PubMed Health⌕ Search

Biomedical subjects

M Naylor

Publications and source records attributed to M Naylor.

33 records · Page 2Linked to original sources
PubMed1992

Best of the best.

Explore the source record for details and available documents.

Community Health Nursing↗
PubMed1992

Mood disorder in a group of self-cutting adolescents.

This study describes the occurrence of mood disorder in a group of adolescent inpatients involved in self-cutting behavior. Although self-cutting is generally said to be associated with borderline personality disorder, a substantial number of patients who cut themselves in our study were clinically depressed. In addition, the self-cutting adolescents had a high prevalence of child abuse, past psychiatric history, and family psychiatric history. The incidents tended to spread by contagion and occur at times of change affecting the milieu. Clinical implications of these findings are discussed.

Adolescent↗
PubMed1991

Chronic depression and hospital course in adolescents.

Survival curves were used to analyze the relationship between chronicity of depression and hospital course in 48 adolescents with unipolar major depression. The 25 adolescents with chronic depression (defined as a continuous course of depressive illness for 1 year or more) did not differ from those with acute depression in age, gender, or socioeconomic status. Despite similar admission and discharge Children's Depression Rating Scale-Revised scores, adolescents with chronic depression had a significantly slower initial rate of improvement. The study suggests that chronicity of depression has predictive validity with regard to acute hospital course in adolescents.

Adolescent↗
PubMed1985

The antiviral activity of tetrazole phosphonic acids and their analogues.

5-(Phosphonomethyl)-1H-tetrazole and a number of related tetrazoles have been prepared and their effects on the replication of Herpes Simplex Viruses-1 and -2 have been investigated as well as their abilities to inhibit the DNA polymerases induced by these viruses and the RNA transcriptase activity of influenza virus A. Contrary to an earlier report, 5-(phosphonomethyl)-1H-tetrazole was not an efficient inhibitor of the replication of HSV-1 and HSV-2 in tissue culture. Analogues of 5-(phosphonomethyl)-1H-tetrazole were also devoid of significant antiviral activity. Only 5-(phosphonomethyl)-1H-tetrazole and 5-(thiophosphonomethyl)-1H-tetrazole inhibited the influenza virus transcriptase, and both were more effective as inhibitors than phosphonoacetic acid under the same conditions. The DNA polymerases induced by HSV-1 and HSV-2 were inhibited slightly by 5-(phosphonomethyl)-1H-tetrazole and to a lesser extent by its N-ethyl analogue and 3-(phosphonomethyl)-1H-1,2,4-triazole. None of these compounds were as effective as phosphonoacetic acid. 5-(Thiophosphonomethyl)-1H-tetrazole was a better inhibitor of the DNA polymerase induced by HSV-1 than 5-(phosphonomethyl)-1H-tetrazole.

Antiviral Agents↗
PubMed1985

Thio-analogues of inorganic pyrophosphate inhibit the replication of influenza virus A in vitro.

Mono- and bisthiopyrophosphate can inhibit the replication of influenza virus A/X49 in Madin-Darby canine kidney (MDCK) cells at concentrations at which no cytotoxic effect is observed after 3 days. The thiopyrophosphate analogues inhibit the RNA transcriptase activity of this virus possibly by chelating with an essential metal ion in the transcriptase complex. [31P]NMR spectroscopy indicates that bisthiopyrophosphate coordinates to zinc through sulphur and magnesium through oxygen which may influence the inhibitory properties of this compound with metal-containing enzymes.

Antiviral Agents↗
PubMedDate not supplied

Preventing pressure ulcers through use of protocols in a mentored nursing model.

Few conditions offer a better opportunity for nurses to have a dramatic and visible impact on quality care than skin care. Nursing interventions targeted to prevent pressure ulcers and their painful, costly complications are an expected standard of care in all care settings. Preventing pressure ulcers may be most important in the acute care setting, where previously healthy elders with acute illness, immobility, impaired appetite, and new-onset incontinence may suddenly and unexpectedly develop pressure ulcers. Often acute care nurses have not been fully cognizant of the threat that pressure ulcers can pose for acutely ill patients. Teaching nurses skills of prevention, including assessments, and interventions for this group of patients is critical. Traditional teaching methods supplemented with an innovative mentoring program and clinical protocols may be one way to accomplish this.

Clinical Protocols↗
PubMedDate not supplied

Home is best.

Explore the source record for details and available documents.

Female↗