PubMed Health⌕ Search

Biomedical subjects

M Neilson

Publications and source records attributed to M Neilson.

11 recordsLinked to original sources
PubMed1990

Diagnosis, personality and the long-term outcome of depression.

Patients diagnosed in the late 1960s as suffering from either endogenous or neurotic depression, or as presenting with depression but discharged with another neurotic diagnosis, were followed for 15 years. Diagnosis at index admission did not predict overall outcome, but patients with endogenous depression, an apparently stable diagnosis, had longer index admissions, were readmitted sooner, but spent less time ill than patients in either of the neurosis groups. Personality abnormality accounted for 20% of the variance in outcome in the neurotic groups and only 2% of the variance in the endogenous group. Thus there is evidence that endogenous and neurotic depression are two illnesses and that, in the neuroses particularly, prognosis will depend on the extent to which these personality abnormalities are modified by treatment.

Depressive Disorder↗
PubMed1988

Stuttering.

Explore the source record for details and available documents.

Adolescent↗
PubMed1988

The long-term outcome of depressive illness.

One hundred and forty-five patients with primary depressive illness admitted to a university hospital between 1966 and 1970 were followed up an average of 15 years later. Adequate data were obtained on 133 (92%) of the 145. During the follow-up period, 7% of the 133 had suicided, 12% had remained incapacitated by illness and only 20% had remained continuously well. Patients for whom the index admission was not their first were especially likely to be readmitted during the follow-up period. Patients with endogenous depression, none of whom developed schizophrenia during the follow-up period, were more likely to need readmission than patients with an index diagnosis of neurotic depression. In all other respects the prognosis for the two types of depression was the same, with considerable morbidity evident in both.

Adult↗
PubMed1987

Complement depletion suppresses Lewis rat experimental allergic neuritis.

Lewis rats immunized with myelin and complete Freund's adjuvant were treated with cobra venom factor (CVF) which depletes the C3 component of complement. CVF given at day 9 delayed the onset of experimental allergic neuritis (EAN) by 2-3 days and when given at days 9 and 12 delayed the onset of EAN by 4-5 days. Lumbar nerve roots of CVF-treated rats had significantly less demyelination than those from control EAN rats.

Animals↗
PubMed1977

Depressive illness: the role of aggression further considered.

Measures of depression and undischarged drive were obtained for 292 psychiatric in-patients. In 200 of these cases inhibition of aggression was also assessed. All patients were classified as being endogenously depressed, reactively depressed, or as suffering from non-depressive primary disorders. The latter group was subdivided into secondarily depressed and non-depressed groups. The 3 depressed groups were then compared with the non-depressed subjects in respect of drive level and inhibition of aggressionmall 3 depressed groups showed significantly higher driver level than did the non-depressed subjects. The endogenous depressives also inhibited significantly more of their aggression than did the non-depressed subjects. The results are consistent with a drive inhibition theory of depression. However, while endogenous depression seems to be associated more specifically with the inhibition of aggression, reactive depression may be associated rather with the inhibition of drive generally.

Adjustment Disorders↗
PubMed1976

Mental disorder and season of birth--a southern hemisphere study.

Studies on the relationship between season of birth and mental disorder have been substantially confined to northern hemisphere regions. Such studies have generally found an excess of winter births of schizophrenics, and variably an excess of winter births of manic-depressive and mentally retarded patients. In the present study information on sex, diagnosis and date of birth was obtained on all 20,358 patients first admitted to psychiatric facilities in New South Wales between July 1970 and June 1974 and born in New South Wales. The collective 1962-71 monthly live-births for New South Wales were used as a control. A significant winter excess was found for the female schizophrenic group, while a significant spring excess was found for neurotic patients, most marked in those with anxiety neurosis. It is hypothesized that the relationship between schizophrenia and winter birth is consequent upon a greater sensitivity of schizophrenics to those physiological factors which determine conception in the general population.

Adjustment Disorders↗
PubMedDate not supplied

[Estimation of severity of illness in intensive care: validation of physiologic stability index].

Physiological stability index (PSI) is a score proposed to evaluate the severity of different diseases in pediatric intensive care units (PICU) by giving scores to the deterioration of 34 measurable physiological variables. In order to validate PSI, it was prospectively applied to 132 patients who entered our PICU. A significant difference (p less than 0.001) was found between the average score of those patients who survived (means: 6.1) versus those who did not (means: 21); No difference was found between theoretical mortality rates obtained by logistic regression analysis and those obtained according to PSI score ranks even thought direct hemodynamic measurements like cardiac output and capillary (wedge) pulmonary pressure were not considered in this study. In conclusion, the PSI is a useful method to measure the severity of illness in pediatric intensive care and to compare results among PICU.

Adolescent↗