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Biomedical subjects

M Nechifor

Publications and source records attributed to M Nechifor.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[The semisynthetic production of pharmacologically active flavone derivatives. I. The pharmaco-toxicological properties of theophylline-rutozide (TR 1722)].

The pharmaco-toxicological properties of the compound theophylline-rutozide, termed conventionally TR-1722, are presented. Studied comparatively with aminophylline, it presents important advantages: soluble in water, the aqueous solutions have a pH close to the physiological one and are stable. It induces a weaker excitation on the central nervous system as compared to aminophylline, but its antihistaminic and anti-inflammatory properties are slightly increased. The physicochemical and pharmacological properties of TR 1722 recommend it for the patients with asthma and associated arterial hypertension or obstructive bronchopneumopathy associated with pulmonary hypertension.

Aminophylline↗
PubMedDate not supplied

Researches on the influence of some pharmacological interferences of the metabolism of icosanoids on the glycemia in rats.

We studied the influence of cloprostenol (CIPG) 200 micrograms/Kg i.p. (a synthetic analogue of PGF2-alpha) and of imidazol 70 mg/Kg i.p. (a selective inhibitor of thromboxane synthetase) on fasting glycemia and on hypoglycemia induced by Actrapid insulin 0.5 UI/Kg i.p. to rats (male adults). The determinations of glycemia were made 60 minutes and 3 hours after the administration of the substances. The tests were made in groups of 20 animals which were not fed 14 hours before the experiment, but were not deprived of water. The results were interpreted statistically by means of the "t" test. The data obtained show that CIPG 200 micrograms/Kg i.p. is a significant hyperglycemic icosanoid (statistically p less than 0.01) both in the case of fasting glycemia and in the case of insulin hypoglycemia. The hyperglycemic effect was stronger at 60 min. Imidazol does not modify significantly either glycemia or insulin hypoglycemia, which pleads for a more reduced implication of thromboxanes in the regulation of glycemia in comparison to the prostaglandins.

Animals↗
PubMedDate not supplied

Neuroendocrine involvements of the prostaglandin autacoids.

The eicosanoids are a system of lipid autacoids that are considered to play a role in the modulation of central nervous system (CNS) functions. This modulating effect seems to have three components: a) modulation of neuronal function and especially involvements in biological signal transduction at the level of the neuronal membrane: b) modulation of neurotransmitter release at synaptic level; c) modulation of the response amplitude of some CNS centers and areas to various stimuli, with implications in animal and human behaviour. Personal data show that cyclooxygenase inhibitors lower the seizure threshold and amplify the tonic aspect of the electric shock-induced seizure, while imidazole (thromboxane synthetase inhibitor) has no influence on the duration of seizures and seizure-free intervals, but makes the seizures have a clonic rather than tonic aspect.

Animals↗
PubMedDate not supplied

[The action of a fibric acid derivative on lipid metabolism].

The action of N-2 (p-chlorophenoxy isobutiril)-N-morpholino-methylureea on some serum lipids parameters in rats with normolipemia and tritonic hyperlipidemia was studied. In the animals with normolipidemia, the compound induces hypocholesterolemia beginning with the 5th day of treatment, hypotriglyceridemia during the entire investigation interval and an increase of phospholipid levels in the 9th day of treatment. In the rats with tritonic hyperlipidemia, the substance induces hypocholesterolemia, hypotriglyceridemia, increase of HDL-cholesterol levels, decrease of (VLDL + LDL)--cholesterol levels and the return to normal values of Glueck ratio.

Animals↗