Biomedical subjects

M Noa

Publications and source records attributed to M Noa.

42 records · Page 3Linked to original sources

PubMed1980

Hyperpolarisation of rat peritoneal macrophages phagocytosing latex particles.

The changes that take place in the plasma membrane during endocytosis are still poorly understood. Studies of the electrical properties and related permeabilities of cells during pinocytosis and phagocytosis should provide insight into these changes. This approach has not been much exploited, although there have been a few relevant reports. For example, induction of pinocytosis in amoebae produces a marked decrease in plasma membrane resistance, and exposure of polymorphonuclear leukocytes to phagocytosable particles can engender alterations in ionic permeabilities. The present report demonstrates that the induction of phagocytosis in rat peritoneal macrophages is accompanied by a sustained hyperpolarisation of the cells.

Animals↗

PubMedDate not supplied

One-year dog toxicity study of D-002, a mixture of aliphatic alcohols.

D-002 is a mixture of high-molecular-weight aliphatic alcohols, obtained from bees wax (Apis mellifera), with mild anti-inflammatory properties and effective anti-ulcer activities demonstrated in experimental models. This study investigated the oral toxicity of D-002 administered for 1 year to beagle dogs. Twenty-four beagle dogs (12 males and 12 females) were distributed randomly in three experimental groups (four animals per group): a control and two treated groups received D-002 at 50 and 250 mg kg(-1) (7 days/week) by gastric gavage. Overall, D-002 was well tolerated throughout the study. No signs or symptoms of toxicity were observed, and no mortality occurred during the study. All groups showed similar weight gain and food consumption. No hematological, blood biochemical or histopathological disturbances attributable to treatment were observed. This study shows no drug-related toxicity induced by long-term administration of up to 250 mg kg(-1) D-002 to beagle dogs.

Administration, Oral↗

PubMedDate not supplied

Induction of aortic plaques in guinea pigs by exposure to kerosene.

Guinea pigs were exposed to kerosene aerosols or to smoke produced from kerosene under conditions approximating those in a kitchen. They were compared to controls exposed to saline aerosols or to atmospheric air. Both types of kerosene exposure engendered aortic plaques with fibrous tissue, collagen, and elastic fibers embedded in abundant glycosaminoglycans-rich ground substance, interspersed in which are smooth muscle cells resembling those seen in atherosclerosis, and changes in levels of blood lipids. The results suggest that chronic exposure to kerosene, a domestic fuel very widely used in many countries, may have important toxic effects in addition to the pulmonary effects that have been reported by others.

Administration, Inhalation↗

PubMedDate not supplied

Cytologic and biochemical changes in pulmonary washings of guinea pigs exposed to kerosene.

Guinea pigs were exposed to kerosene aerosol and compared to controls exposed to atmospheric air. Kerosene exposure induced cytologic and biochemical changes in the pulmonary washings of guinea pigs. Our results suggest that in chronic exposure to kerosene lung washings can be used as a rapid screening tool to detect the inflammatory response in the lungs.

Aerosols↗

PubMedDate not supplied

Effects of kerosene on airway sensitization to egg albumin in guinea pig.

We undertook a study to determine if pre-exposure to kerosene smoke enhances airway sensitization to egg albumin in the guinea pig. Kerosene vapor inhalation for 15 days, 1 hour daily, in similar conditions to which some housewives who use kerosene as cooking fuel are exposed elicited tracheal damage characterized by signs of dysplasia and inflammatory infiltrate. When these animals were exposed to egg albumin aerosol there was an increase in the antialbumin antibody blood titer and an increased response to egg albumin in the isolated tracheal preparation (Schultz-Dale reaction), We conclude that the airway damage elicited by inhalation of kerosene vapor increase antigen absorption and thereby antibody formation.

Aerosols↗

PubMedDate not supplied

[Morphological changes in the respiratory tract of guinea pigs exposed to kerosene aerosol].

It's well known that there exists a high correlation between daily usage of Kerosene and the appearance of dyspnea in healthy humans and in asthmatic patients. Our aim is to study the histological alterations of the respiratory tract of guinea pigs submitted to Kerosene aerosol. It was administered to male guinea pigs fifteen minutes daily for a month. Fragments of trachea and lungs were processed for histological studies. Erosion of tracheal epithelium and inflammatory infiltration were observed. Lungs presented with thickening of the interalveolar septa. The eosinophilic infiltration may represent an immunological response resembling reactions of immediate hypersensitivity. The morphological alterations may be induced by toxic products of Kerosene such as sulphur impurities that act as mucosal irritants which damage defense mechanisms of the organism.

Aerosols↗