDCA treated patients, whereas ALP, Ch-E and T-cholest. did not show any change throughout the study. Amongst the liver function tests that improved, the serum--GTP level, in particular decreased markedly and rapidly in patients treated with UDCA. Although UDCA 600-mg daily was administered in patients who showed lack of improvement with 300-mg UDCA treatment, no significant improvement was obtained. Repeated liver biopsies were carried out in six of the 42 patients in whom liver biopsy had been performed before the administration of UDCA. We detected no histological changes during the UDCA treatment. There were no side effects related to therapy with UDCA. In conclusion, we confirmed that UDCA is a safe and effective drug for treating patients with chronic hepatitis and may help in prevention of progression of the disease, particularly in patients with a high serum--GTP level.

Adult↗