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M Nehéz

Publications and source records attributed to M Nehéz.

36 records · Page 2Linked to original sources
PubMed1983

Effect of dimethoate and O-demethyldimethoate on bone marrow cells of CFLP mice.

The organophosphorus pesticide dimethoate and its nonalkylating O-demethyl derivative were tested for their ability to induce chromosomal alterations in bone marrow cells of CFLP mice after ip administration. A single dose of 20 mg/kg dimethoate proved to be ineffective. However, doses of 60 mg/kg dimethoate or 69 mg/kg O-demethyldimethoate sodium salt significantly increased the aberration rates above those of the controls. The same effect was observed after a nontoxic dose of 690 mg/kg O-demethyldimethoate sodium salt. Considering the distribution of the several aberration types, these findings suggest that the alkylating properties of dimethoate only in part may be responsible for its cytogenetic activity.

Alkylation↗
PubMed1982

The effects of five weeks treatment with dinitro-o-cresol- or trifluralin-containing pesticides on the germ cells of male mice.

The effects of two pesticides, the insecticide-herbicide Krezonit E, which contains 50% dinitro-o-cresol, and the herbicide Olitref, which contains 26% trifluralin (2,6-dinitro-N,N-dipropyl-4-trifluoromethylaniline), on the gonads and germ cells of male mice were studied. The pesticides were given twice a week for 5 weeks in i.p. doses of 0.6 mg kg-1 for Krezonit E and 6.0 mg kg-1 for Olitref. These doses are 1% of the i.p. LD50. Cytogenic analysis of germ cells carried out from 3 weeks onwards after the last treatment day showed that Olitref significantly increased the frequency of germinal chromosomal abnormalities at 6-7 weeks after treatment. This pesticide increased the frequency of autosomal univalents X/Y separations at meiotic metaphase and multivalent configurations. Krezonit E did not increase significantly the number of chromosomal abnormalities, although there was some increase at 3 weeks, mainly in the form of autosomal univalents.

Animals↗
PubMedDate not supplied

Experience of health status surveillance of pesticide workers in Hungary.

The authors studied potential dermal exposure in 26 men and also conducted epidemiological studies in three southeastern agricultural counties in Hungary covering 189 men working with pesticides in plant protection indoors and in the fields, and in 16 women in contact with these compounds. There were no acute intoxications, nor were there any alterations in routine clinical and laboratory tests. For early detection of hidden damage the authors used examination of the chromosomes: the rate of numerical chromosome aberrations was increased due to increase of hypodiploid cells in the exposed. The probability of chromosome damage was also demonstrated by the tests conducted in the few women tested. In previous studies on the immune functions in some of the men tested the immunological tests proved to be positive. Though changes might be induced also by other factors, the authors believe it is important to frequently screen the exposed population in the manner described.

Adult↗