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Biomedical subjects

M Navarrete

Publications and source records attributed to M Navarrete.

42 records · Page 3Linked to original sources
PubMedDate not supplied

[Cytogenetics and cytochemistry of leukemia patients in 2 neotropical hospitals].

A cytogenetic and/or cytochemical study was performed in 166 individuals with leukemia or related disorders, in two major Costa Rican hospitals. In those patients treated at an adult's hospital (14 years old and over), acute leukemias represented 66% of all cases. In that hospital the most frequent types of disorders were, in decreasing order: ANLL (> M1), ALL, CML (all of them showed the Ph chromosome) and MDS. In the cases from a childrens' hospital (< 14 years old) acute leukemias were 98%. Among them the order of frequency was: ALL (70%): ALL-1 (84%), ALL-2 (16%) and ANLL (27%): M5a > M3 > M4 > M5b. In ALL 85% were type B and occurred mostly in women while 15% of them were type T and more frequent in males. There was 5.6% infant leukemia, which presented a similar number of acute lymphoids and myeloids. The cytogenetic pattern was similar among Costa Rica and other tropical and temperate countries.

Adolescent↗
PubMedDate not supplied

[Meaning of pleocytosis in spinal fluid in children with neoplasias].

Thirty-five spinal fluids with leucocytosis belonging to 26 children presenting neoplasia without metastases or CNS infection, were studied. We found that 69% of the cases were receiving some kind of CNS therapy, although leucocytosis could be found at any moment of the evolution and independently of treatment. It is stressed that the criteria for meningeal infiltration in children with neoplasia must be established only if tumoral cells are found in the spinal fluid. Pleocytosis and absence of symptomatology must not be used as the main criteria.

Cerebrospinal Fluid↗
PubMedDate not supplied

[Hematologic features of nutritional anemias in children].

In eighty nine anemic children, aged from 6 months to 13 years, the etiology of their anemia was studied: 67(75%) of the cases presented iron deficiency, 18(20%) iron and folate deficiency and 4 megaloblastic anemia (2 folate and 2 vitamin B12 deficiency). Patients with vitamin B12 deficiency showed severe pancytopenia and megaloblastic changes in bone marrow; but no morphological difference, either in circulating blood or bone marrow was found in patients with iron deficiency, compared to iron plus folate deficiency. The seric measurement of iron, folate and B12 were essential in order to establish the etiology of nutritional anemias. The majority of the children were accepted to the hospital for other causes than anemia, such as diarrhea (58%) and respiratory diseases (18%). Clinical features and the high incidence of anemia in children under two years of age are also discussed.

Adolescent↗
PubMedDate not supplied

[Disseminated histoplasmosis in children].

Clinical features and treatment evaluation of 38 children with disseminated histoplasmosis were studied. Thirty-six cases presented the severe form and two of them showed the mild chronic type. A higher incidence of this disease was found in infants (65%) and in severe malnutrition (68%) and lethality in the overall group was 61%. Patients died either because they did not receive specific treatment or were given amphotericin for less than 15 days. These figures stress the importance of this treatment in disseminated histoplasmosis.

Amphotericin B↗