[Current treatment of headaches].
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Biomedical subjects
Publications and source records attributed to M Nieto Barrera.
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OBJECTIVE: The association of a language disorder with epilepsy is observed in some circumstance, with or without a causal relationship. In Landau-Kleffner syndrome (LKS), it is estimated that the aphasia is directly caused by epileptic discharges in language areas. PATIENTS AND METHODS: Ten children with LKS are studied. The clinical and electroencephalographic characteristics in these ten cases were analyzed. RESULTS: Aphasia was present between 3 years and 6 years 5 months of age (X: 4 years 8 months) in a progressive form in 8 cases and abruptly in 2 cases. The epileptic seizures present in nine children began between 22 months and 7 years 3 months of age (X: 4 years 1 month). Focal, multifocal and/or generalized discharges, unstable and variable, were frequently noted during awake state EEG records and on EEGs during the sleep state in four children continuous spike waves during 75-80% of slow sleep were observed. CONCLUSIONS: We discuss the importance of the different clinical and EEG findings in the evolution of aphasia which condition the longterm prognosis, emphasizing the value of the discharges on the sleep EEGs. This suggests that LKS could be the severe form of a more widespread age-dependent epileptic syndrome that also includes the CSWS (epilepsy with continuous spike and waves during slow sleep) and the atypical benign partial epilepsy. Three syndromes have cognitive and behavioral manifestations and continuous spike waves during slow sleep.
Difficult-control epilepsy (DCE) is diagnosed when response to drug therapy is slight and/or the patient's quality of life is affected. Careful evaluation is important so that DCE is not diagnosed when persistent seizures are due to diagnostic or treatment errors. DCEs are a heterogenous group of epilepsies and epileptic syndromes that have risk factors in common as well as those that are specific to each type. Childhood DCE is more frequently in the first three to four years of life. DCE presents as a secondary generalized epilepsy, multifocal epilepsy and partial epilepsy, in order of decreasing frequency. Some DCEs are cryptogenic. Others--most--are symptoms of a variety of causal agents, some of which are acquired or, less often, progressive. They are commonly associated to neurological signs and/or psychiatric impairment. New drugs have effected a noteworthy decrease in seizures in some of the most severe epileptic syndromes of childhood. Other therapeutic options, such as treatment with hormones or immunoglobulins or vagal stimulation, can sometimes prove useful. Finally, surgical treatment must be considered in some DCE cases, particularly in partial epilepsy.
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A group of 23 children aged 5 months to 6 years a diagnosis of Guillain Barré syndrome has been analysed. In 2/3 of our patients the illness appeared in autumn-winter period. We considered muscle weaknesses, pain and impairments of cranial nerves to be the main characteristics of the disease. The presence of denervation activity was an indication of worse evolutive prognosis. Hormone treatment was started in 21 cases and plasma exchange in one more, with rapid reduction of the vegetative and the motor symptoms. The progress was considered to be highly favourable in all of them. One child had a recidivant form of this disease.
Hypomelanosis of Ito (incontinentia pigmenti achromians) is a neurocutaneous syndrome consisting of bizarre, patterned, macular hypopigmentation over variable portions of the body surface. Associated defects in other systems occur, commonly in the central nervous system, in a significant percentage of affected individuals. Six children affected by hypomelanosis of Ito are presented. Similarities and differences between hypomelanosis and incontinentia pigmenti and systematized achromic nevus are discussed.
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The brain abscess is not frequent in childhood. However, they have important and serious consequences. We have studied the natural history of fifteen cases, emphasizing the situations in which they appear with the purpose to avoid them. Our results are similar to those of other series in regard to the etiology, manifestations, diagnosis and treatment. The incidence was greater in males (66.6%) and between 10 to 15 years of age (53.3%). ENT infections and meningoencephalitis were the main origin in the same proportion (33.3%), followed by cyanotic congenital heart diseases (13.3%). Mortality rate was 20% and two survivors (13.3%) showed very important motor sequel. One of them (6.6%), also had a partial epilepsy. Our results recall the need for a better knowledge of pathogenesis and treatment of these patients.
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64 children with seizures occuring during sleep were studied. No claim is made to definitive clinical results, but the clinical peculiarities of certain epileptic crises that tend to occur more frequently in sleep are presented. In 62.5% of all our cases are being treated as benign epilepsy, with centro-temporal E.E.G. foci and typical characteristics of age, hour of appearance and therapeutic response. In 32.5% are generalized seizures, and these have the widest age range at onset. The fits are at times unrelated to the length of previous sleep and respond less favourably to treatment. In 5% are either unilateral seizures or partial complex one. The incidence of a positive family history is higher than found in other epileptic groups, suggesting that sleep seizures are genetically determined.