PubMed Health⌕ Search

Biomedical subjects

M Nikolov

Publications and source records attributed to M Nikolov.

9 recordsLinked to original sources
PubMed1990

[Hyperfiltration in diabetic patients].

Glomerular filtration and effective renal plasma flow were studied in 24 patients with diabetes mellitus type I (mean age 29.8 +/- 10.5 years) and 20 patients with diabetes mellitus type II (mean age 54 +/- 11 years) and duration of diabetes 5.7 +/- 6 and 11.3 +/- 10 years respectively. There were no clinical signs of nephropathy in all patients studied (the albustick test was negative). The results were compared with those of 30 healthy controls. Out of the 24 patients with diabetes mellitus type I 10 (41%) were with hyperfiltration and from the 20 patients with diabetes mellitus type II only one was with hyperfiltration. The speed of albumin secretion in the diabetic patients with hyperfiltration was 39.9 +/- 42.9 micrograms/min and was significantly higher than that of the diabetic patients without hyperfiltration--26.2 +/- 22.7 micrograms/min. The albuminuria was in a moderate positive correlation with the glomerular filtration. The possible mechanism taking part in the development of hyperfiltration syndrome in diabetes are discussed.

Adult↗
PubMed1989

[The correlation of glycohemoglobin (HbA1) with the parameters of blood glucose control during the treatment of diabetes mellitus].

40 diabetic patients (18 patients with diabetes mellitus type I and 22 patients with diabetes mellitus type II) were examined for an average period of 6 months (from 0.5 up to 24 months). The following glycemic parameters were determined: glycohemoglobin (HbA1), average glucose of 6 glucose profiles, fasting glucose, the average of two postprandial glucose concentrations and the M-value. Correlation coefficients between the HbA1 and the parameters studied were determined. In the course of suitable treatment all patients' data were significantly improved. High correlation coefficients were found between HbA1 and the average of the two postprandial glucose concentrations and between HbA1 and the M-value (r = 0.61 and r = 0.60 respectively). The average profile glucose, the average of two postprandial glucose concentrations and the M-value show as reliable parameters for a long-term control compared with the most reliable index HbA1.

Adult↗
PubMed1989

Captopril in treatment of hypertensive diabetic patients. Preliminary study.

This investigation was performed in 15 adult patients: 6 with type I and 9 with type II diabetes mellitus, all with arterial hypertension. Captopril (12.5 to 100 mg daily, mean 34 mg) was administered for a month and was effective as monotherapy in all patients. The supine arterial pressure changed from: 177 +/- 19 mm Hg to 141.7 +/- 7.7 mm Hg systolic and 106 +/- 7.6 mm Hg to 87.3 +/- 5.3 mm Hg diastolic; and upright: from 162.7 +/- 16 mm Hg to 139 +/- 11.4 mm Hg systolic and from 101.7 +/- 11.6 mm Hg to 87.3 +/- 6.5 mm Hg diastolic. The differences were statistically significant (p less than 0.001). The mean blood glucose was changed significantly at the end of the study (from 11.1 +/- 3.4 mmol.l-1 to 8.1 +/- 1.0 mumol.l-1, p less than 0.001), while the daily insulin dose (respectively glybenclamide) remained unchanged. No alterations in serum creatinine, HbA1 (glycohemoglobin), urinary excretion rate of albumin, beta 2-microglobulin, glomerular filtration rate were observed during follow-up. No important change in plasma aldosterone was found, while plasma renin activity was significantly increased (p less than 0.05) as expected. No side effects were reported during the therapy. Captopril appears to be an effective and safe drug for lowering blood pressure in diabetic patients without affecting renal function.

Captopril↗
PubMed1988

[The level of glycosylated hemoglobin in obese patients].

The glycosylated hemoglobin level was examined in 37 obese patients without manifested diabetes mellitus. The level was in the reference ranges. The patients who had lowered carbohydrate tolerance showed a tendency toward a higher glycohemoglobin level. The reduction of body mass was accompanied by a decrease of glycohemoglobin.

Adolescent↗
PubMed1978

[Effect of triquinol on the central nervous system].

The authors examined the influence of the preparation triquinol on the function of the central nervous system, using neuropharmacological and electrophysiological methods. Traquinol in small doses revealed slight stimulating central effect, causing uneasiness, increased reaction to touch and pain, slight exophthalmia, These manifestations were accepted as a sign of the sympathycomimetic action of the preparation. The large doses caused myorelaxing phenomena-reduced spontaneous motor activity, muscular tonus, inhibition of the polysynaptic reflexes. Electroencephalographic examinations showed lowering of the threshold for obtaining the reaction of waking during acute experiments and of the threshold for obtaining desynchronization after exteroceptive stimuli. These data could be explained by the sympathycomimetic effect of the preparation.

Animals↗