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Biomedical subjects

M Nehmzow

Publications and source records attributed to M Nehmzow.

8 recordsLinked to original sources
PubMed1990

[Dopamine antagonists in anovulation?].

Increased hypothalamic dopamine turnover may prevent the ovulatory LH peak by different mechanisms and may in this way result in anovulation. Ten patients with anovulatory menstrual cycles who had been treated with clomiphene citrate without success were given the dopaminolytic drug pimozide (Antalon) at a dose of 5 mg/day orally either from day 7 to day 11 (7 women; group 1) or from day 11 to day 15 of the menstrual cycle (4 women; group 2). One patient from group 2 ovulated during the treatment cycle. A further woman from this group exhibited an LH peak, but did not ovulate, whereas a slow increase of the circulating LH level was recorded in the remaining two patients. Systematic investigations should clarify whether introduction of dopaminolytic therapy in the treatment of hypothalamic anovulation may be justified.

Anovulation↗
PubMed1990

[Ovulation induction using clomiphene conversion].

20 anovulatory and clomiphene resistant patients had been treated by the so called clomiphene conversion. Pregnancies could be achieved in 6 women. 7 further patients reacted by ovulation. In selected cases the clomiphene conversion may be an alternative of therapy with gonadotrophins and GnRH pulsatile.

Adolescent↗
PubMed1988

[Initial experiences in the use of pulsatile Gn-RH administration for ovulation induction].

In 9 patients the pulsatile administration of Gn-RH for the induction of ovulation was given in 13 treatments, we used the minipump Zyklomat of the firm Ferring and a Gn-RH pump from ZID Karlsburg. The administration was carried out for 10 to 18 days with dosages from 2.5 to 20 micrograms Gn-RH per pulse. 9 patients did ovulate and 5 patients became pregnant.

Adult↗
PubMed1988

[Release of estrogen-induced positive feedback in the follicular phase].

Influence of estradiol on the secretion of pituitary gonadotropins in a sense of positive feedback in formating not until the progress of development of puberty. Appearance of positive feedback mechanism, which cause the secretion of LH and FSH reason of increasing estrogen doses, induces menstrual cycle. In 10 healthy, normally menstruating women plasma LH and FSH have been measured before and every 12 hours after an intramuscular injection of 50 micrograms estradiol benzoate per kg body weight. A positive feedback could be observed between the 5th and 14th day of the menstrual cycle. At first the LH-concentration decreased and then after 36-48 hours estradiol benzoate injection induced an increase of LH.

Adult↗
PubMed1987

[Detection of the early pregnancy factor (EPF) in the serum of patients with questionable pregnancy].

The early pregnancy factor (EPF) has been detected in sera of 24 women with a doubtful pregnancy by means of the rosette inhibition test using a horse antihuman lymphocyte serum. In all sera of women with an intact early pregnancy the EPF was found, furthermore in a pregnancy ending as abortion and two cases of an Arias Stella phenomenon. In non-pregnant patients the EPF was not detectable with exception of two patients under medication and one patient suffering from dysmenorrhea membranacea.

Chaperonin 10↗
PubMed1985

[Bromocriptine therapy of prolactinoma in pregnancy].

A report is given about the course of pregnancy and delivery of two patients with prolactin-producing pituitary adenomas and therapy with bromocriptine. Different views about treatment of prolactinomas in pregnancy are discussed. Pregnancy care has to be in close cooperation between endocrinologists and obstetricians.

Adenoma↗