Biomedical subjects
M Neves-e-Castro
Publications and source records attributed to M Neves-e-Castro.
The HERS trial.
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[Should all menopausal women have hormone replacement therapy for the prevention of coronary disease?].
A review of the biochemical changes which occur after menopause. Menopause is the onset of a chronic hypoestrogenism. The lack of estrogens which follows either a premature oophorectomy or menopause is a cause of risk factors and diseases at several levels, amongst which, due to its importance, is the cardiovascular system. Estrogens can favorably modify those risk factors and thus contribute to a sharp decrease in cardiovascular morbidity and mortality. For this reason, its use is legitimate for the primary and secondary prevention of coronary disease.
Oral contraceptives and breast cancer.
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[Androgens and sterility].
The hyperandrogenisms, and in particular those which accompany polycystic ovaries, should always be treated, because the risk of carcinoma of the endometrium and of the breast is increased in these cases. Sterility is inconstant, but can benefit from treatment.
Response of plasma estradiol-17beta to synthetic FSH-LH/RH: a preliminary study.
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Unilateral streaked ovary syndrome. Slotnick-Goldfarbs syndrome.
A case of unilateral streaked ovary (Slotnick-Goldfarb's syndrome) is reported and documented with hormonal, chromosomal, laparoscopic, and histologic studied. It is postulated that viral oophoritis associated with mumps might explain the coexistence of a streaked ovary of a congenital origin with a hypoplastic ovary, tbat would be the expression of a factor acting in postnatal life.
The possible role of high estriol levels in pregnancy.
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The pathogenesis of endomeerial carcinoma.
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The effect of synthetic FSH-LH/RH on plasma FSH, LH and 17beta-estradiol in women under oral steroid contraception.
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