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M Nieto

Publications and source records attributed to M Nieto.

94 records · Page 6Linked to original sources
PubMedDate not supplied

[Semiquantitative evaluation of cranial computerized tomography as diagnostic support in progressive supranuclear palsy].

INTRODUCTION AND OBJECTIVES: Different neuroimaging findings have been described in association with progressive supranuclear palsy (PSP), but their use as diagnostic support in this condition has been the subject of much discussion. PATIENTS AND METHODS: Three radiologists, non-specialists in neuroradiology and with no specific information regarding neuroimaging in Parkinson syndromes, analyzed (without knowing any clinical details) seven cranial CT in five patients diagnosed as probable PSP according to NINDS-SPSS criteria, nine with idiopathic Parkinson's disease, and six persons aged over 55 years who acted as controls. The radiologists were asked to assess 17 variables as absent, moderate or severe. The results were analyzed using the chi squared test for qualitative variables and Fisher's exact test when necessary. RESULTS: The identification of the variables antero-posterior and transversal atrophy of the mid-brain, atrophy of the pons, enlargement of the perimesencephalic cisterns and the quadrigeminal plate and increased size of the third ventricle were considered to be statistically significant in the cases of PSP as compared with other observations. The small number of patients did not permit the establishment of correlation of statistical importance between the radiological parameters and clinical condition. CONCLUSIONS: We present the point of view of non-specialist neuroimaging workers, in these patients. We found that there were six parameters of interest on cranial CT which permitted differentiation of cases of PSP, idiopathic Parkinson's disease and a control population. Four of these parameters did not appear to a severe degree in patients who did not have PSP. These results are partly comparable to those published in the literature.

Aged↗
PubMedDate not supplied

[Contribution to studies of seizures in Rett's syndrome. Analysis of critical forms of four cases].

Twenty girls were diagnosed as having Rett's Syndrome (RS) based on criteria decided upon in 1988. Fifteen suffered epileptic fits, four of which were possible to record by EEG. In this work we report on the clinical EEG semiology of these girls. All underwent clinical, biochemical, electroneurophysical, neuroimaging and cytogenetic studies. Periodic EEG were carried out while the girls were awake and the recorded fits were so obtained. All had night-time EEG. Four girls had their first fits between 5 years 4 months and 6 years 5 months (average 6 years). The ages at which their attacks were recorded varied from seven to eleven years. Two girls presented tonic-axial attacks expressed graphically by desynchronisation in the EEG in one case and rhythmically in the other, one having had atypical simple absences expressed on EEG as point-wave complexes at a rate of two per second, the other presenting two types of attack: initially tonic-axial fits expressed as a low amplitude rhythm and a year later generalised clonal fits expressed as slow waves with sharp waves in between. Outstanding is the fact that despite the diversity of epileptic fits described in RS all such attacks recorded were of a generalised type.

Anticonvulsants↗
PubMedDate not supplied

[Single photon emission tomography (SPECT) in severe infantile myoclonic epilepsy (EMS)].

Ten children, three boys and seven girls, with an average age of 7.5 years diagnosed as having severe myoclonic epilepsy (SME) underwent single photon emission computerised tomography (SPECT) with HMPAO. All had CT, nuclear MR and various EEG studies, these findings made at the same time as SPECT. CT and nuclear MR produced no relevant data. EEG, although without paroxystic abnormalities in two cases, showed generalised discharge in the remaining eight, predominantly in the right hemisphere in five. SPECT was normal in two cases (of 20 and 30 months) and showed areas of hypoperfusion localised in one hemisphere in five cases, three in the left and two in the right, and in both hemispheres in three cases. Areas of hypoperfusion were located in frontal and/or temporal and/or parietal regions. In two cases there was concordance with the prevalence of EEG paroxystic activity and in two other cases there was discordance. Our findings, with SPECT abnormalities after two years of age, suggest SME could be considered as a multifocal epilepsy brought on by secondary structural irregularities.

Adolescent↗